SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1
(Homo
sapiens) 		3 / 3 ASP A 845
THR A 855
GLU A 989
 None
 0.84A 1pj7A-2z6eA:
undetectable		 1pj7A-2z6eA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1
(Homo
sapiens) 		5 / 12 LEU A 810
ILE A 881
ASP A 880
ASN A 873
LEU A 874
 None
 0.92A 2nxeA-2z6eA:
undetectable		 2nxeA-2z6eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1
(Homo
sapiens) 		5 / 12 LEU A 810
ILE A 881
ASP A 880
ASN A 873
LEU A 874
 None
 0.97A 3cjtO-2z6eA:
undetectable		 3cjtO-2z6eA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1
(Homo
sapiens) 		4 / 6 PHE A 979
ASN A 841
ALA A 844
THR A 855
 None
 0.97A 4ejgD-2z6eA:
undetectable		 4ejgD-2z6eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2z6e DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1
(Homo
sapiens) 		4 / 5 PHE A 960
PHE A 973
PHE A 972
VAL A 804
 None
 1.07A 5a1rA-2z6eA:
undetectable		 5a1rA-2z6eA:
22.18