SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 5 THR A 340
THR A 339
GLU A 334
HIS A 369
 None
 1.43A 1d4fB-2z6hA:
undetectable		 1d4fB-2z6hA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		3 / 3 ASN A 380
TRP A 338
GLN A 375
 None
 1.43A 1xoqA-2z6hA:
undetectable		 1xoqA-2z6hA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 THR A 297
LEU A 324
ILE A 315
GLY A 320
LEU A 286
 None
 0.94A 2ouzA-2z6hA:
undetectable		 2ouzA-2z6hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		3 / 3 LEU A 640
PRO A 639
LEU A 643
 None
 0.58A 2po5B-2z6hA:
undetectable		 2po5B-2z6hA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 6 ILE A 465
ALA A 464
THR A 450
ALA A 446
 None
 1.09A 3mdrB-2z6hA:
undetectable		 3mdrB-2z6hA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 11 LEU A 221
SER A 179
ILE A 231
THR A 201
ALA A 197
 None
 1.13A 3mdtB-2z6hA:
undetectable		 3mdtB-2z6hA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 9 PRO A 534
GLY A 531
ALA A 532
ALA A 525
LEU A 580
 None
 1.48A 3ur0C-2z6hA:
1.5		 3ur0C-2z6hA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 6 THR A 574
GLY A 572
ILE A 569
LEU A 536
 None
 1.13A 4ac9C-2z6hA:
undetectable		 4ac9C-2z6hA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 6 THR A 574
GLY A 572
ILE A 569
LEU A 536
 None
 1.11A 4acaC-2z6hA:
undetectable		 4acaC-2z6hA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		3 / 3 TYR A 254
ARG A 212
SER A 250
 None
 1.14A 4dr2I-2z6hA:
undetectable
4dr2J-2z6hA:
undetectable		 4dr2I-2z6hA:
11.03
4dr2J-2z6hA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 11 VAL A 438
LEU A 471
THR A 472
GLU A 445
VAL A 441
 None
 1.14A 4e0fA-2z6hA:
undetectable		 4e0fA-2z6hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 5 VAL A 564
ARG A 565
MET A 566
GLU A 567
 None
 1.45A 4hojA-2z6hA:
undetectable		 4hojA-2z6hA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		3 / 3 TYR A 254
ARG A 212
SER A 250
 None
 0.96A 4khpI-2z6hA:
undetectable
4khpJ-2z6hA:
undetectable		 4khpI-2z6hA:
11.03
4khpJ-2z6hA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 8 GLY A 320
VAL A 325
ALA A 365
MET A 363
LEU A 388
 None
 1.15A 4l9iB-2z6hA:
undetectable		 4l9iB-2z6hA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 GLY A 277
ALA A 276
ASN A 308
SER A 311
ILE A 314
 None
 1.18A 4pb1A-2z6hA:
undetectable		 4pb1A-2z6hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 GLY A 277
ALA A 276
ASN A 308
SER A 311
ILE A 314
 None
 1.18A 4pd9A-2z6hA:
undetectable		 4pd9A-2z6hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 GLY A 278
ALA A 276
ASN A 308
SER A 311
ILE A 314
 None
 1.19A 4pd9A-2z6hA:
undetectable		 4pd9A-2z6hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 6 THR A 298
THR A 339
THR A 330
LEU A 286
 None
 1.09A 4pgfA-2z6hA:
undetectable		 4pgfA-2z6hA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 10 ASN A 431
ASN A 434
VAL A 438
LEU A 402
LEU A 424
 None
 1.18A 4po0A-2z6hA:
2.0		 4po0A-2z6hA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 446
LEU A 408
VAL A 417
ILE A 414
 None
 1.13A 4uw0A-2z6hA:
undetectable		 4uw0A-2z6hA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 11 LEU A 401
LEU A 370
LEU A 382
ARG A 386
LEU A 385
 None
 1.13A 4wg0I-2z6hA:
undetectable
4wg0J-2z6hA:
undetectable
4wg0K-2z6hA:
undetectable		 4wg0I-2z6hA:
2.52
4wg0J-2z6hA:
2.52
4wg0K-2z6hA:
2.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 231
GLY A 227
HIS A 224
SER A 222
VAL A 199
 None
 1.12A 5n0oA-2z6hA:
undetectable		 5n0oA-2z6hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 231
GLY A 227
HIS A 224
SER A 222
VAL A 199
 None
 1.11A 5n0oB-2z6hA:
undetectable		 5n0oB-2z6hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		6 / 12 LEU A 580
ILE A 579
GLY A 575
LEU A 527
LEU A 491
LEU A 517
 None
 1.49A 5nfjA-2z6hA:
undetectable		 5nfjA-2z6hA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ILE A 256
LEU A 259
ILE A 315
ALA A 272
 None
 0.83A 6b5vA-2z6hA:
undetectable
6b5vC-2z6hA:
undetectable		 6b5vA-2z6hA:
8.63
6b5vC-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ILE A 256
LEU A 259
ILE A 315
ALA A 276
 None
 0.84A 6b5vA-2z6hA:
undetectable
6b5vC-2z6hA:
undetectable		 6b5vA-2z6hA:
8.63
6b5vC-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ALA A 272
ILE A 256
LEU A 259
ILE A 315
 None
 0.82A 6b5vA-2z6hA:
undetectable
6b5vB-2z6hA:
undetectable		 6b5vA-2z6hA:
8.63
6b5vB-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ALA A 276
ILE A 256
LEU A 259
ILE A 315
 None
 0.85A 6b5vA-2z6hA:
undetectable
6b5vB-2z6hA:
undetectable		 6b5vA-2z6hA:
8.63
6b5vB-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ALA A 305
ILE A 327
LEU A 324
ILE A 256
 None
 0.74A 6b5vA-2z6hA:
undetectable
6b5vB-2z6hA:
undetectable		 6b5vA-2z6hA:
8.63
6b5vB-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ILE A 256
LEU A 259
ILE A 315
ALA A 272
 None
 0.85A 6b5vC-2z6hA:
undetectable
6b5vD-2z6hA:
undetectable		 6b5vC-2z6hA:
8.63
6b5vD-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ILE A 256
LEU A 259
ILE A 315
ALA A 276
 None
 0.83A 6b5vC-2z6hA:
undetectable
6b5vD-2z6hA:
undetectable		 6b5vC-2z6hA:
8.63
6b5vD-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ALA A 272
ILE A 256
LEU A 259
ILE A 315
 None
 0.83A 6b5vB-2z6hA:
undetectable
6b5vD-2z6hA:
undetectable		 6b5vB-2z6hA:
8.63
6b5vD-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 7 ALA A 276
ILE A 256
LEU A 259
ILE A 315
 None
 0.85A 6b5vB-2z6hA:
undetectable
6b5vD-2z6hA:
undetectable		 6b5vB-2z6hA:
8.63
6b5vD-2z6hA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		5 / 12 GLY A 319
ALA A 323
ASN A 353
SER A 352
VAL A 346
 None
 0.88A 6bqgA-2z6hA:
undetectable		 6bqgA-2z6hA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z6h CATENIN BETA-1
(Homo
sapiens) 		4 / 6 LEU A 263
VAL A 349
MET A 271
GLY A 268
 None
 1.03A 6hd4B-2z6hA:
undetectable		 6hd4B-2z6hA:
8.23