SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 SER A 202
ASN A 233
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
ILE A 280
 FMN  A 500 (-3.6A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 ( 4.6A)
 0.69A 4kukA-2z6cA:
16.6		 4kukA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		10 / 12 VAL A 200
ASN A 233
CYH A 234
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
ILE A 280
GLN A 297
 None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 ( 4.6A)
FMN  A 500 (-3.6A)
 0.52A 4kukA-2z6cA:
16.6		 4kukA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		5 / 12 VAL A 200
ASN A 233
LEU A 278
ILE A 280
GLN A 297
 None
FMN  A 500 (-3.0A)
FMN  A 500 (-4.3A)
FMN  A 500 ( 4.6A)
FMN  A 500 (-3.6A)
 1.26A 4kukA-2z6cA:
16.6		 4kukA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		6 / 9 LEU A 237
ILE A 250
LEU A 254
ILE A 264
PHE A 293
GLY A 295
 FMN  A 500 (-4.4A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.7A)
None
None
FMN  A 500 (-3.9A)
 0.65A 4kukA-2z6cA:
16.6		 4kukA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 SER A 202
ASN A 233
ARG A 235
GLN A 238
LEU A 254
ASN A 266
LEU A 278
GLN A 297
 FMN  A 500 (-3.6A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.6A)
 0.74A 4kuoA-2z6cA:
16.8		 4kuoA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		10 / 12 VAL A 200
ASN A 233
CYH A 234
ARG A 235
GLN A 238
LEU A 254
ASN A 266
ASN A 276
LEU A 278
GLN A 297
 None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.6A)
 0.62A 4kuoA-2z6cA:
16.8		 4kuoA-2z6cA:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 CYH A 234
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
GLY A 295
GLN A 297
 FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.6A)
 0.73A 4r38A-2z6cA:
17.9		 4r38A-2z6cA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		4 / 8 ASN A 233
LEU A 237
ILE A 264
PHE A 293
 FMN  A 500 (-3.0A)
FMN  A 500 (-4.4A)
None
None
 0.60A 4r38A-2z6cA:
17.9		 4r38A-2z6cA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		9 / 12 ASN A 233
CYH A 234
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
GLY A 295
GLN A 297
 FMN  A 500 (-3.0A)
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.6A)
 0.73A 4r38B-2z6cA:
17.8		 4r38B-2z6cA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 CYH A 234
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
GLY A 295
GLN A 297
 FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.6A)
 0.72A 4r38C-2z6cA:
17.8		 4r38C-2z6cA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 CYH A 234
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
GLY A 295
GLN A 297
 FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.6A)
 0.74A 4r38D-2z6cA:
17.9		 4r38D-2z6cA:
36.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		5 / 12 ALA A 248
ILE A 264
ASN A 266
ASN A 276
LEU A 278
 None
None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
 0.87A 4r3aA-2z6cA:
14.7		 4r3aA-2z6cA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 CYH A 234
ARG A 235
GLN A 238
ILE A 264
ASN A 266
ASN A 276
LEU A 278
GLN A 297
 FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.6A)
 0.68A 4r3aA-2z6cA:
14.7		 4r3aA-2z6cA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6c PHOTOTROPIN-1
(Arabidopsis
thaliana) 		8 / 12 CYH A 234
ARG A 235
ILE A 264
ASN A 266
ASN A 276
LEU A 278
GLY A 295
GLN A 297
 FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.6A)
 0.69A 4r3aB-2z6cA:
14.6		 4r3aB-2z6cA:
17.33