SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 12 TYR A 257
ALA A 249
SER A 275
GLY A 287
LEU A 288
 None
PLP  A1001 (-3.4A)
None
None
None
 1.00A 1fe2A-2z67A:
undetectable		 1fe2A-2z67A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 12 ALA A 251
THR A 139
SER A 142
ILE A 143
LEU A 216
 None
PLP  A1001 (-3.4A)
None
None
None
 1.13A 1rg7A-2z67A:
undetectable		 1rg7A-2z67A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 11 LEU A 280
ILE A 252
LEU A 258
TYR A 290
GLY A 248
 None
 1.19A 2bxmA-2z67A:
undetectable		 2bxmA-2z67A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		4 / 7 VAL A 314
VAL A 318
LEU A 321
SER A 322
 None
 0.89A 3hs6B-2z67A:
0.3		 3hs6B-2z67A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		4 / 6 ARG A 268
SER A 291
PHE A 296
PRO A 243
 None
 1.40A 3jqaB-2z67A:
3.9		 3jqaB-2z67A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 12 ALA A 308
ILE A 137
SER A 142
SER A 148
TYR A 112
 None
 1.19A 3k2hB-2z67A:
2.7		 3k2hB-2z67A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		4 / 6 ILE A 230
LEU A 219
ARG A 268
THR A 292
 None
 0.98A 3wg7A-2z67A:
undetectable
3wg7J-2z67A:
undetectable		 3wg7A-2z67A:
20.74
3wg7J-2z67A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		4 / 6 ILE A 434
LEU A 431
ARG A 385
THR A 387
 None
 1.15A 3wg7A-2z67A:
undetectable
3wg7J-2z67A:
undetectable		 3wg7A-2z67A:
20.74
3wg7J-2z67A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 12 GLY A 248
ALA A 249
ASN A 279
TYR A 328
PHE A 122
 None
PLP  A1001 (-3.4A)
None
None
None
 1.25A 4bupA-2z67A:
undetectable		 4bupA-2z67A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 11 GLN A 253
ASN A 414
SER A 362
TYR A 257
LEU A 219
 None
 1.50A 5jh7B-2z67A:
undetectable		 5jh7B-2z67A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 12 TYR A 112
ILE A 252
PHE A 123
LEU A 281
SER A 319
 None
 1.47A 5l8oB-2z67A:
undetectable		 5l8oB-2z67A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 9 ALA A 271
VAL A 269
ILE A 233
ILE A 230
ASN A 247
 None
None
None
None
PLP  A1001 (-3.3A)
 0.96A 5nunA-2z67A:
undetectable		 5nunA-2z67A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 6 ALA A 172
SER A 138
GLY A 287
ILE A 300
PHE A 296
 None
PLP  A1001 (-3.3A)
None
None
None
 1.42A 6f8cA-2z67A:
undetectable		 6f8cA-2z67A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		5 / 6 SER A 275
GLY A 287
THR A 135
ILE A 300
PHE A 296
 None
 1.43A 6f8cA-2z67A:
undetectable		 6f8cA-2z67A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z67 O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Methanococcus
maripaludis) 		4 / 6 ILE A 230
LEU A 219
ARG A 268
THR A 292
 None
 1.14A 6nmfN-2z67A:
undetectable
6nmfW-2z67A:
undetectable		 6nmfN-2z67A:
20.74
6nmfW-2z67A:
10.23