SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A7Y_A_DVAA8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.74A	1a7yA-2z5lA: undetectable	1a7yA-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A7Y_B_DVAB2_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.83A	1a7yB-2z5lA: undetectable	1a7yB-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A7Y_B_DVAB8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.79A	1a7yB-2z5lA: undetectable	1a7yB-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FDS_A_ESTA350_1 (17-BETA-HYDROXYSTERO ID-DEHYDROGENASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	SER A 370 VAL A 371 TYR A 383 GLY A 410 SER A 425	None	1.16A	1fdsA-2z5lA: 9.7	1fdsA-2z5lA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HPV_B_478B200_1 (HIV-1 PROTEASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 9	LEU A 124 GLY A 160 VAL A 212 GLY A 205 ILE A 163	None	0.95A	1hpvA-2z5lA: undetectable	1hpvA-2z5lA: 11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I3W_E_DVAE2_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.73A	1i3wE-2z5lA: undetectable	1i3wE-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I3W_E_DVAE8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.83A	1i3wE-2z5lA: undetectable	1i3wE-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I3W_F_DVAF8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.73A	1i3wF-2z5lA: undetectable	1i3wF-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I3W_G_DVAG2_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.77A	1i3wG-2z5lA: undetectable	1i3wG-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I3W_G_DVAG8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.78A	1i3wG-2z5lA: undetectable	1i3wG-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1I3W_H_DVAH8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.80A	1i3wH-2z5lA: undetectable	1i3wH-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MNV_D_DVAD2_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.80A	1mnvD-2z5lA: undetectable	1mnvD-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MNV_D_DVAD8_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.75A	1mnvD-2z5lA: undetectable	1mnvD-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OVF_B_DVAB2_0 (ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.80A	1ovfB-2z5lA: undetectable	1ovfB-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QFI_A_DVAA8_0 (ACTINOMYCIN X2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.75A	1qfiA-2z5lA: undetectable	1qfiA-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QFI_B_DVAB8_0 (ACTINOMYCIN X2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.84A	1qfiB-2z5lA: undetectable	1qfiB-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T9W_A_NFNA6001_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	SER A 234 GLY A 445 ARG A 257	None	0.66A	1t9wA-2z5lA: 1.7	1t9wA-2z5lA: 18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_F_DVAF2_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.80A	1unjF-2z5lA: undetectable	1unjF-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_F_DVAF8_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.72A	1unjF-2z5lA: undetectable	1unjF-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_L_DVAL2_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.85A	1unjL-2z5lA: undetectable	1unjL-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_L_DVAL8_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.83A	1unjL-2z5lA: undetectable	1unjL-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_R_DVAR2_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.86A	1unjR-2z5lA: undetectable	1unjR-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_R_DVAR8_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.78A	1unjR-2z5lA: undetectable	1unjR-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_X_DVAX2_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.83A	1unjX-2z5lA: undetectable	1unjX-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNJ_X_DVAX8_0 (7-AMINO-ACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.82A	1unjX-2z5lA: undetectable	1unjX-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNM_E_DVAE8_0 (7-AMINOACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.84A	1unmE-2z5lA: undetectable	1unmE-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNM_F_DVAF2_0 (7-AMINOACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 37 PRO A 35 THR A 36	None	0.79A	1unmF-2z5lA: undetectable	1unmF-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UNM_F_DVAF8_0 (7-AMINOACTINOMYCIN D)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	THR A 36 THR A 37 PRO A 35	None	0.75A	1unmF-2z5lA: undetectable	1unmF-2z5lA: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_D_BEZD2385_0 (CES1 PROTEIN)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 5	LEU A 107 LEU A 59 LEU A 31 LEU A 74	None	1.08A	1yajD-2z5lA: 3.4	1yajD-2z5lA: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJG_A_ADNA1501_1 (235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA- CARBOXYLASE] LIGASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 7	ARG A 256 GLU A 261 PRO A 237 ALA A 263	None	1.35A	2ejgA-2z5lA: undetectable	2ejgA-2z5lA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_A_SAMA1001_0 (SAM DEPENDENT METHYLTRANSFERASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	ALA A 230 ALA A 228 ALA A 232 GLY A 448 GLY A 445	None	1.06A	2igtA-2z5lA: 2.4	2igtA-2z5lA: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IGT_B_SAMB1002_0 (SAM DEPENDENT METHYLTRANSFERASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	ALA A 230 ALA A 228 ALA A 232 GLY A 448 GLY A 445	None	1.05A	2igtB-2z5lA: 5.2	2igtB-2z5lA: 24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KOT_A_ANWA99_0 (PROTEIN S100-A13)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 7	VAL A 318 PHE A 365 THR A 405 ARG A 398	None	1.11A	2kotA-2z5lA: undetectable	2kotA-2z5lA: 10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 6	TYR A 383 ALA A 384 ALA A 408 THR A 455	None	0.89A	3b6hB-2z5lA: undetectable	3b6hB-2z5lA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_A_CHDA151_0 (ILEAL BILE ACID-BINDING PROTEIN)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 7	ILE A 243 GLY A 248 VAL A 440 LEU A 286	None	0.92A	3elzA-2z5lA: undetectable	3elzA-2z5lA: 12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GYQ_A_SAMA270_0 (RRNA (ADENOSINE-2'-O-)-ME THYLTRANSFERASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	LEU A 162 ALA A 213 GLY A 141 ILE A 163 LEU A 165	None	1.32A	3gyqA-2z5lA: 2.5 3gyqB-2z5lA: undetectable	3gyqA-2z5lA: 21.38 3gyqB-2z5lA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GYQ_B_SAMB270_0 (RRNA (ADENOSINE-2'-O-)-ME THYLTRANSFERASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 11	LEU A 162 ALA A 213 GLY A 141 ILE A 163 LEU A 165	None	1.23A	3gyqB-2z5lA: undetectable	3gyqB-2z5lA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HS6_B_EPAB1_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	GLY A 251 ILE A 243 ALA A 297 SER A 270 GLY A 245	None	1.02A	3hs6B-2z5lA: undetectable	3hs6B-2z5lA: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NY4_A_SMXA310_1 (BETA-LACTAMASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 8	LEU A 426 ALA A 465 THR A 468 GLY A 373	None	0.83A	3ny4A-2z5lA: undetectable	3ny4A-2z5lA: 21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UBO_B_ADNB353_2 (ADENOSINE KINASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 5	SER A 370 ILE A 250 TYR A 383 GLY A 410	None	1.04A	3uboB-2z5lA: 5.0	3uboB-2z5lA: 24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UR0_C_SVRC516_1 (RNA-DEPENDENT RNA POLYMERASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 9	PRO A 62 GLY A 64 ALA A 65 ALA A 68 LEU A 73	None	1.35A	3ur0C-2z5lA: undetectable	3ur0C-2z5lA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VLN_A_ASCA904_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 6	PHE A 338 ARG A 102 LEU A 333 PRO A 335	None	1.39A	3vlnA-2z5lA: undetectable	3vlnA-2z5lA: 18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTZ_A_H4BA600_1 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 6	VAL A 457 ARG A 429 TRP A 461 PHE A 464	None	1.46A	4ctzA-2z5lA: 0.8 4ctzB-2z5lA: 0.0	4ctzA-2z5lA: 21.56 4ctzB-2z5lA: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D7B_A_TCWA1126_1 (TRANSTHYRETIN)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 6	LEU A 443 ALA A 446 LEU A 444 SER A 234	None	1.21A	4d7bB-2z5lA: undetectable	4d7bB-2z5lA: 15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DMG_B_SAMB401_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA1493)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 11	TYR A 220 GLU A 197 ALA A 199 ASP A 164 PRO A 166	None	1.31A	4dmgB-2z5lA: 6.6	4dmgB-2z5lA: 24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 8	ASP A 326 ASN A 377 GLU A 154 GLU A 423	None	1.03A	4feuD-2z5lA: undetectable	4feuD-2z5lA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEV_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 7	ASP A 326 ASN A 377 GLU A 154 GLU A 423	None	1.10A	4fevB-2z5lA: undetectable	4fevB-2z5lA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 7	ASP A 326 ASN A 377 GLU A 154 GLU A 423	None	1.08A	4fewB-2z5lA: undetectable	4fewB-2z5lA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 8	ASP A 326 ASN A 377 GLU A 154 GLU A 423	None	1.06A	4gkhD-2z5lA: undetectable	4gkhD-2z5lA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAR_A_ERMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	ALA A 442 TRP A 412 PHE A 368 LEU A 352 THR A 321	None	1.50A	4iarA-2z5lA: undetectable	4iarA-2z5lA: 22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IB4_A_ERMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	VAL A 300 ALA A 357 PHE A 365 LEU A 390 VAL A 318	None	1.25A	4ib4A-2z5lA: undetectable	4ib4A-2z5lA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NC3_A_ERMA1202_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	VAL A 300 ALA A 357 PHE A 365 LEU A 390 VAL A 318	None	1.23A	4nc3A-2z5lA: undetectable	4nc3A-2z5lA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_A_IBPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 10	VAL A 456 ARG A 7 GLY A 231 ALA A 230 SER A 1	None	1.01A	4ph9A-2z5lA: undetectable	4ph9A-2z5lA: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_B_IBPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 10	VAL A 456 ARG A 7 GLY A 231 ALA A 230 SER A 1	None	1.01A	4ph9B-2z5lA: undetectable	4ph9B-2z5lA: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UG5_A_H4BA902_1 (NITRIC OXIDE SYNTHASE OXYGENASE)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	ARG A 429 THR A 374 TRP A 375	None	1.27A	4ug5A-2z5lA: undetectable	4ug5A-2z5lA: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECL_A_ILEA602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 6	ALA A 140 THR A 98 VAL A 101 VAL A 346	None	1.01A	5eclA-2z5lA: 0.4	5eclA-2z5lA: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KXI_A_NCTA402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 8	TYR A 8 THR A 479 TRP A 375 LEU A 476	None	1.39A	5kxiA-2z5lA: undetectable 5kxiB-2z5lA: undetectable	5kxiA-2z5lA: 21.02 5kxiB-2z5lA: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KXI_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 8	TYR A 8 THR A 479 TRP A 375 LEU A 476	None	1.41A	5kxiD-2z5lA: undetectable 5kxiE-2z5lA: undetectable	5kxiD-2z5lA: 21.02 5kxiE-2z5lA: 21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L4I_B_6J3B201_0 (TRANSTHYRETIN)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 6	LEU A 443 ALA A 446 LEU A 444 SER A 234	None	1.21A	5l4iB-2z5lA: undetectable	5l4iB-2z5lA: 14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJE_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	LEU A 266 LEU A 286 ALA A 259 LEU A 443 ARG A 256	None	1.02A	5ljeA-2z5lA: undetectable	5ljeA-2z5lA: 13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7F_A_SAMA301_0 (PUTATIVE O-METHYLTRANSFERASE RV1220C)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	5 / 12	GLY A 376 GLY A 148 GLY A 146 ILE A 105 ALA A 151	None	1.01A	5x7fA-2z5lA: 8.1	5x7fA-2z5lA: 25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	3 / 3	ARG A 9 ARG A 398 ARG A 449	None	1.06A	6bplA-2z5lA: undetectable 6bplB-2z5lA: undetectable	6bplA-2z5lA: 9.35 6bplB-2z5lA: 9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CNJ_D_NCTD402_1 (NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4 NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2)	2z5l	TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2 (Streptomyces fradiae)	4 / 8	TYR A 8 THR A 479 TRP A 375 LEU A 476	None	1.40A	6cnjD-2z5lA: undetectable 6cnjE-2z5lA: undetectable	6cnjD-2z5lA: 9.56 6cnjE-2z5lA: 10.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A7Y_A_DVAA8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.74A","1a7yA-2z5lA:undetectable","1a7yA-2z5lA:6.76"],["1A7Y_B_DVAB2_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.83A","1a7yB-2z5lA:undetectable","1a7yB-2z5lA:6.76"],["1A7Y_B_DVAB8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.79A","1a7yB-2z5lA:undetectable","1a7yB-2z5lA:6.76"],["1FDS_A_ESTA350_1","17-BETA-HYDROXYSTEROID-DEHYDROGENASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"SER A 370;VAL A 371;TYR A 383;GLY A 410;SER A 425","None","1.16A","1fdsA-2z5lA:9.7","1fdsA-2z5lA:23.62"],["1HPV_B_478B200_1","HIV-1 PROTEASE;HIV-1 PROTEASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"LEU A 124;GLY A 160;VAL A 212;GLY A 205;ILE A 163","None","0.95A","1hpvA-2z5lA:undetectable","1hpvA-2z5lA:11.70"],["1I3W_E_DVAE2_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.73A","1i3wE-2z5lA:undetectable","1i3wE-2z5lA:6.76"],["1I3W_E_DVAE8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.83A","1i3wE-2z5lA:undetectable","1i3wE-2z5lA:6.76"],["1I3W_F_DVAF8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.73A","1i3wF-2z5lA:undetectable","1i3wF-2z5lA:6.76"],["1I3W_G_DVAG2_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.77A","1i3wG-2z5lA:undetectable","1i3wG-2z5lA:6.76"],["1I3W_G_DVAG8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.78A","1i3wG-2z5lA:undetectable","1i3wG-2z5lA:6.76"],["1I3W_H_DVAH8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.80A","1i3wH-2z5lA:undetectable","1i3wH-2z5lA:6.76"],["1MNV_D_DVAD2_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.80A","1mnvD-2z5lA:undetectable","1mnvD-2z5lA:6.76"],["1MNV_D_DVAD8_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.75A","1mnvD-2z5lA:undetectable","1mnvD-2z5lA:6.76"],["1OVF_B_DVAB2_0","ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.80A","1ovfB-2z5lA:undetectable","1ovfB-2z5lA:6.76"],["1QFI_A_DVAA8_0","ACTINOMYCIN X2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.75A","1qfiA-2z5lA:undetectable","1qfiA-2z5lA:6.76"],["1QFI_B_DVAB8_0","ACTINOMYCIN X2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.84A","1qfiB-2z5lA:undetectable","1qfiB-2z5lA:6.76"],["1T9W_A_NFNA6001_1","ACRIFLAVINE RESISTANCE PROTEIN B","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"SER A 234;GLY A 445;ARG A 257","None","0.66A","1t9wA-2z5lA:1.7","1t9wA-2z5lA:18.96"],["1UNJ_F_DVAF2_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.80A","1unjF-2z5lA:undetectable","1unjF-2z5lA:6.76"],["1UNJ_F_DVAF8_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.72A","1unjF-2z5lA:undetectable","1unjF-2z5lA:6.76"],["1UNJ_L_DVAL2_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.85A","1unjL-2z5lA:undetectable","1unjL-2z5lA:6.76"],["1UNJ_L_DVAL8_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.83A","1unjL-2z5lA:undetectable","1unjL-2z5lA:6.76"],["1UNJ_R_DVAR2_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.86A","1unjR-2z5lA:undetectable","1unjR-2z5lA:6.76"],["1UNJ_R_DVAR8_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.78A","1unjR-2z5lA:undetectable","1unjR-2z5lA:6.76"],["1UNJ_X_DVAX2_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.83A","1unjX-2z5lA:undetectable","1unjX-2z5lA:6.76"],["1UNJ_X_DVAX8_0","7-AMINO-ACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.82A","1unjX-2z5lA:undetectable","1unjX-2z5lA:6.76"],["1UNM_E_DVAE8_0","7-AMINOACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.84A","1unmE-2z5lA:undetectable","1unmE-2z5lA:6.76"],["1UNM_F_DVAF2_0","7-AMINOACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  37;PRO A  35;THR A  36","None","0.79A","1unmF-2z5lA:undetectable","1unmF-2z5lA:6.76"],["1UNM_F_DVAF8_0","7-AMINOACTINOMYCIN D","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"THR A  36;THR A  37;PRO A  35","None","0.75A","1unmF-2z5lA:undetectable","1unmF-2z5lA:6.76"],["1YAJ_D_BEZD2385_0","CES1 PROTEIN","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"LEU A 107;LEU A  59;LEU A  31;LEU A  74","None","1.08A","1yajD-2z5lA:3.4","1yajD-2z5lA:20.98"],["2EJG_A_ADNA1501_1","235AA LONG HYPOTHETICAL BIOTIN--[ACETYL-COA-CARBOXYLASE] LIGASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ARG A 256;GLU A 261;PRO A 237;ALA A 263","None","1.35A","2ejgA-2z5lA:undetectable","2ejgA-2z5lA:18.60"],["2IGT_A_SAMA1001_0","SAM DEPENDENT METHYLTRANSFERASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"ALA A 230;ALA A 228;ALA A 232;GLY A 448;GLY A 445","None","1.06A","2igtA-2z5lA:2.4","2igtA-2z5lA:24.32"],["2IGT_B_SAMB1002_0","SAM DEPENDENT METHYLTRANSFERASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"ALA A 230;ALA A 228;ALA A 232;GLY A 448;GLY A 445","None","1.05A","2igtB-2z5lA:5.2","2igtB-2z5lA:24.32"],["2KOT_A_ANWA99_0","PROTEIN S100-A13","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"VAL A 318;PHE A 365;THR A 405;ARG A 398","None","1.11A","2kotA-2z5lA:undetectable","2kotA-2z5lA:10.37"],["3B6H_B_MXDB551_1","PROSTACYCLIN SYNTHASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"TYR A 383;ALA A 384;ALA A 408;THR A 455","None","0.89A","3b6hB-2z5lA:undetectable","3b6hB-2z5lA:21.15"],["3ELZ_A_CHDA151_0","ILEAL BILE ACID-BINDING PROTEIN","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ILE A 243;GLY A 248;VAL A 440;LEU A 286","None","0.92A","3elzA-2z5lA:undetectable","3elzA-2z5lA:12.08"],["3GYQ_A_SAMA270_0","RRNA (ADENOSINE-2'-O-)-METHYLTRANSFERASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"LEU A 162;ALA A 213;GLY A 141;ILE A 163;LEU A 165","None","1.32A","3gyqA-2z5lA:2.5;3gyqB-2z5lA:undetectable","3gyqA-2z5lA:21.38;3gyqB-2z5lA:21.38"],["3GYQ_B_SAMB270_0","RRNA (ADENOSINE-2'-O-)-METHYLTRANSFERASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"LEU A 162;ALA A 213;GLY A 141;ILE A 163;LEU A 165","None","1.23A","3gyqB-2z5lA:undetectable","3gyqB-2z5lA:21.38"],["3HS6_B_EPAB1_1","PROSTAGLANDIN G\/H SYNTHASE 2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"GLY A 251;ILE A 243;ALA A 297;SER A 270;GLY A 245","None","1.02A","3hs6B-2z5lA:undetectable","3hs6B-2z5lA:22.01"],["3NY4_A_SMXA310_1","BETA-LACTAMASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"LEU A 426;ALA A 465;THR A 468;GLY A 373","None","0.83A","3ny4A-2z5lA:undetectable","3ny4A-2z5lA:21.86"],["3UBO_B_ADNB353_2","ADENOSINE KINASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"SER A 370;ILE A 250;TYR A 383;GLY A 410","None","1.04A","3uboB-2z5lA:5.0","3uboB-2z5lA:24.71"],["3UR0_C_SVRC516_1","RNA-DEPENDENT RNA POLYMERASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"PRO A  62;GLY A  64;ALA A  65;ALA A  68;LEU A  73","None","1.35A","3ur0C-2z5lA:undetectable","3ur0C-2z5lA:22.32"],["3VLN_A_ASCA904_0","GLUTATHIONE S-TRANSFERASE OMEGA-1","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"PHE A 338;ARG A 102;LEU A 333;PRO A 335","None","1.39A","3vlnA-2z5lA:undetectable","3vlnA-2z5lA:18.64"],["4CTZ_A_H4BA600_1","NITRIC OXIDE SYNTHASE, ENDOTHELIAL;NITRIC OXIDE SYNTHASE, ENDOTHELIAL","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"VAL A 457;ARG A 429;TRP A 461;PHE A 464","None","1.46A","4ctzA-2z5lA:0.8;4ctzB-2z5lA:0.0","4ctzA-2z5lA:21.56;4ctzB-2z5lA:21.56"],["4D7B_A_TCWA1126_1","TRANSTHYRETIN;TRANSTHYRETIN","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"LEU A 443;ALA A 446;LEU A 444;SER A 234","None","1.21A","4d7bB-2z5lA:undetectable","4d7bB-2z5lA:15.02"],["4DMG_B_SAMB401_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1493","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"TYR A 220;GLU A 197;ALA A 199;ASP A 164;PRO A 166","None","1.31A","4dmgB-2z5lA:6.6","4dmgB-2z5lA:24.14"],["4FEU_D_KAND301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ASP A 326;ASN A 377;GLU A 154;GLU A 423","None","1.03A","4feuD-2z5lA:undetectable","4feuD-2z5lA:20.00"],["4FEV_B_KANB301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ASP A 326;ASN A 377;GLU A 154;GLU A 423","None","1.10A","4fevB-2z5lA:undetectable","4fevB-2z5lA:20.00"],["4FEW_B_KANB301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ASP A 326;ASN A 377;GLU A 154;GLU A 423","None","1.08A","4fewB-2z5lA:undetectable","4fewB-2z5lA:20.00"],["4GKH_D_KAND301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ASP A 326;ASN A 377;GLU A 154;GLU A 423","None","1.06A","4gkhD-2z5lA:undetectable","4gkhD-2z5lA:20.00"],["4IAR_A_ERMA2001_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"ALA A 442;TRP A 412;PHE A 368;LEU A 352;THR A 321","None","1.50A","4iarA-2z5lA:undetectable","4iarA-2z5lA:22.70"],["4IB4_A_ERMA2001_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"VAL A 300;ALA A 357;PHE A 365;LEU A 390;VAL A 318","None","1.25A","4ib4A-2z5lA:undetectable","4ib4A-2z5lA:21.09"],["4NC3_A_ERMA1202_1","CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"VAL A 300;ALA A 357;PHE A 365;LEU A 390;VAL A 318","None","1.23A","4nc3A-2z5lA:undetectable","4nc3A-2z5lA:21.09"],["4PH9_A_IBPA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"VAL A 456;ARG A   7;GLY A 231;ALA A 230;SER A   1","None","1.01A","4ph9A-2z5lA:undetectable","4ph9A-2z5lA:21.93"],["4PH9_B_IBPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"VAL A 456;ARG A   7;GLY A 231;ALA A 230;SER A   1","None","1.01A","4ph9B-2z5lA:undetectable","4ph9B-2z5lA:21.93"],["4UG5_A_H4BA902_1","NITRIC OXIDE SYNTHASE OXYGENASE","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"ARG A 429;THR A 374;TRP A 375","None","1.27A","4ug5A-2z5lA:undetectable","4ug5A-2z5lA:22.35"],["5ECL_A_ILEA602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"ALA A 140;THR A  98;VAL A 101;VAL A 346","None","1.01A","5eclA-2z5lA:0.4","5eclA-2z5lA:21.47"],["5KXI_A_NCTA402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"TYR A   8;THR A 479;TRP A 375;LEU A 476","None","1.39A","5kxiA-2z5lA:undetectable;5kxiB-2z5lA:undetectable","5kxiA-2z5lA:21.02;5kxiB-2z5lA:21.74"],["5KXI_D_NCTD402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"TYR A   8;THR A 479;TRP A 375;LEU A 476","None","1.41A","5kxiD-2z5lA:undetectable;5kxiE-2z5lA:undetectable","5kxiD-2z5lA:21.02;5kxiE-2z5lA:21.74"],["5L4I_B_6J3B201_0","TRANSTHYRETIN","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"LEU A 443;ALA A 446;LEU A 444;SER A 234","None","1.21A","5l4iB-2z5lA:undetectable","5l4iB-2z5lA:14.85"],["5LJE_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"LEU A 266;LEU A 286;ALA A 259;LEU A 443;ARG A 256","None","1.02A","5ljeA-2z5lA:undetectable","5ljeA-2z5lA:13.75"],["5X7F_A_SAMA301_0","PUTATIVE O-METHYLTRANSFERASE RV1220C","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",5,"GLY A 376;GLY A 148;GLY A 146;ILE A 105;ALA A 151","None","1.01A","5x7fA-2z5lA:8.1","5x7fA-2z5lA:25.15"],["6BPL_B_PA1B605_1","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA;LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",3,"ARG A   9;ARG A 398;ARG A 449","None","1.06A","6bplA-2z5lA:undetectable;6bplB-2z5lA:undetectable","6bplA-2z5lA:9.35;6bplB-2z5lA:9.35"],["6CNJ_D_NCTD402_1","NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4;NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2","2z5l","TYLACTONE SYNTHASE STARTER MODULE AND MODULES 1 & 2","Streptomyces fradiae",4,"TYR A   8;THR A 479;TRP A 375;LEU A 476","None","1.40A","6cnjD-2z5lA:undetectable;6cnjE-2z5lA:undetectable","6cnjD-2z5lA:9.56;6cnjE-2z5lA:10.40"]]