SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
VAL A 125
ASN A 192
LEU A 194
THR A 204
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
STU  A   1 ( 3.8A)
 0.50A 1fmoE-2z7rA:
31.9		 1fmoE-2z7rA:
34.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 11 LEU A 256
ALA A 312
ALA A 172
VAL A 164
LEU A 251
 None
 1.35A 1hbpA-2z7rA:
undetectable		 1hbpA-2z7rA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
VAL A  76
ALA A  92
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.59A 1iepA-2z7rA:
21.4		 1iepA-2z7rA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
VAL A  76
ALA A  92
VAL A 125
PHE A 143
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.6A)
 0.51A 1opjA-2z7rA:
21.2		 1opjA-2z7rA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 5 LEU A 195
GLY A 199
HIS A 200
ILE A 201
 None
 0.88A 1xf1A-2z7rA:
undetectable		 1xf1A-2z7rA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 9 LEU A  68
VAL A  76
LYS A  94
LEU A 127
LEU A 139
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
None
 0.54A 1xkkA-2z7rA:
22.5		 1xkkA-2z7rA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A  68
ALA A  92
LEU A 141
ASP A 148
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.43A 1yi4A-2z7rA:
27.1		 1yi4A-2z7rA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 VAL A  76
LYS A  94
VAL A 125
ASP A 148
THR A 151
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-2.8A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.77A 2eufB-2z7rA:
24.4		 2eufB-2z7rA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A 189
ASN A 192
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
STU  A   1 ( 3.8A)
 0.70A 2fumB-2z7rA:
20.3		 2fumB-2z7rA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
GLY A  69
GLY A  71
VAL A  76
ALA A  92
LYS A 189
ASN A 192
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.3A)
 0.80A 2fumD-2z7rA:
25.4		 2fumD-2z7rA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 VAL A  76
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.43A 2hyyC-2z7rA:
21.9		 2hyyC-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 9 LEU A  68
VAL A  76
ALA A  92
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.87A 2xp2A-2z7rA:
8.2		 2xp2A-2z7rA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  68
ALA A  92
LYS A  94
VAL A 125
LEU A 141
GLY A 147
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
 0.85A 3aoxA-2z7rA:
21.3		 3aoxA-2z7rA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  68
ALA A  92
VAL A 125
LEU A 141
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.87A 3aoxA-2z7rA:
21.3		 3aoxA-2z7rA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 VAL A  76
ALA A  92
LEU A 127
GLY A 147
LEU A 194
THR A 204
PHE A 206
 None
STU  A   1 (-3.3A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
None
 0.81A 3bbtB-2z7rA:
21.9		 3bbtB-2z7rA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 VAL A  76
ALA A  92
LEU A 139
GLY A 147
LEU A 194
THR A 204
PHE A 206
 None
STU  A   1 (-3.3A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
None
 0.77A 3bbtD-2z7rA:
23.0		 3bbtD-2z7rA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 VAL A  76
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
THR A 204
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.84A 3bbtD-2z7rA:
23.0		 3bbtD-2z7rA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  68
GLY A  69
ALA A  92
LYS A  94
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.65A 3c7qA-2z7rA:
21.2		 3c7qA-2z7rA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A  68
VAL A  76
LYS A  94
PHE A 143
VAL A 124
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
None
 0.83A 3cs9A-2z7rA:
21.8		 3cs9A-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A  68
VAL A  76
LYS A  94
VAL A 125
PHE A 143
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
 0.48A 3cs9A-2z7rA:
21.8		 3cs9A-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 9 LEU A  68
VAL A  76
LYS A  94
VAL A 125
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
 0.59A 3cs9B-2z7rA:
22.1		 3cs9B-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 6 LEU A  68
VAL A  76
LYS A  94
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
 0.58A 3cs9D-2z7rA:
20.7		 3cs9D-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		10 / 12 LEU A  68
GLY A  69
GLY A  71
GLY A  74
VAL A  76
ALA A  92
LYS A  94
ASN A 192
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.69A 3eygA-2z7rA:
13.6		 3eygA-2z7rA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  68
GLY A  69
GLY A  71
GLY A  74
VAL A  76
ALA A  92
LYS A  94
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.84A 3fupA-2z7rA:
22.6		 3fupA-2z7rA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 144
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.0A)
STU  A   1 (-4.6A)
 0.47A 3fupB-2z7rA:
22.5		 3fupB-2z7rA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
VAL A 125
LEU A 144
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.0A)
 0.46A 3fupB-2z7rA:
22.5		 3fupB-2z7rA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 11 LEU A  68
VAL A  76
ALA A  92
VAL A 125
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.54A 3g0eA-2z7rA:
20.7		 3g0eA-2z7rA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 11 LEU A  68
VAL A  76
ALA A  92
GLY A 147
ASP A 148
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.31A 3g0fA-2z7rA:
21.6		 3g0fA-2z7rA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 4 ASP A  86
GLY A  88
LYS A  81
GLU A  63
 None
 0.92A 3hznD-2z7rA:
undetectable		 3hznD-2z7rA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
VAL A 125
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.90A 3lxkA-2z7rA:
22.5		 3lxkA-2z7rA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
GLY A  69
GLY A  71
VAL A  76
ALA A  92
LYS A  94
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
 0.51A 3lxnA-2z7rA:
22.6		 3lxnA-2z7rA:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
VAL A  76
ALA A  92
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.54A 3ms9B-2z7rA:
21.4		 3ms9B-2z7rA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
VAL A  76
ALA A  92
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.59A 3mssB-2z7rA:
21.7		 3mssB-2z7rA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 9 ALA A  92
VAL A 125
PHE A 143
ASP A 148
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.86A 3ti1A-2z7rA:
25.6		 3ti1A-2z7rA:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
ALA A  92
LYS A  94
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.85A 3ue4A-2z7rA:
23.2		 3ue4A-2z7rA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.81A 3ue4B-2z7rA:
22.9		 3ue4B-2z7rA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.87A 3ug2A-2z7rA:
21.4		 3ug2A-2z7rA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
PHE A 143
GLY A 147
LEU A 178
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
None
 0.47A 3wzeA-2z7rA:
21.6		 3wzeA-2z7rA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 ALA A  92
GLY A 147
ASP A 148
THR A 151
LEU A 194
ASP A 205
 STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.77A 3zbfA-2z7rA:
19.4		 3zbfA-2z7rA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
ALA A  92
GLY A 147
ASP A 148
THR A 151
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
None
STU  A   1 ( 3.8A)
 0.96A 3zbfA-2z7rA:
19.4		 3zbfA-2z7rA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.45A 4ag8A-2z7rA:
21.7		 4ag8A-2z7rA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.44A 4agcA-2z7rA:
21.3		 4agcA-2z7rA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 11 LEU A  68
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.47A 4agdA-2z7rA:
16.1		 4agdA-2z7rA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 9 LEU A  68
VAL A  76
ALA A  92
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.90A 4anqA-2z7rA:
21.5		 4anqA-2z7rA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
PHE A 143
GLY A 147
LEU A 178
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
None
 0.42A 4asdA-2z7rA:
21.5		 4asdA-2z7rA:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 11 LEU A  68
GLY A  69
GLY A  71
VAL A  76
ALA A  92
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.85A 4ckiA-2z7rA:
23.3		 4ckiA-2z7rA:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
GLY A 147
LEU A 194
THR A 204
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.77A 4hjoA-2z7rA:
22.4		 4hjoA-2z7rA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
GLY A 147
THR A 204
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.6A)
STU  A   1 ( 3.8A)
 0.93A 4hjoA-2z7rA:
22.4		 4hjoA-2z7rA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
GLY A 147
LEU A 194
THR A 204
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
STU  A   1 ( 3.8A)
 0.78A 4i22A-2z7rA:
17.4		 4i22A-2z7rA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
THR A 204
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.76A 4i22A-2z7rA:
17.4		 4i22A-2z7rA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 VAL A  76
ALA A  92
ASP A 148
ASP A 187
LYS A 189
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
None
None
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.80A 4i41A-2z7rA:
26.7		 4i41A-2z7rA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 11 ALA A  92
LYS A  94
LEU A 141
ASP A 148
GLU A 191
LEU A 194
ASP A 205
 STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 1.02A 4iaaA-2z7rA:
26.5		 4iaaA-2z7rA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 11 VAL A  76
ALA A  92
LYS A  94
LEU A 141
ASP A 148
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.61A 4iaaA-2z7rA:
26.5		 4iaaA-2z7rA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 GLY A  69
VAL A  76
ALA A  92
LEU A 127
LEU A 139
GLY A 147
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.53A 4ifgA-2z7rA:
17.8		 4ifgA-2z7rA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 127
LEU A 139
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
None
 0.46A 4ifgA-2z7rA:
17.8		 4ifgA-2z7rA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 10 ALA A  92
VAL A 125
PHE A 143
LEU A 144
GLY A 147
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.0A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.53A 4ks8A-2z7rA:
26.9		 4ks8A-2z7rA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 7 VAL A  76
ALA A  92
ASP A 148
LEU A 194
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.65A 4l9iA-2z7rA:
11.7		 4l9iA-2z7rA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 8 GLY A  71
VAL A  76
ALA A  92
ASP A 148
LEU A 194
 STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.89A 4l9iB-2z7rA:
28.4		 4l9iB-2z7rA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 8 VAL A  76
ALA A  92
LYS A  94
ASP A 148
LEU A 194
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
 0.78A 4l9iB-2z7rA:
28.4		 4l9iB-2z7rA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		10 / 12 LEU A  68
GLY A  71
VAL A  76
ALA A  92
LYS A  94
LEU A 141
GLY A 147
ASP A 148
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.75A 4mkcA-2z7rA:
22.1		 4mkcA-2z7rA:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 11 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
ASN A 192
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.3A)
STU  A   1 ( 3.8A)
 0.88A 4o0sA-2z7rA:
29.0		 4o0sA-2z7rA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 11 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
ASN A 192
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 0.66A 4o0sA-2z7rA:
29.0		 4o0sA-2z7rA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 6 VAL A  76
ALA A  92
LYS A  94
LEU A 194
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
 0.70A 4o0uA-2z7rA:
23.8		 4o0uA-2z7rA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 6 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
 0.30A 4o0wA-2z7rA:
28.9		 4o0wA-2z7rA:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 8 GLY A  71
VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
 STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 0.95A 4ogrA-2z7rA:
24.3		 4ogrA-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 8 VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.71A 4ogrA-2z7rA:
24.3		 4ogrA-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 7 ALA A  92
ASP A 148
ASN A 192
LEU A 194
ASP A 205
 STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.62A 4ogrE-2z7rA:
23.5		 4ogrE-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 7 GLY A  69
ALA A  92
ASP A 148
ASN A 192
LEU A 194
 STU  A   1 (-3.3A)
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 0.93A 4ogrE-2z7rA:
23.5		 4ogrE-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 9 GLY A  71
VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
 STU  A   1 ( 4.1A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
 1.00A 4ogrI-2z7rA:
24.3		 4ogrI-2z7rA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 9 VAL A  76
ALA A  92
ASP A 148
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
STU  A   1 (-3.8A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.75A 4ogrI-2z7rA:
24.3		 4ogrI-2z7rA:
26.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  68
GLY A  69
GLY A  71
GLY A  74
VAL A  76
ALA A  92
VAL A 125
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 4.1A)
None
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
 0.65A 4otiA-2z7rA:
26.3		 4otiA-2z7rA:
37.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
LYS A  94
VAL A 125
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.94A 4otwA-2z7rA:
22.5		 4otwA-2z7rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		9 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
PHE A 143
GLY A 147
ASN A 192
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.46A 4twpA-2z7rA:
22.6		 4twpA-2z7rA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  68
VAL A  76
ALA A  92
PHE A 143
GLY A 147
ASN A 192
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.48A 4twpB-2z7rA:
22.5		 4twpB-2z7rA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
THR A 204
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.80A 4wkqA-2z7rA:
21.9		 4wkqA-2z7rA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.82A 4xeyA-2z7rA:
22.6		 4xeyA-2z7rA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 GLY A 174
ASP A 244
ILE A 193
LEU A 171
LEU A 203
 None
 0.97A 4xj7A-2z7rA:
undetectable
4xj7B-2z7rA:
undetectable		 4xj7A-2z7rA:
22.19
4xj7B-2z7rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A 171
LEU A 203
GLY A 174
ASP A 244
ILE A 193
 None
 0.98A 4xj7C-2z7rA:
undetectable
4xj7D-2z7rA:
undetectable		 4xj7C-2z7rA:
22.19
4xj7D-2z7rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 11 ASP A 118
HIS A 121
VAL A 119
VAL A 124
LEU A 178
 None
 1.41A 4yhaC-2z7rA:
undetectable		 4yhaC-2z7rA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A 127
THR A 100
LEU A 101
LEU A 137
LEU A 139
 None
 0.94A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A 137
LEU A 139
LEU A 127
THR A 100
LEU A 101
 None
 0.99A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A 139
LEU A 127
THR A 100
LEU A 101
LEU A 137
 None
 1.01A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 THR A 100
LEU A 101
LEU A 137
LEU A 139
LEU A 127
 None
 1.00A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 THR A 100
LEU A 101
LEU A 137
LEU A 139
LEU A 127
 None
 1.02A 4z91A-2z7rA:
1.9
4z91B-2z7rA:
1.7
4z91C-2z7rA:
undetectable
4z91D-2z7rA:
1.8
4z91E-2z7rA:
1.3		 4z91A-2z7rA:
22.63
4z91B-2z7rA:
22.63
4z91C-2z7rA:
22.63
4z91D-2z7rA:
22.63
4z91E-2z7rA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 9 LEU A  68
VAL A  76
ALA A  92
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.83A 5aaaA-2z7rA:
21.8		 5aaaA-2z7rA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		8 / 10 LEU A  68
VAL A  76
ALA A  92
LYS A  94
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.84A 5aabA-2z7rA:
21.6		 5aabA-2z7rA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 10 LEU A  68
VAL A  76
ALA A  92
LEU A 141
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.93A 5aacA-2z7rA:
21.5		 5aacA-2z7rA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 10 LEU A  68
VAL A  76
ALA A  92
LYS A  94
LEU A 141
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.77A 5aacA-2z7rA:
21.5		 5aacA-2z7rA:
23.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
ALA A  92
LYS A  94
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.81A 5ajqA-2z7rA:
25.1		 5ajqA-2z7rA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
ALA A  92
PHE A 143
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.65A 5ajqA-2z7rA:
25.1		 5ajqA-2z7rA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
GLY A  69
ALA A  92
PHE A 143
GLY A 147
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.88A 5ajqA-2z7rA:
25.1		 5ajqA-2z7rA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 5 TYR A 228
TRP A 246
LEU A 168
LEU A 153
 None
 1.22A 5eshA-2z7rA:
undetectable		 5eshA-2z7rA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 6 PRO A 340
GLU A 161
ALA A 169
LEU A 329
 None
 1.04A 5igiA-2z7rA:
7.3		 5igiA-2z7rA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 GLY A  69
VAL A  76
ALA A  92
VAL A 125
ASP A 148
THR A 151
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
 0.63A 5l2iA-2z7rA:
8.7		 5l2iA-2z7rA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 VAL A  76
ALA A  92
VAL A 125
ASP A 148
THR A 151
LEU A 194
ASP A 205
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.74A 5l2iA-2z7rA:
8.7		 5l2iA-2z7rA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 GLY A  69
VAL A  76
ALA A  92
VAL A 125
ASP A 148
THR A 151
LEU A 194
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.6A)
 0.87A 5l2tA-2z7rA:
8.7		 5l2tA-2z7rA:
29.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 11 LEU A  68
GLY A  69
VAL A  76
ALA A  92
VAL A 125
LEU A 141
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 ( 4.6A)
STU  A   1 (-4.6A)
 0.53A 5lvnA-2z7rA:
31.6		 5lvnA-2z7rA:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A  68
VAL A  76
LYS A  94
PHE A 143
GLY A 147
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
 0.61A 5mo4A-2z7rA:
16.5		 5mo4A-2z7rA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 10 LEU A  68
VAL A  76
ALA A  92
VAL A 125
LEU A 194
THR A 204
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.52A 5n3hA-2z7rA:
29.7		 5n3hA-2z7rA:
34.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  78
ALA A  92
VAL A 125
PHE A 143
GLY A 146
LEU A 194
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
None
STU  A   1 (-4.6A)
 0.92A 5te0A-2z7rA:
24.1		 5te0A-2z7rA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  78
ALA A  92
VAL A 125
PHE A 143
GLY A 147
LEU A 194
 None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
 0.37A 5te0A-2z7rA:
24.1		 5te0A-2z7rA:
28.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 144
TYR A 330
VAL A 119
ASP A 205
PHE A 206
 STU  A   1 (-4.0A)
None
None
STU  A   1 ( 3.8A)
None
 1.40A 5vlmC-2z7rA:
1.5		 5vlmC-2z7rA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 9 LEU A  68
ALA A  92
GLY A 147
THR A 151
THR A 204
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
None
STU  A   1 (-3.6A)
 0.87A 5w5vA-2z7rA:
5.2		 5w5vA-2z7rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 9 LEU A  68
ALA A  92
VAL A 125
GLY A 147
THR A 204
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-3.6A)
 0.87A 5w5vA-2z7rA:
5.2		 5w5vA-2z7rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		7 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.54A 5y80A-2z7rA:
23.3		 5y80A-2z7rA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		4 / 8 LEU A  68
VAL A  76
LYS A  94
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 ( 3.8A)
 0.76A 5y9mA-2z7rA:
21.9		 5y9mA-2z7rA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 139
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
 0.62A 5yu9A-2z7rA:
22.2		 5yu9A-2z7rA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 GLY A  69
VAL A  76
ALA A  92
LEU A 139
LEU A 194
THR A 204
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.86A 5yu9B-2z7rA:
22.4		 5yu9B-2z7rA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		5 / 12 VAL A  76
ALA A  92
LYS A  94
LEU A 139
THR A 204
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-3.6A)
 0.69A 5yu9C-2z7rA:
21.8		 5yu9C-2z7rA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens) 		6 / 12 LEU A  68
VAL A  76
ALA A  92
LYS A  94
VAL A 125
PHE A 143
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.6A)
 0.56A 6hd6B-2z7rA:
21.0		 6hd6B-2z7rA:
13.87