SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z5x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.83A 1a7yA-2z5xA:
undetectable		 1a7yA-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.79A 1a7yB-2z5xA:
undetectable		 1a7yB-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.77A 1a7yB-2z5xA:
undetectable		 1a7yB-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.81A 1c6yA-2z5xA:
undetectable		 1c6yA-2z5xA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 8 GLU A  34
LEU A  31
GLU A 453
LEU A  80
 None
 0.99A 1cmaA-2z5xA:
undetectable
1cmaB-2z5xA:
undetectable		 1cmaA-2z5xA:
12.20
1cmaB-2z5xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ARG A  79
LEU A  80
GLU A 453
ALA A 448
GLY A 443
 None
None
None
FAD  A 600 (-3.5A)
FAD  A 600 (-4.3A)
 1.34A 1cmaA-2z5xA:
undetectable
1cmaB-2z5xA:
undetectable		 1cmaA-2z5xA:
12.20
1cmaB-2z5xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 ALA A 448
GLY A 443
ARG A  79
LEU A  80
GLU A 453
 FAD  A 600 (-3.5A)
FAD  A 600 (-4.3A)
None
None
None
 1.31A 1cmcA-2z5xA:
undetectable
1cmcB-2z5xA:
undetectable		 1cmcA-2z5xA:
12.20
1cmcB-2z5xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 ARG A  79
LEU A  80
GLU A 453
ALA A 448
GLY A 443
 None
None
None
FAD  A 600 (-3.5A)
FAD  A 600 (-4.3A)
 1.30A 1cmcA-2z5xA:
undetectable
1cmcB-2z5xA:
undetectable		 1cmcA-2z5xA:
12.20
1cmcB-2z5xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 9 GLU A  83
LEU A 234
GLU A  34
ALA A  28
VAL A  18
 None
 1.22A 1ctrA-2z5xA:
undetectable		 1ctrA-2z5xA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.97A 1dscC-2z5xA:
undetectable		 1dscC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ASP A  64
GLY A 222
VAL A  48
GLY A  49
ILE A  23
 GOL  A 702 (-3.6A)
GOL  A 702 (-3.6A)
None
FAD  A 600 (-4.9A)
FAD  A 600 (-4.9A)
 0.88A 1fb7A-2z5xA:
undetectable		 1fb7A-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.83A 1fjaC-2z5xA:
undetectable		 1fjaC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.84A 1fjaD-2z5xA:
undetectable		 1fjaD-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ILE A 131
ASN A 125
PHE A 112
GLY A 203
ASP A 132
 None
 1.12A 1ho5A-2z5xA:
undetectable		 1ho5A-2z5xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.89A 1hxwB-2z5xA:
undetectable		 1hxwB-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.84A 1i3wE-2z5xA:
undetectable		 1i3wE-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.79A 1i3wE-2z5xA:
undetectable		 1i3wE-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.83A 1i3wF-2z5xA:
undetectable		 1i3wF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.78A 1i3wG-2z5xA:
undetectable		 1i3wG-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.81A 1i3wG-2z5xA:
undetectable		 1i3wG-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.80A 1i3wH-2z5xA:
undetectable		 1i3wH-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.84A 1mnvD-2z5xA:
undetectable		 1mnvD-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.83A 1mnvD-2z5xA:
undetectable		 1mnvD-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.80A 1qfiB-2z5xA:
undetectable		 1qfiB-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 7 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.03A 1rxcF-2z5xA:
undetectable		 1rxcF-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 7 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.06A 1rxcL-2z5xA:
undetectable		 1rxcL-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.77A 1t7jA-2z5xA:
undetectable		 1t7jA-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.73A 1unjF-2z5xA:
undetectable		 1unjF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.81A 1unjF-2z5xA:
undetectable		 1unjF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.76A 1unjL-2z5xA:
undetectable		 1unjL-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.81A 1unjL-2z5xA:
undetectable		 1unjL-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.80A 1unjR-2z5xA:
undetectable		 1unjR-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.79A 1unjR-2z5xA:
undetectable		 1unjR-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.82A 1unjW-2z5xA:
undetectable		 1unjW-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.77A 1unjX-2z5xA:
undetectable		 1unjX-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.80A 1unjX-2z5xA:
undetectable		 1unjX-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.77A 1unmE-2z5xA:
undetectable		 1unmE-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.81A 1unmE-2z5xA:
undetectable		 1unmE-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.81A 1unmF-2z5xA:
undetectable		 1unmF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.78A 1unmF-2z5xA:
undetectable		 1unmF-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 4 LEU A 233
LEU A  26
SER A  27
LEU A  80
 None
 1.11A 1ya3A-2z5xA:
undetectable		 1ya3A-2z5xA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.82A 209dC-2z5xA:
undetectable		 209dC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 276
THR A 278
PRO A 274
 None
None
FAD  A 600 ( 4.9A)
 0.75A 209dC-2z5xA:
undetectable		 209dC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		6 / 11 GLY A 452
ALA A 433
ILE A 273
GLY A  21
VAL A  16
ILE A 270
 None
None
FAD  A 600 (-3.9A)
FAD  A 600 ( 4.6A)
None
None
 1.18A 2aquB-2z5xA:
undetectable		 2aquB-2z5xA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 PHE A 411
GLY A 434
THR A 435
ALA A 438
ALA A 451
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 1.06A 2ej3B-2z5xA:
undetectable		 2ej3B-2z5xA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.87A 2o4pB-2z5xA:
undetectable		 2o4pB-2z5xA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 4 LEU A 381
LEU A 387
MET A 324
MET A 308
 None
 1.43A 2oaxB-2z5xA:
0.0		 2oaxB-2z5xA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 ILE A  19
ILE A 430
LEU A 234
 FAD  A 600 (-4.7A)
None
None
 0.47A 2prgA-2z5xA:
undetectable		 2prgA-2z5xA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.85A 2q63A-2z5xA:
undetectable		 2q63A-2z5xA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.82A 2q64B-2z5xA:
undetectable		 2q64B-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.88A 2qakA-2z5xA:
undetectable		 2qakA-2z5xA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 ARG A 424
ILE A 415
GLN A 418
GLU A 290
 None
 1.44A 2ya7C-2z5xA:
undetectable		 2ya7C-2z5xA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.82A 316dC-2z5xA:
undetectable		 316dC-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.84A 3bvbB-2z5xA:
undetectable		 3bvbB-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 5 ASN A 271
ALA A  44
GLY A  22
THR A 408
 None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.2A)
None
 0.86A 3dl9A-2z5xA:
undetectable		 3dl9A-2z5xA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.84A 3ekpB-2z5xA:
undetectable		 3ekpB-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.82A 3ekpC-2z5xA:
undetectable		 3ekpC-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.82A 3ekpD-2z5xA:
undetectable		 3ekpD-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.81A 3ektA-2z5xA:
undetectable		 3ektA-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.82A 3ektC-2z5xA:
undetectable		 3ektC-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 ALA A  28
ALA A  29
ALA A 456
VAL A 244
ILE A 256
 None
None
None
FAD  A 600 ( 4.0A)
None
 1.13A 3falA-2z5xA:
undetectable		 3falA-2z5xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 SER A  24
GLY A 452
GLY A  25
VAL A 247
ILE A 430
 FAD  A 600 (-4.2A)
None
None
None
None
 0.94A 3gczA-2z5xA:
undetectable		 3gczA-2z5xA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ASN A  92
THR A 105
ASP A 338
ILE A 349
LEU A 381
 None
 1.30A 3iv6A-2z5xA:
2.9		 3iv6A-2z5xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.81A 3jw2B-2z5xA:
undetectable		 3jw2B-2z5xA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.09A 3kvvA-2z5xA:
undetectable		 3kvvA-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.10A 3kvvB-2z5xA:
undetectable		 3kvvB-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.12A 3kvvC-2z5xA:
undetectable		 3kvvC-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.11A 3kvvD-2z5xA:
undetectable		 3kvvD-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.10A 3kvvE-2z5xA:
undetectable		 3kvvE-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.07A 3kvvF-2z5xA:
undetectable		 3kvvF-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.90A 3lzuB-2z5xA:
undetectable		 3lzuB-2z5xA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 ALA A  29
VAL A 238
GLY A  22
ILE A  23
LEU A 234
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
None
 1.21A 3ogpB-2z5xA:
undetectable		 3ogpB-2z5xA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		6 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
LEU A 234
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
None
 1.33A 3ogqA-2z5xA:
undetectable		 3ogqA-2z5xA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.95A 3oy4A-2z5xA:
undetectable		 3oy4A-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.75A 3oy4B-2z5xA:
undetectable		 3oy4B-2z5xA:
12.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 8 TYR A  69
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 600 (-4.2A)
HRM  A 700 (-3.4A)
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.24A 3po7A-2z5xA:
62.6		 3po7A-2z5xA:
72.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PO7_B_ZONB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		6 / 9 TYR A  69
ILE A 207
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 600 (-4.2A)
None
HRM  A 700 (-3.4A)
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.23A 3po7B-2z5xA:
62.8		 3po7B-2z5xA:
72.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 8 GLY A  25
PRO A 274
GLU A 436
ARG A  45
 None
FAD  A 600 ( 4.9A)
None
FAD  A 600 ( 3.8A)
 0.88A 3s3mA-2z5xA:
undetectable		 3s3mA-2z5xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.93A 3so9B-2z5xA:
undetectable		 3so9B-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 7 LEU A 233
ALA A  29
GLY A  22
ILE A  23
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.85A 3spkB-2z5xA:
undetectable		 3spkB-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.77A 3spkA-2z5xA:
undetectable		 3spkA-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.87A 3spkB-2z5xA:
undetectable		 3spkB-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A  44
HIS A 242
LEU A 240
GLY A  20
ALA A 448
 FAD  A 600 (-3.3A)
None
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.5A)
 1.32A 3tm4A-2z5xA:
4.0		 3tm4A-2z5xA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 CYH A 406
THR A  54
SER A 223
VAL A 303
PHE A 352
 FAD  A 600 (-1.6A)
None
None
FAD  A 600 ( 4.7A)
HRM  A 700 (-4.3A)
 1.47A 3u9fA-2z5xA:
0.0
3u9fC-2z5xA:
0.0		 3u9fA-2z5xA:
16.18
3u9fC-2z5xA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 THR A  54
SER A 223
VAL A 303
PHE A 352
CYH A 406
 None
None
FAD  A 600 ( 4.7A)
HRM  A 700 (-4.3A)
FAD  A 600 (-1.6A)
 1.45A 3u9fH-2z5xA:
undetectable
3u9fI-2z5xA:
undetectable		 3u9fH-2z5xA:
16.18
3u9fI-2z5xA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 CYH A 406
THR A  54
SER A 223
VAL A 303
PHE A 352
 FAD  A 600 (-1.6A)
None
None
FAD  A 600 ( 4.7A)
HRM  A 700 (-4.3A)
 1.49A 3u9fJ-2z5xA:
undetectable
3u9fL-2z5xA:
undetectable		 3u9fJ-2z5xA:
16.18
3u9fL-2z5xA:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		7 / 12 PRO A 113
TRP A 128
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
HRM  A 700 (-3.4A)
None
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.49A 4a79A-2z5xA:
61.5		 4a79A-2z5xA:
72.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		7 / 12 PRO A 113
TRP A 128
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
HRM  A 700 (-3.4A)
None
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.55A 4a79B-2z5xA:
61.8		 4a79B-2z5xA:
72.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		6 / 11 TYR A  69
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 FAD  A 600 (-4.2A)
HRM  A 700 (-3.4A)
None
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.21A 4a7aA-2z5xA:
61.7		 4a7aA-2z5xA:
72.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		7 / 12 PRO A 113
LEU A 176
GLN A 215
ILE A 325
PHE A 352
TYR A 407
TYR A 444
 None
None
HRM  A 700 (-3.4A)
None
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.48A 4a7aB-2z5xA:
62.1		 4a7aB-2z5xA:
72.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 TYR A 410
MET A 300
ILE A 273
 None
None
FAD  A 600 (-3.9A)
 0.72A 4c8bB-2z5xA:
undetectable		 4c8bB-2z5xA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 0.76A 4cpzC-2z5xA:
undetectable		 4cpzC-2z5xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 0.79A 4cpzE-2z5xA:
undetectable		 4cpzE-2z5xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 ARG A 454
ARG A 457
TRP A 472
 None
 0.76A 4cpzH-2z5xA:
undetectable		 4cpzH-2z5xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.78A 4dqbB-2z5xA:
undetectable		 4dqbB-2z5xA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.80A 4dqcB-2z5xA:
undetectable		 4dqcB-2z5xA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.97A 4dqeA-2z5xA:
undetectable		 4dqeA-2z5xA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.78A 4dqeB-2z5xA:
undetectable		 4dqeB-2z5xA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.97A 4dqhA-2z5xA:
undetectable		 4dqhA-2z5xA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.78A 4dqhB-2z5xA:
undetectable		 4dqhB-2z5xA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 7 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.06A 4e1vB-2z5xA:
undetectable		 4e1vB-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 GLY A 447
GLN A  74
ILE A  23
VAL A 449
 None
FAD  A 600 ( 4.7A)
FAD  A 600 (-4.9A)
None
 1.05A 4e1vF-2z5xA:
undetectable		 4e1vF-2z5xA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 THR A 278
PRO A 274
THR A 276
 None
FAD  A 600 ( 4.9A)
None
 0.81A 4hivD-2z5xA:
undetectable		 4hivD-2z5xA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 LYS A 280
LEU A 277
ALA A 279
 None
FAD  A 600 (-4.1A)
None
 0.66A 4ikiA-2z5xA:
undetectable		 4ikiA-2z5xA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 VAL A 220
GLY A 222
LYS A 218
 None
GOL  A 702 (-3.6A)
GOL  A 702 (-3.1A)
 0.71A 4k50A-2z5xA:
undetectable		 4k50A-2z5xA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 VAL A 220
GLY A 222
LYS A 218
 None
GOL  A 702 (-3.6A)
GOL  A 702 (-3.1A)
 0.66A 4k50E-2z5xA:
undetectable		 4k50E-2z5xA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 VAL A 220
GLY A 222
LYS A 218
 None
GOL  A 702 (-3.6A)
GOL  A 702 (-3.1A)
 0.73A 4k50I-2z5xA:
undetectable		 4k50I-2z5xA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 6 TYR A 124
PRO A 114
PHE A 208
PHE A 108
 None
None
HRM  A 700 (-3.5A)
None
 1.34A 4kf9A-2z5xA:
undetectable		 4kf9A-2z5xA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.85A 4ll3B-2z5xA:
undetectable		 4ll3B-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.88A 4ll3A-2z5xA:
undetectable		 4ll3A-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 8 VAL A  37
LEU A 460
LEU A 463
TYR A 268
ILE A 270
 None
 1.40A 4lzrA-2z5xA:
undetectable		 4lzrA-2z5xA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.77A 4njtB-2z5xA:
undetectable		 4njtB-2z5xA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.92A 4njuA-2z5xA:
undetectable		 4njuA-2z5xA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.92A 4njuC-2z5xA:
undetectable		 4njuC-2z5xA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 GLY A  22
MET A 445
LEU A  80
GLN A 225
THR A  54
 FAD  A 600 (-3.2A)
FAD  A 600 (-4.3A)
None
None
None
 1.44A 4p6xA-2z5xA:
undetectable		 4p6xA-2z5xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.80A 4qgiB-2z5xA:
undetectable		 4qgiB-2z5xA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 4qvpH-2z5xA:
undetectable
4qvpI-2z5xA:
undetectable		 4qvpH-2z5xA:
18.93
4qvpI-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 GLN A  74
ALA A 433
THR A 435
ALA A 438
THR A 437
 FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.4A)
None
None
 1.15A 4qvpH-2z5xA:
undetectable
4qvpI-2z5xA:
undetectable		 4qvpH-2z5xA:
18.93
4qvpI-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 4qvpV-2z5xA:
undetectable
4qvpW-2z5xA:
undetectable		 4qvpV-2z5xA:
18.93
4qvpW-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 GLN A  74
ALA A 433
THR A 435
ALA A 438
THR A 437
 FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.4A)
None
None
 1.15A 4qvpV-2z5xA:
undetectable
4qvpW-2z5xA:
undetectable		 4qvpV-2z5xA:
18.93
4qvpW-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 4qvvH-2z5xA:
undetectable		 4qvvH-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 THR A 439
GLN A 200
ALA A 433
GLY A 434
THR A 435
 None
None
None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
 1.14A 4qvvH-2z5xA:
undetectable		 4qvvH-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 4qvvV-2z5xA:
undetectable		 4qvvV-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 THR A 439
GLN A 200
ALA A 433
GLY A 434
THR A 435
 None
None
None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
 1.13A 4qvvV-2z5xA:
undetectable		 4qvvV-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 4qvyH-2z5xA:
undetectable		 4qvyH-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 THR A 439
GLN A 200
ALA A 433
GLY A 434
THR A 435
 None
None
None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
 1.12A 4qvyH-2z5xA:
undetectable		 4qvyH-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 4qvyV-2z5xA:
undetectable
4qvyW-2z5xA:
undetectable		 4qvyV-2z5xA:
18.93
4qvyW-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 4qw0H-2z5xA:
undetectable
4qw0I-2z5xA:
undetectable		 4qw0H-2z5xA:
18.93
4qw0I-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 4qw0V-2z5xA:
undetectable
4qw0W-2z5xA:
undetectable		 4qw0V-2z5xA:
18.93
4qw0W-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.94A 4qw1H-2z5xA:
undetectable
4qw1I-2z5xA:
undetectable		 4qw1H-2z5xA:
18.93
4qw1I-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 4qw1V-2z5xA:
undetectable
4qw1W-2z5xA:
undetectable		 4qw1V-2z5xA:
18.93
4qw1W-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 10 GLN A  74
ALA A 433
THR A 435
ALA A 438
THR A 437
 FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.4A)
None
None
 1.16A 4qw3H-2z5xA:
0.0
4qw3I-2z5xA:
undetectable		 4qw3H-2z5xA:
18.93
4qw3I-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 GLN A  74
ALA A 433
THR A 435
ALA A 438
THR A 437
 FAD  A 600 ( 4.7A)
None
FAD  A 600 (-3.4A)
None
None
 1.15A 4qw3V-2z5xA:
0.0
4qw3W-2z5xA:
undetectable		 4qw3V-2z5xA:
18.93
4qw3W-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 8 ALA A 331
GLY A 103
THR A 105
VAL A  98
 None
 0.78A 4r20A-2z5xA:
undetectable		 4r20A-2z5xA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 8 ALA A  28
VAL A  18
GLY A 452
ALA A 451
GLY A 434
 None
None
None
None
FAD  A 600 (-3.1A)
 1.45A 4zjzB-2z5xA:
undetectable		 4zjzB-2z5xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 5 ALA A 448
ARG A  51
ALA A 272
GLU A 436
 FAD  A 600 (-3.5A)
FAD  A 600 (-3.7A)
None
None
 1.25A 5a06C-2z5xA:
undetectable
5a06D-2z5xA:
undetectable		 5a06C-2z5xA:
20.40
5a06D-2z5xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 5 ALA A 448
ARG A  51
ALA A 433
GLU A 436
 FAD  A 600 (-3.5A)
FAD  A 600 (-3.7A)
None
None
 1.11A 5a06C-2z5xA:
undetectable
5a06D-2z5xA:
undetectable		 5a06C-2z5xA:
20.40
5a06D-2z5xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 5bxnH-2z5xA:
undetectable
5bxnI-2z5xA:
undetectable		 5bxnH-2z5xA:
18.93
5bxnI-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 5cz7V-2z5xA:
undetectable
5cz7W-2z5xA:
undetectable		 5cz7V-2z5xA:
18.93
5cz7W-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 5d0xV-2z5xA:
undetectable		 5d0xV-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 THR A 439
GLN A 200
ALA A 433
GLY A 434
THR A 435
 None
None
None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
 1.13A 5d0xV-2z5xA:
undetectable		 5d0xV-2z5xA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ILE A 161
VAL A 189
HIS A 187
ALA A 302
VAL A 182
 None
 0.99A 5igtA-2z5xA:
undetectable		 5igtA-2z5xA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 8 SER A 442
THR A 408
PRO A 143
ILE A 423
 None
 1.08A 5jhdE-2z5xA:
undetectable
5jhdG-2z5xA:
undetectable		 5jhdE-2z5xA:
19.96
5jhdG-2z5xA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 9 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.82A 5kr0B-2z5xA:
undetectable		 5kr0B-2z5xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 5l5fH-2z5xA:
undetectable
5l5fI-2z5xA:
undetectable		 5l5fH-2z5xA:
18.93
5l5fI-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.95A 5l5fV-2z5xA:
undetectable
5l5fW-2z5xA:
undetectable		 5l5fV-2z5xA:
18.93
5l5fW-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 5l66H-2z5xA:
undetectable
5l66I-2z5xA:
undetectable		 5l66H-2z5xA:
18.93
5l66I-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 5l66V-2z5xA:
undetectable
5l66W-2z5xA:
undetectable		 5l66V-2z5xA:
18.93
5l66W-2z5xA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 VAL A 473
GLU A 453
GLY A 452
ALA A 272
ALA A 455
 None
 1.20A 5n5dA-2z5xA:
undetectable		 5n5dA-2z5xA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
 0.79A 5t2zB-2z5xA:
undetectable		 5t2zB-2z5xA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		6 / 12 GLY A  25
GLY A 452
VAL A  41
ILE A  23
LEU A  26
LEU A 234
 None
None
None
FAD  A 600 (-4.9A)
None
None
 1.22A 5wy0A-2z5xA:
undetectable		 5wy0A-2z5xA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		4 / 7 ALA A 433
GLY A  25
GLY A  20
THR A 437
 None
None
FAD  A 600 (-3.3A)
None
 0.75A 5ybbB-2z5xA:
undetectable		 5ybbB-2z5xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 MET A 445
ASP A  64
ARG A  45
 FAD  A 600 (-4.3A)
GOL  A 702 (-3.6A)
FAD  A 600 ( 3.8A)
 1.08A 5z6kA-2z5xA:
undetectable		 5z6kA-2z5xA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		3 / 3 ALA A 302
VAL A 189
TYR A 410
 None
 0.68A 5zmqH-2z5xA:
undetectable		 5zmqH-2z5xA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 12 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.96A 6hwdH-2z5xA:
undetectable
6hwdI-2z5xA:
undetectable		 6hwdH-2z5xA:
10.79
6hwdI-2z5xA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A
(Homo
sapiens) 		5 / 11 ALA A 433
GLY A 434
THR A 435
ALA A 438
THR A 437
 None
FAD  A 600 (-3.1A)
FAD  A 600 (-3.4A)
None
None
 0.97A 6hwdV-2z5xA:
undetectable		 6hwdV-2z5xA:
10.79