SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z65'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 180
LEU A 208
MET A 201
VAL A 197
LEU A 152
 None
 1.16A 1gs4A-2z65A:
undetectable		 1gs4A-2z65A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU A 174
LEU A 152
LEU A 180
LEU A 198
 None
 1.05A 2ab2A-2z65A:
undetectable		 2ab2A-2z65A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 0.94A 2bfpA-2z65A:
undetectable		 2bfpA-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 0.92A 2bfpB-2z65A:
undetectable		 2bfpB-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 1.00A 2bfpC-2z65A:
undetectable		 2bfpC-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 165
LEU A 195
LEU A 231
LEU A 233
 None
 1.02A 2bfpD-2z65A:
undetectable		 2bfpD-2z65A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 ALA A 121
ALA A  97
LEU A  69
SER A 116
LEU A 117
 None
 1.09A 2bxeB-2z65A:
undetectable		 2bxeB-2z65A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 10 LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
 None
 1.07A 2bxeB-2z65A:
undetectable		 2bxeB-2z65A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 PHE A 171
LEU A 180
LEU A 208
GLU A 142
 None
 0.95A 2jn3A-2z65A:
undetectable		 2jn3A-2z65A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2z65 LYMPHOCYTE ANTIGEN
96
(Homo
sapiens) 		5 / 9 ILE C  46
ILE C  63
PHE C 151
ALA C 137
LEU C 149
 E55  C   1 (-4.6A)
E55  C   1 ( 4.5A)
E55  C   1 (-3.9A)
None
None
 1.15A 2m9qA-2z65C:
undetectable		 2m9qA-2z65C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 10 ILE A  93
PHE A 144
LEU A 107
VAL A 132
LEU A 131
 None
 1.44A 2w98A-2z65A:
undetectable		 2w98A-2z65A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 ILE A 146
LEU A 131
ALA A 133
THR A 136
LEU A 117
 None
 1.14A 3a50A-2z65A:
undetectable		 3a50A-2z65A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 SER A  71
LEU A 117
GLY A 120
GLU A  94
 None
 1.07A 3aiaA-2z65A:
undetectable
3aiaB-2z65A:
undetectable		 3aiaA-2z65A:
25.70
3aiaB-2z65A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
LYMPHOCYTE ANTIGEN
96
(Eptatretus
burgeri;
Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR C  36
GLU A  42
ASP A  60
 None
 0.80A 3bxoA-2z65C:
undetectable		 3bxoA-2z65C:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
LYMPHOCYTE ANTIGEN
96
(Eptatretus
burgeri;
Homo
sapiens;
Homo
sapiens) 		3 / 3 TYR C  36
GLU A  42
ASP A  60
 None
 0.78A 3bxoB-2z65C:
undetectable		 3bxoB-2z65C:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 LEU A 249
MET A 201
ILE A 187
ASP A 181
 None
 1.48A 3hecA-2z65A:
undetectable		 3hecA-2z65A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2z65 LYMPHOCYTE ANTIGEN
96
(Homo
sapiens) 		3 / 3 SER C 141
GLY C 140
GLN C  73
 None
 0.39A 3v4tH-2z65C:
undetectable		 3v4tH-2z65C:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 155
LEU A 180
LEU A 208
MET A 201
VAL A 197
 None
 1.26A 3zqtA-2z65A:
undetectable		 3zqtA-2z65A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 165
ALA A 222
LEU A 231
LEU A 210
 None
 0.82A 4ejgB-2z65A:
undetectable		 4ejgB-2z65A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 PHE A 165
ALA A 222
LEU A 231
LEU A 210
 None
 0.85A 4ejgC-2z65A:
undetectable		 4ejgC-2z65A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		6 / 12 ILE A 218
ILE A 255
PHE A 223
LEU A 208
LEU A 195
ILE A 190
 None
 1.44A 4m2xA-2z65A:
undetectable		 4m2xA-2z65A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 GLY A  70
LEU A 101
ILE A  48
LEU A  85
 None
 0.86A 4o8fA-2z65A:
undetectable		 4o8fA-2z65A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2z65 LYMPHOCYTE ANTIGEN
96
TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY C 110
TYR C  42
GLU A  42
PHE A  63
ASN A  64
 None
 1.22A 4pd5A-2z65C:
undetectable		 4pd5A-2z65C:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2z65 LYMPHOCYTE ANTIGEN
96
TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 GLY C 110
TYR C  42
GLU A  42
PHE A  63
ASN A  64
 None
 1.20A 4pd9A-2z65C:
undetectable		 4pd9A-2z65C:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE A 246
ILE A 218
LEU A 238
LEU A 276
LEU A 272
 None
 1.18A 4qynB-2z65A:
undetectable		 4qynB-2z65A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE A 246
ILE A 218
LEU A 238
LEU A 276
LEU A 272
 None
 1.16A 4qzuC-2z65A:
undetectable		 4qzuC-2z65A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 2z65 LYMPHOCYTE ANTIGEN
96
TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 PHE A  63
ASP A  84
GLY C 110
SER A  62
 None
 1.38A 4xp9C-2z65A:
undetectable		 4xp9C-2z65A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 PHE A 223
ILE A 218
ASP A 243
 None
 0.75A 5cswA-2z65A:
undetectable		 5cswA-2z65A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2z65 LYMPHOCYTE ANTIGEN
96
(Homo
sapiens) 		4 / 8 ILE C 124
ILE C  52
ALA C  30
ILE C 153
 E55  C   1 ( 4.9A)
E55  C   1 ( 4.5A)
None
E55  C   1 ( 4.8A)
 0.72A 5mvmA-2z65C:
undetectable
5mvmB-2z65C:
undetectable		 5mvmA-2z65C:
22.82
5mvmB-2z65C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z65 LYMPHOCYTE ANTIGEN
96
(Homo
sapiens) 		4 / 7 THR C 115
PHE C 104
VAL C 113
ILE C  46
 None
E55  C   1 (-4.4A)
None
E55  C   1 (-4.6A)
 1.08A 5vkqA-2z65C:
undetectable
5vkqB-2z65C:
undetectable		 5vkqA-2z65C:
5.28
5vkqB-2z65C:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z65 LYMPHOCYTE ANTIGEN
96
(Homo
sapiens) 		4 / 8 THR C 115
PHE C 104
VAL C 113
ILE C  46
 None
E55  C   1 (-4.4A)
None
E55  C   1 (-4.6A)
 1.07A 5vkqB-2z65C:
undetectable
5vkqC-2z65C:
undetectable		 5vkqB-2z65C:
5.28
5vkqC-2z65C:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z65 LYMPHOCYTE ANTIGEN
96
(Homo
sapiens) 		4 / 7 THR C 115
PHE C 104
VAL C 113
ILE C  46
 None
E55  C   1 (-4.4A)
None
E55  C   1 (-4.6A)
 1.07A 5vkqC-2z65C:
undetectable
5vkqD-2z65C:
undetectable		 5vkqC-2z65C:
5.28
5vkqD-2z65C:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 ASP A 247
LEU A 208
LEU A 195
ALA A 222
PRO A 242
 None
 1.06A 6b0iB-2z65A:
undetectable		 6b0iB-2z65A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ALA A  97
ILE A 108
PHE A 122
LEU A 107
 None
 0.87A 6b5vA-2z65A:
undetectable
6b5vB-2z65A:
undetectable		 6b5vA-2z65A:
17.09
6b5vB-2z65A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ALA A 222
PHE A 246
LEU A 231
ILE A 162
 None
 0.88A 6b5vA-2z65A:
undetectable
6b5vB-2z65A:
undetectable		 6b5vA-2z65A:
17.09
6b5vB-2z65A:
17.09