SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 2z7e NIFU-LIKE PROTEIN
(Aquifex
aeolicus) 		5 / 11 ILE A  53
ILE A 135
PRO A 136
ILE A  82
THR A  74
 None
 0.99A 1dyrA-2z7eA:
undetectable		 1dyrA-2z7eA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2z7e NIFU-LIKE PROTEIN
(Aquifex
aeolicus) 		3 / 3 GLU A   7
LEU A  10
ASP A  11
 None
 0.38A 3ko0A-2z7eA:
undetectable		 3ko0A-2z7eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2z7e NIFU-LIKE PROTEIN
(Aquifex
aeolicus) 		3 / 3 GLU A   7
LEU A  10
ASP A  11
 None
 0.24A 3ko0T-2z7eA:
undetectable		 3ko0T-2z7eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 2z7e NIFU-LIKE PROTEIN
(Aquifex
aeolicus) 		5 / 11 ASP A  51
VAL A  46
VAL A 117
VAL A  56
ILE A  53
 None
 1.04A 3oxvD-2z7eA:
undetectable		 3oxvD-2z7eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 2z7e NIFU-LIKE PROTEIN
(Aquifex
aeolicus) 		5 / 10 ASP A  51
VAL A  46
VAL A 117
VAL A  56
ILE A  53
 None
 1.00A 3oxwD-2z7eA:
undetectable		 3oxwD-2z7eA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2z7e NIFU-LIKE PROTEIN
(Aquifex
aeolicus) 		5 / 9 ALA A  85
ILE A  53
VAL A  56
ALA A 118
ILE A  44
 None
 0.92A 4lbgB-2z7eA:
undetectable		 4lbgB-2z7eA:
21.19