SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 ASP A 395
HIS A  68
ASP A  72
 None
 0.58A 1nw5A-2z66A:
undetectable		 1nw5A-2z66A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 ILE A 491
LEU A 473
PHE A 467
SER A 455
ILE A 454
 None
 1.34A 1rh3A-2z66A:
undetectable		 1rh3A-2z66A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
 None
 1.48A 1sqnA-2z66A:
undetectable		 1sqnA-2z66A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 532
LEU A 511
LEU A 525
LEU A 549
 None
 1.00A 2bfpA-2z66A:
undetectable		 2bfpA-2z66A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU A 424
PHE A 443
LEU A 404
PHE A 396
 None
 1.03A 2dysC-2z66A:
undetectable
2dysJ-2z66A:
undetectable		 2dysC-2z66A:
21.77
2dysJ-2z66A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 ILE A 466
GLY A 469
LEU A 476
GLY A 465
GLU A 494
 None
 1.14A 2fn1A-2z66A:
undetectable		 2fn1A-2z66A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU A 519
LEU A 495
ILE A 466
SER A 441
 None
 1.19A 2hc4A-2z66A:
undetectable		 2hc4A-2z66A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
 None
 1.47A 2w8yB-2z66A:
undetectable		 2w8yB-2z66A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 VAL A 475
SER A 528
TYR A 451
VAL A 524
 None
NAG  A1431 ( 3.7A)
None
None
 0.87A 2y05A-2z66A:
undetectable
2y05B-2z66A:
undetectable		 2y05A-2z66A:
20.33
2y05B-2z66A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 SER A 415
GLY A 389
SER A 392
 None
 0.57A 3loqA-2z66A:
undetectable		 3loqA-2z66A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 PHE A 492
PHE A 483
THR A 459
LEU A 476
 None
 1.10A 3t3zC-2z66A:
undetectable		 3t3zC-2z66A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 PHE A 581
THR A 537
LEU A 601
 None
 0.74A 4qztA-2z66A:
undetectable		 4qztA-2z66A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 LEU A 564
TRP A 593
ILE A 594
LEU A 549
LEU A 574
 None
 1.28A 4yvpA-2z66A:
undetectable		 4yvpA-2z66A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 564
TRP A 593
ILE A 594
LEU A 549
LEU A 574
 None
 1.36A 4yvpB-2z66A:
undetectable		 4yvpB-2z66A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 THR A 459
ILE A 454
GLY A 480
LEU A 508
LEU A 488
 None
 1.36A 4ze0A-2z66A:
undetectable		 4ze0A-2z66A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 TYR A 551
LEU A 503
LEU A 522
LEU A 546
LEU A 501
 None
 0.95A 4zowA-2z66A:
undetectable		 4zowA-2z66A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU A  80
ILE A  35
PHE A  71
LEU A  63
 None
 0.72A 5eseA-2z66A:
undetectable		 5eseA-2z66A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 LEU A 511
TYR A 551
SER A 534
 None
 0.83A 5iktA-2z66A:
undetectable		 5iktA-2z66A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU A 424
PHE A 443
LEU A 404
PHE A 396
 None
 1.11A 5w97C-2z66A:
undetectable
5w97J-2z66A:
undetectable		 5w97C-2z66A:
21.77
5w97J-2z66A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 LEU A 424
PHE A 443
LEU A 404
PHE A 396
 None
 1.03A 5x1fC-2z66A:
undetectable
5x1fJ-2z66A:
undetectable		 5x1fC-2z66A:
21.77
5x1fJ-2z66A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 TYR A 451
ASP A 405
ASP A 453
 None
 0.59A 5x6yA-2z66A:
undetectable		 5x6yA-2z66A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 LEU A 424
PHE A 443
LEU A 404
PHE A 396
 None
 1.14A 5xdxC-2z66A:
undetectable
5xdxJ-2z66A:
undetectable		 5xdxC-2z66A:
21.77
5xdxJ-2z66A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 LEU A 424
PHE A 443
LEU A 404
PHE A 396
 None
 1.18A 5xdxP-2z66A:
undetectable
5xdxW-2z66A:
undetectable		 5xdxP-2z66A:
21.77
5xdxW-2z66A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU A  77
ALA A  53
LEU A  82
ASN A  38
 None
 0.96A 6f88B-2z66A:
undetectable		 6f88B-2z66A:
12.58