SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 6 THR A 192
GLY A 143
THR A 218
ILE A 145
 FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
None
None
 0.89A 1gtnD-2z6iA:
undetectable
1gtnE-2z6iA:
undetectable		 1gtnD-2z6iA:
15.21
1gtnE-2z6iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 7 THR A 192
GLY A 143
THR A 218
ILE A 145
 FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
None
None
 0.90A 1gtnF-2z6iA:
undetectable
1gtnG-2z6iA:
undetectable		 1gtnF-2z6iA:
15.21
1gtnG-2z6iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 7 THR A 192
GLY A 143
THR A 218
ILE A 145
 FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
None
None
 0.88A 1gtnJ-2z6iA:
undetectable
1gtnK-2z6iA:
undetectable		 1gtnJ-2z6iA:
15.21
1gtnK-2z6iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 8 LEU A   9
ILE A 114
ILE A   5
ILE A 166
 None
 0.83A 2bu8A-2z6iA:
undetectable		 2bu8A-2z6iA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		6 / 12 LEU A  38
GLY A  30
ALA A  29
VAL A  68
ILE A  55
VAL A  91
 None
 1.43A 2f8gB-2z6iA:
undetectable		 2f8gB-2z6iA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 11 VAL A 289
GLY A 287
ILE A 232
THR A 192
THR A 218
 None
None
None
FMN  A 401 (-3.7A)
None
 1.17A 2f9wA-2z6iA:
undetectable
2f9wB-2z6iA:
undetectable		 2f9wA-2z6iA:
20.76
2f9wB-2z6iA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 12 ALA A  31
ALA A 197
ALA A  35
GLY A  39
GLY A  30
 None
 1.10A 2igtA-2z6iA:
undetectable		 2igtA-2z6iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 12 ALA A  31
ALA A 197
ALA A  35
GLY A  39
GLY A  30
 None
 1.11A 2igtB-2z6iA:
undetectable		 2igtB-2z6iA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		6 / 12 ILE A 285
ILE A 171
GLY A 191
ALA A 172
ALA A  24
VAL A  23
 FMN  A 401 ( 4.9A)
None
FMN  A 401 (-3.2A)
None
None
None
 1.23A 2yvlA-2z6iA:
undetectable		 2yvlA-2z6iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		6 / 12 ILE A 285
ILE A 171
GLY A 191
ALA A 172
ALA A  24
VAL A  23
 FMN  A 401 ( 4.9A)
None
FMN  A 401 (-3.2A)
None
None
None
 1.24A 2yvlB-2z6iA:
undetectable		 2yvlB-2z6iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		6 / 12 ILE A 285
ILE A 171
GLY A 191
ALA A 172
ALA A  24
VAL A  23
 FMN  A 401 ( 4.9A)
None
FMN  A 401 (-3.2A)
None
None
None
 1.22A 2yvlC-2z6iA:
undetectable		 2yvlC-2z6iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		6 / 12 LEU A  38
GLY A  30
ALA A  29
VAL A  68
ILE A  55
VAL A  91
 None
 1.48A 3bvbA-2z6iA:
undetectable		 3bvbA-2z6iA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB304_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 4 ARG A 193
VAL A 289
LYS A 291
GLU A 293
 None
 1.22A 3deuB-2z6iA:
0.0		 3deuB-2z6iA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 12 VAL A 157
ALA A 136
LEU A   8
ILE A 114
HIS A 107
 None
 0.86A 3gcsA-2z6iA:
undetectable		 3gcsA-2z6iA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 11 ILE A  55
ILE A 111
VAL A  92
VAL A  89
GLY A  88
 None
 0.97A 3kw4A-2z6iA:
undetectable		 3kw4A-2z6iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 9 ALA A  31
GLY A  39
LEU A 299
LEU A  38
ILE A  15
 None
 1.32A 3wdmA-2z6iA:
undetectable		 3wdmA-2z6iA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 7 ILE A   5
LEU A   9
ALA A 187
VAL A 188
ALA A 133
 None
 1.27A 4g77A-2z6iA:
undetectable		 4g77A-2z6iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 12 GLY A 170
GLY A 138
ARG A 230
ALA A 167
ALA A 172
 FMN  A 401 (-3.6A)
None
None
None
None
 1.16A 4kicA-2z6iA:
undetectable		 4kicA-2z6iA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 4 HIS A 144
ALA A 228
VAL A 229
GLU A 244
 None
 1.26A 4n6pA-2z6iA:
0.0		 4n6pA-2z6iA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 6 MET A 103
ILE A  55
ILE A  41
VAL A  51
 None
 0.99A 4olmA-2z6iA:
undetectable		 4olmA-2z6iA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		3 / 3 ARG A 193
LYS A 291
GLU A 293
 None
 0.60A 5d0yA-2z6iA:
undetectable		 5d0yA-2z6iA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		4 / 7 GLY A 169
ALA A 168
VAL A 157
LEU A 153
 FMN  A 401 (-3.3A)
FMN  A 401 ( 3.9A)
None
None
 0.81A 6dwnB-2z6iA:
undetectable		 6dwnB-2z6iA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2z6i TRANS-2-ENOYL-ACP
REDUCTASE II
(Streptococcus
pneumoniae) 		5 / 9 ILE A  41
ALA A  29
GLY A  39
LEU A  38
GLY A 191
 None
None
None
None
FMN  A 401 (-3.2A)
 1.21A 6nm4B-2z6iA:
undetectable		 6nm4B-2z6iA:
20.45