SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 2z6p UFM1-CONJUGATING
ENZYME 1
(Homo
sapiens) 		5 / 11 HIS A 120
TRP A 125
GLY A 141
TYR A  42
VAL A  10
 None
 1.49A 1axwB-2z6pA:
undetectable		 1axwB-2z6pA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2z6p UFM1-CONJUGATING
ENZYME 1
(Homo
sapiens) 		5 / 12 ILE A  86
ALA A  94
ILE A  97
PHE A  84
LEU A  56
 None
 1.03A 4cd2A-2z6pA:
undetectable		 4cd2A-2z6pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2z6p UFM1-CONJUGATING
ENZYME 1
(Homo
sapiens) 		3 / 3 ARG A 127
THR A   6
ASP A   3
 None
 0.92A 5g5gA-2z6pA:
undetectable
5g5gB-2z6pA:
undetectable		 5g5gA-2z6pA:
20.26
5g5gB-2z6pA:
19.26