SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.14A 1os2D-2z7bA:
undetectable		 1os2D-2z7bA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.16A 1uttA-2z7bA:
undetectable		 1uttA-2z7bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.12A 1utzA-2z7bA:
undetectable		 1utzA-2z7bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.12A 1utzB-2z7bA:
undetectable		 1utzB-2z7bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 TYR A  81
GLN A  56
LEU A  60
ALA A  42
VAL A  90
 None
 1.43A 2g70A-2z7bA:
undetectable		 2g70A-2z7bA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.13A 2hu6A-2z7bA:
undetectable		 2hu6A-2z7bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.08A 2ow9B-2z7bA:
undetectable		 2ow9B-2z7bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.08A 2ozrC-2z7bA:
undetectable		 2ozrC-2z7bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.06A 2ozrD-2z7bA:
undetectable		 2ozrD-2z7bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.12A 2ozrE-2z7bA:
undetectable		 2ozrE-2z7bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		3 / 3 MET A   1
GLU A   8
ASP A 218
 None
 1.06A 3a25A-2z7bA:
undetectable		 3a25A-2z7bA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 5 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.13A 3likA-2z7bA:
undetectable		 3likA-2z7bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.14A 3lilA-2z7bA:
undetectable		 3lilA-2z7bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 5 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.12A 3lkaA-2z7bA:
undetectable		 3lkaA-2z7bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		5 / 12 GLU A  79
TYR A  75
ALA A 149
ASP A 147
VAL A 144
 None
 1.08A 3nvkF-2z7bA:
undetectable
3nvkJ-2z7bA:
undetectable		 3nvkF-2z7bA:
24.62
3nvkJ-2z7bA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		3 / 3 HIS A  92
HIS A  94
HIS A 163
 MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
MN  A 235 (-3.6A)
 0.61A 3qpkB-2z7bA:
undetectable		 3qpkB-2z7bA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 4 HIS A 163
GLU A  73
HIS A  92
HIS A  94
 MN  A 235 (-3.6A)
MN  A 235 (-2.6A)
MN  A 235 (-3.4A)
MN  A 235 (-3.8A)
 1.12A 5n5jA-2z7bA:
undetectable		 5n5jA-2z7bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		5 / 10 HIS A  94
ILE A  21
GLY A  26
VAL A 166
ALA A 179
 MN  A 235 (-3.8A)
None
None
None
None
 0.76A 5o96C-2z7bA:
undetectable
5o96D-2z7bA:
undetectable		 5o96C-2z7bA:
19.31
5o96D-2z7bA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2z7b MLR6791 PROTEIN
(Mesorhizobium
japonicum) 		4 / 6 GLN A  88
VAL A 172
ALA A  12
THR A  13
 None
 1.04A 6cduB-2z7bA:
undetectable
6cduC-2z7bA:
undetectable		 6cduB-2z7bA:
20.00
6cduC-2z7bA:
20.00