SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 6 LEU A 639
ALA A 655
LEU A 642
THR A 652
 None
 1.13A 1tyrA-2z6gA:
undetectable		 1tyrA-2z6gA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 THR A 296
LEU A 323
ILE A 314
GLY A 319
LEU A 285
 None
 1.00A 2ouzA-2z6gA:
undetectable		 2ouzA-2z6gA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 VAL A 616
GLY A 574
ALA A 575
LEU A 579
 None
 0.94A 2wekB-2z6gA:
undetectable		 2wekB-2z6gA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 6 LEU A 404
ALA A 420
LEU A 407
THR A 417
 None
 1.06A 3cfqA-2z6gA:
undetectable		 3cfqA-2z6gA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 8 ASN A 140
LEU A 147
ALA A 145
SER A 183
 None
 0.90A 3kp6A-2z6gA:
undetectable		 3kp6A-2z6gA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 HIS A 222
VAL A 194
LEU A 217
THR A 216
HIS A 218
 None
 1.45A 3lxeA-2z6gA:
undetectable		 3lxeA-2z6gA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 6 ILE A 464
ALA A 463
THR A 449
ALA A 445
 None
 1.08A 3mdrB-2z6gA:
undetectable		 3mdrB-2z6gA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 9 LEU A 261
SER A 221
ILE A 255
ALA A 254
ALA A 238
 None
 1.22A 3mdtA-2z6gA:
undetectable		 3mdtA-2z6gA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 GLY A 421
PRO A 462
ALA A 463
LEU A 384
TRP A 382
 None
 1.06A 3p2kD-2z6gA:
undetectable		 3p2kD-2z6gA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2z6g B-CATENIN
(Danio
rerio) 		3 / 3 LYS A 334
THR A 338
ILE A 302
 None
 0.85A 4e0fB-2z6gA:
undetectable		 4e0fB-2z6gA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 ILE A 464
ALA A 463
THR A 449
ALA A 445
GLY A 441
 None
 1.10A 4enhA-2z6gA:
undetectable		 4enhA-2z6gA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 6 LEU A 404
ALA A 420
LEU A 407
THR A 417
 None
 1.05A 4i89A-2z6gA:
undetectable		 4i89A-2z6gA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 8 GLY A 319
VAL A 324
ALA A 364
MET A 362
LEU A 387
 None
 1.14A 4l9iB-2z6gA:
undetectable		 4l9iB-2z6gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 ILE A 236
LEU A 217
LEU A 261
ALA A 229
SER A 233
 None
 0.99A 4m11B-2z6gA:
undetectable		 4m11B-2z6gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 ILE A 464
VAL A 450
VAL A 416
ALA A 420
LEU A 467
 None
 1.40A 4m11C-2z6gA:
undetectable		 4m11C-2z6gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 VAL A 493
ILE A 443
LEU A 408
ALA A 463
LEU A 470
 None
 1.12A 4m11C-2z6gA:
undetectable		 4m11C-2z6gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z6g B-CATENIN
(Danio
rerio) 		6 / 12 LEU A 217
ILE A 187
ALA A 196
THR A 156
ALA A 170
VAL A 174
 None
 1.40A 4nkxB-2z6gA:
undetectable		 4nkxB-2z6gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 LEU A 369
LEU A 381
ARG A 385
LEU A 384
 None
 0.75A 4wg0B-2z6gA:
undetectable
4wg0C-2z6gA:
undetectable		 4wg0B-2z6gA:
2.52
4wg0C-2z6gA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 LEU A 579
LEU A 526
ARG A 514
LEU A 512
ILE A 513
 None
 1.10A 4x1gA-2z6gA:
undetectable		 4x1gA-2z6gA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 6 LEU A 404
ALA A 420
LEU A 407
THR A 417
 None
 1.04A 5bojA-2z6gA:
undetectable		 5bojA-2z6gA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 5 GLY A 574
THR A 573
GLY A 442
LEU A 516
 None
 0.92A 5jlcA-2z6gA:
undetectable		 5jlcA-2z6gA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 4 GLN A 202
THR A 200
LEU A 220
LEU A 217
 None
 1.18A 5m5kB-2z6gA:
undetectable		 5m5kB-2z6gA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 ILE A 230
GLY A 226
HIS A 223
SER A 221
VAL A 198
 None
 1.14A 5n0oA-2z6gA:
undetectable		 5n0oA-2z6gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 ILE A 230
GLY A 226
HIS A 223
SER A 221
VAL A 198
 None
 1.13A 5n0oB-2z6gA:
undetectable		 5n0oB-2z6gA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2z6g B-CATENIN
(Danio
rerio) 		5 / 12 THR A 297
ILE A 302
LEU A 243
LEU A 258
LEU A 263
 None
 1.02A 5nfjA-2z6gA:
undetectable		 5nfjA-2z6gA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 8 VAL A 357
GLY A 366
GLN A 363
LEU A 400
 None
 1.08A 5sxqB-2z6gA:
undetectable		 5sxqB-2z6gA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 8 VAL A 357
GLY A 366
GLN A 363
LEU A 400
 None
 1.10A 5syjA-2z6gA:
undetectable		 5syjA-2z6gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 ILE A 255
LEU A 258
ILE A 314
ALA A 275
 None
 0.80A 6b5vA-2z6gA:
undetectable
6b5vC-2z6gA:
undetectable		 6b5vA-2z6gA:
7.39
6b5vC-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 ALA A 271
ILE A 255
LEU A 258
ILE A 314
 None
 0.88A 6b5vA-2z6gA:
undetectable
6b5vB-2z6gA:
undetectable		 6b5vA-2z6gA:
7.39
6b5vB-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 ALA A 275
ILE A 255
LEU A 258
ILE A 314
 None
 0.81A 6b5vA-2z6gA:
undetectable
6b5vB-2z6gA:
undetectable		 6b5vA-2z6gA:
7.39
6b5vB-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 ALA A 304
ILE A 326
LEU A 323
ILE A 255
 None
 0.77A 6b5vA-2z6gA:
undetectable
6b5vB-2z6gA:
undetectable		 6b5vA-2z6gA:
7.39
6b5vB-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 ILE A 255
LEU A 258
ILE A 314
ALA A 275
 None
 0.79A 6b5vC-2z6gA:
undetectable
6b5vD-2z6gA:
undetectable		 6b5vC-2z6gA:
7.39
6b5vD-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6g B-CATENIN
(Danio
rerio) 		4 / 7 ALA A 275
ILE A 255
LEU A 258
ILE A 314
 None
 0.80A 6b5vB-2z6gA:
undetectable
6b5vD-2z6gA:
undetectable		 6b5vB-2z6gA:
7.39
6b5vD-2z6gA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2z6g B-CATENIN
(Danio
rerio) 		4 / 8 LEU A 404
LEU A 369
GLY A 360
ARG A 328
 None
 0.91A 6ce2A-2z6gA:
undetectable		 6ce2A-2z6gA:
8.89