SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 SER A 138
ASN A 169
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLN A 233
 FMN  A 500 (-3.6A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.8A)
 0.67A 4kukA-2z6dA:
19.0		 4kukA-2z6dA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		9 / 12 VAL A 136
ASN A 169
CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLN A 233
 None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.8A)
 0.28A 4kukA-2z6dA:
19.0		 4kukA-2z6dA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 9 LEU A 173
VAL A 183
ILE A 186
PHE A 229
GLY A 231
 FMN  A 500 ( 4.4A)
FMN  A 500 ( 4.4A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.5A)
FMN  A 500 (-3.7A)
 0.27A 4kukA-2z6dA:
19.1		 4kukA-2z6dA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 SER A 138
ASN A 169
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLN A 233
 FMN  A 500 (-3.6A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.8A)
 0.67A 4kuoA-2z6dA:
18.8		 4kuoA-2z6dA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		9 / 12 VAL A 136
ASN A 169
CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLN A 233
 None
FMN  A 500 (-3.0A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.8A)
 0.40A 4kuoA-2z6dA:
18.8		 4kuoA-2z6dA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLY A 231
GLN A 233
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.8A)
 0.48A 4r38A-2z6dA:
19.1		 4r38A-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 GLN A 174
ALA A 184
ASN A 202
ASN A 212
LEU A 214
 FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
 1.10A 4r38A-2z6dA:
19.1		 4r38A-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		4 / 8 ASN A 169
LEU A 173
VAL A 183
PHE A 229
 FMN  A 500 (-3.0A)
FMN  A 500 ( 4.4A)
FMN  A 500 ( 4.4A)
FMN  A 500 ( 4.5A)
 0.68A 4r38A-2z6dA:
19.1		 4r38A-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		9 / 12 ASN A 169
CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLY A 231
GLN A 233
 FMN  A 500 (-3.0A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.8A)
 0.51A 4r38B-2z6dA:
19.1		 4r38B-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 GLN A 174
ALA A 184
ASN A 202
ASN A 212
LEU A 214
 FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
 1.12A 4r38B-2z6dA:
19.1		 4r38B-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLY A 231
GLN A 233
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.8A)
 0.47A 4r38C-2z6dA:
19.1		 4r38C-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 GLN A 174
ALA A 184
ASN A 202
ASN A 212
LEU A 214
 FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
 1.13A 4r38C-2z6dA:
19.1		 4r38C-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		8 / 12 CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLY A 231
GLN A 233
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.8A)
 0.50A 4r38D-2z6dA:
19.1		 4r38D-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 GLN A 174
ALA A 184
ASN A 202
ASN A 212
LEU A 214
 FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
 1.08A 4r38D-2z6dA:
19.1		 4r38D-2z6dA:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		7 / 12 CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLN A 233
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.8A)
 0.32A 4r3aA-2z6dA:
15.2		 4r3aA-2z6dA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		5 / 12 GLN A 174
ALA A 184
ASN A 202
ASN A 212
LEU A 214
 FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
 1.00A 4r3aA-2z6dA:
15.2		 4r3aA-2z6dA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2z6d PHOTOTROPIN-2
(Arabidopsis
thaliana) 		7 / 12 CYH A 170
ARG A 171
ASN A 202
ASN A 212
LEU A 214
GLY A 231
GLN A 233
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.8A)
 0.48A 4r3aB-2z6dA:
14.9		 4r3aB-2z6dA:
16.71