SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 321
GLY A 335
ILE A 336
ILE A  17
 None
 0.68A 1d4yB-2z61A:
undetectable		 1d4yB-2z61A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 191
ILE A 217
TYR A 224
ILE A  47
ALA A 266
 LLP  A 222 ( 4.4A)
None
None
None
None
 1.20A 1jtxA-2z61A:
undetectable		 1jtxA-2z61A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A 236
ASN A  91
ILE A 241
GLU A 212
 None
 0.72A 1meiA-2z61A:
undetectable		 1meiA-2z61A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 11 ARG A  72
ARG A  66
LEU A 245
GLU A 242
ALA A 243
 None
 1.23A 1mjlA-2z61A:
undetectable
1mjlB-2z61A:
undetectable		 1mjlA-2z61A:
15.15
1mjlB-2z61A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 317
GLY A 335
LEU A 332
PHE A 320
TRP A 298
 None
 1.18A 1qzzA-2z61A:
2.9		 1qzzA-2z61A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.78A 2nnkA-2z61A:
undetectable		 2nnkA-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 279
PHE A 267
LEU A  78
PHE A 220
TYR A 224
 None
 1.46A 3apwB-2z61A:
undetectable		 3apwB-2z61A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  97
GLY A 219
GLY A 232
 LLP  A 222 ( 3.8A)
None
None
 0.44A 3bogC-2z61A:
undetectable		 3bogC-2z61A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A  97
GLY A 219
GLY A 232
 LLP  A 222 ( 3.8A)
None
None
 0.37A 3bogD-2z61A:
undetectable		 3bogD-2z61A:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.73A 3k4vA-2z61A:
undetectable		 3k4vA-2z61A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.70A 3k4vD-2z61A:
undetectable		 3k4vD-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.67A 3nduD-2z61A:
undetectable		 3nduD-2z61A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.84A 3pwrA-2z61A:
undetectable		 3pwrA-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.73A 3tl9A-2z61A:
undetectable		 3tl9A-2z61A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 351
TYR A 308
ARG A 286
ALA A 306
 None
 1.13A 3twpC-2z61A:
undetectable		 3twpC-2z61A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A  68
GLN A 260
ILE A 258
TYR A 261
 None
 1.13A 4a99D-2z61A:
undetectable		 4a99D-2z61A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.04A 4mi4B-2z61A:
undetectable
4mi4C-2z61A:
undetectable		 4mi4B-2z61A:
21.88
4mi4C-2z61A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.03A 4mi4A-2z61A:
undetectable
4mi4C-2z61A:
undetectable		 4mi4A-2z61A:
21.88
4mi4C-2z61A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 8 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.04A 4mj8A-2z61A:
undetectable
4mj8C-2z61A:
undetectable		 4mj8A-2z61A:
21.47
4mj8C-2z61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 8 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.03A 4mj8B-2z61A:
undetectable
4mj8C-2z61A:
undetectable		 4mj8B-2z61A:
21.47
4mj8C-2z61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.03A 4mj8C-2z61A:
undetectable		 4mj8C-2z61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.03A 4r87I-2z61A:
undetectable		 4r87I-2z61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 165
PRO A 166
PHE A 310
TYR A 350
 LLP  A 222 ( 3.8A)
None
None
None
 1.40A 5amhA-2z61A:
undetectable		 5amhA-2z61A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 PRO A  89
ARG A  72
GLU A  73
 None
 0.89A 5j6hA-2z61A:
undetectable		 5j6hA-2z61A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.03A 5lg3A-2z61A:
undetectable		 5lg3A-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.04A 5lg3E-2z61A:
undetectable		 5lg3E-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.03A 5lg3F-2z61A:
undetectable		 5lg3F-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.02A 5lg3G-2z61A:
undetectable		 5lg3G-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.02A 5lg3H-2z61A:
undetectable		 5lg3H-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 217
ILE A 187
VAL A 234
ASN A 237
ILE A 240
 None
 1.05A 5lg3J-2z61A:
undetectable		 5lg3J-2z61A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 9 ILE A 346
VAL A 293
GLU A 315
LEU A 368
ILE A 364
 None
 1.35A 5mzpA-2z61A:
undetectable		 5mzpA-2z61A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 203
ALA A 204
THR A 214
 None
 0.57A 5n0xB-2z61A:
undetectable		 5n0xB-2z61A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 165
PRO A 166
PHE A 310
TYR A 350
 LLP  A 222 ( 3.8A)
None
None
None
 1.26A 5oh3A-2z61A:
undetectable		 5oh3A-2z61A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 116
LYS A 136
ILE A 110
LYS A 154
 None
 1.16A 5q1sA-2z61A:
2.9		 5q1sA-2z61A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A  54
GLY A  51
ILE A 231
ALA A 263
LEU A 264
 None
 1.14A 5zjiA-2z61A:
undetectable
5zjiJ-2z61A:
undetectable		 5zjiA-2z61A:
11.89
5zjiJ-2z61A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2
(Methanocaldococc
us
jannaschii) 		5 / 12 MET A  15
VAL A  31
VAL A 330
GLU A  25
SER A  26
 None
 1.28A 6bzoC-2z61A:
undetectable		 6bzoC-2z61A:
16.68