SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ALA A  53
LEU A  78
SER A  98
THR A  51
 None
 0.94A 1dvxA-2z7xA:
undetectable		 1dvxA-2z7xA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 TRP A 434
PRO A 435
LEU A 415
LEU A 392
ALA A 381
 None
 1.46A 1hk3A-2z7xA:
undetectable		 1hk3A-2z7xA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU B 237
LEU B 240
ILE B 254
LEU B 192
VAL B 213
 None
 1.11A 1hrkA-2z7xB:
undetectable		 1hrkA-2z7xB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU B 387
SER B 432
ASN B 433
GLN B 380
 None
NAG  A 833 ( 3.9A)
None
NAG  A 831 ( 3.8A)
 1.15A 1ig3A-2z7xB:
undetectable
1ig3B-2z7xB:
undetectable		 1ig3A-2z7xB:
20.08
1ig3B-2z7xB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 GLN B 380
LEU B 387
SER B 431
ASN B 433
 NAG  A 831 ( 3.8A)
None
NAG  A 831 (-3.6A)
None
 1.10A 1ig3A-2z7xB:
undetectable
1ig3B-2z7xB:
undetectable		 1ig3A-2z7xB:
20.08
1ig3B-2z7xB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 GLN B 380
LEU B 387
SER B 432
ASN B 433
 NAG  A 831 ( 3.8A)
None
NAG  A 833 ( 3.9A)
None
 1.01A 1ig3A-2z7xB:
undetectable
1ig3B-2z7xB:
undetectable		 1ig3A-2z7xB:
20.08
1ig3B-2z7xB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE B 261
ILE B 322
VAL B 273
LEU B 251
ILE B 264
 None
 1.31A 1kqwA-2z7xB:
undetectable		 1kqwA-2z7xB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 LEU A 367
VAL A 343
ILE A 341
LEU A 412
LEU A 389
 None
 1.19A 1mrqA-2z7xA:
undetectable		 1mrqA-2z7xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 SER A  85
THR A  84
ASN A  62
LEU A  43
 None
 1.36A 1mxdA-2z7xA:
undetectable		 1mxdA-2z7xA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 SER B 122
SER B 147
PHE B 143
VAL B 195
 None
 1.03A 1oipA-2z7xB:
1.4		 1oipA-2z7xB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 525
PHE A 519
SER A 507
ILE A 506
LEU A 492
 None
 1.17A 1rx3A-2z7xA:
undetectable		 1rx3A-2z7xA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 LEU B  71
ASN B 103
ILE B  81
LEU B  60
PHE B  89
 None
 1.40A 1tw4A-2z7xB:
undetectable		 1tw4A-2z7xB:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 1.00A 1v54A-2z7xB:
undetectable
1v54J-2z7xB:
undetectable		 1v54A-2z7xB:
23.01
1v54J-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.97A 1v54N-2z7xB:
undetectable
1v54W-2z7xB:
undetectable		 1v54N-2z7xB:
23.01
1v54W-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ILE B 447
LEU B 450
THR B 492
LEU B 491
 None
 0.93A 1v55A-2z7xB:
undetectable
1v55J-2z7xB:
undetectable		 1v55A-2z7xB:
23.01
1v55J-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 LEU B 129
LEU B 121
SER B 122
LEU B 168
 None
 1.11A 1ya3A-2z7xB:
undetectable		 1ya3A-2z7xB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PHE A 162
LEU A 139
LEU A 154
LEU A 179
 None
 0.99A 2bfpC-2z7xA:
undetectable		 2bfpC-2z7xA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		6 / 12 LEU B 400
LEU B 425
LEU B 428
ILE B 405
ILE B 390
ALA B 391
 None
 1.46A 2bxqA-2z7xB:
undetectable		 2bxqA-2z7xB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 ILE B  52
SER B  32
ASP B  30
LEU B  50
 None
NAG  A 801 (-2.9A)
NAG  A 801 ( 4.6A)
None
 0.91A 2cdqA-2z7xB:
undetectable		 2cdqA-2z7xB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 SER B 431
SER B 432
SER B 406
ASN B 429
 NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
 1.06A 2cmlA-2z7xB:
undetectable		 2cmlA-2z7xB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
 0.96A 2cmlA-2z7xA:
undetectable		 2cmlA-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 SER B 431
SER B 432
SER B 406
ASN B 429
 NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
 0.99A 2cmlB-2z7xB:
undetectable		 2cmlB-2z7xB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
 0.86A 2cmlB-2z7xA:
undetectable		 2cmlB-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 SER B 431
SER B 432
SER B 406
ASN B 429
 NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
 1.03A 2cmlC-2z7xB:
undetectable		 2cmlC-2z7xB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
 0.94A 2cmlC-2z7xA:
undetectable		 2cmlC-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 SER B 431
SER B 432
SER B 406
ASN B 429
 NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
 1.12A 2cmlD-2z7xB:
undetectable		 2cmlD-2z7xB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
 1.02A 2cmlD-2z7xA:
undetectable		 2cmlD-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 1.01A 2dyrA-2z7xB:
undetectable
2dyrJ-2z7xB:
undetectable		 2dyrA-2z7xB:
23.01
2dyrJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.98A 2dyrN-2z7xB:
undetectable
2dyrW-2z7xB:
undetectable		 2dyrN-2z7xB:
23.01
2dyrW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.99A 2dysA-2z7xB:
undetectable
2dysJ-2z7xB:
undetectable		 2dysA-2z7xB:
23.01
2dysJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.94A 2dysN-2z7xB:
undetectable
2dysW-2z7xB:
undetectable		 2dysN-2z7xB:
23.01
2dysW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 1.02A 2eijA-2z7xB:
undetectable
2eijJ-2z7xB:
undetectable		 2eijA-2z7xB:
23.01
2eijJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.97A 2eikA-2z7xB:
undetectable
2eikJ-2z7xB:
undetectable		 2eikA-2z7xB:
23.01
2eikJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.94A 2eikN-2z7xB:
undetectable
2eikW-2z7xB:
undetectable		 2eikN-2z7xB:
23.01
2eikW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.96A 2eilA-2z7xB:
undetectable
2eilJ-2z7xB:
undetectable		 2eilA-2z7xB:
23.01
2eilJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 1.01A 2einN-2z7xA:
undetectable
2einW-2z7xA:
undetectable		 2einN-2z7xA:
20.40
2einW-2z7xA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 LEU A 522
LEU A 525
ILE A 528
PHE A 519
LEU A 492
 None
 1.25A 2f78B-2z7xA:
undetectable		 2f78B-2z7xA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 LEU A 522
LEU A 525
ILE A 528
PHE A 519
LEU A 492
 None
 1.20A 2f7aB-2z7xA:
undetectable		 2f7aB-2z7xA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE A 256
ILE A 261
LEU A 289
LEU A 273
PHE A 295
 None
 1.01A 2jn3A-2z7xA:
undetectable		 2jn3A-2z7xA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU B 237
LEU B 240
ILE B 254
LEU B 192
VAL B 213
 None
 1.16A 2po5A-2z7xB:
undetectable		 2po5A-2z7xB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU B 237
LEU B 240
ILE B 254
LEU B 192
VAL B 213
 None
 1.10A 2po7A-2z7xB:
undetectable		 2po7A-2z7xB:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU B 425
LEU B 428
GLN B 396
LEU B 384
VAL B 410
 None
 1.39A 2qd4A-2z7xB:
undetectable		 2qd4A-2z7xB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 PRO B 509
ILE B 511
ARG B 510
ASP B 505
 None
 1.22A 2rhmB-2z7xB:
undetectable		 2rhmB-2z7xB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 PRO B 509
ILE B 511
ARG B 510
ASP B 505
 None
 1.12A 2rhmD-2z7xB:
undetectable		 2rhmD-2z7xB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU A 498
VAL A 464
ILE A 455
PHE A 472
 None
 0.92A 2weyB-2z7xA:
undetectable		 2weyB-2z7xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 PHE B 488
LEU B 480
VAL B 475
VAL B 464
 None
 1.03A 2zuhA-2z7xB:
undetectable		 2zuhA-2z7xB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.97A 2zxwA-2z7xB:
undetectable
2zxwJ-2z7xB:
undetectable		 2zxwA-2z7xB:
23.01
2zxwJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		6 / 12 PRO B 130
LEU B 129
ILE B 164
THR B 212
VAL B 210
LEU B 192
 None
 1.34A 3a51B-2z7xB:
undetectable		 3a51B-2z7xB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU B 129
ILE B 164
THR B 212
VAL B 210
LEU B 192
 None
 1.18A 3a51C-2z7xB:
undetectable		 3a51C-2z7xB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 1.04A 3ablA-2z7xB:
undetectable
3ablJ-2z7xB:
undetectable		 3ablA-2z7xB:
23.01
3ablJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 1.03A 3abmA-2z7xB:
undetectable
3abmJ-2z7xB:
undetectable		 3abmA-2z7xB:
23.01
3abmJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.91A 3abmN-2z7xB:
undetectable
3abmW-2z7xB:
undetectable		 3abmN-2z7xB:
23.01
3abmW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.94A 3ag3N-2z7xB:
undetectable
3ag3W-2z7xB:
undetectable		 3ag3N-2z7xB:
23.01
3ag3W-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.97A 3asnA-2z7xB:
undetectable
3asnJ-2z7xB:
undetectable		 3asnA-2z7xB:
23.01
3asnJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.95A 3asnN-2z7xB:
undetectable
3asnW-2z7xB:
undetectable		 3asnN-2z7xB:
23.01
3asnW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.98A 3asoA-2z7xB:
undetectable
3asoJ-2z7xB:
undetectable		 3asoA-2z7xB:
23.01
3asoJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 11 VAL B 449
LEU B 450
ILE B 405
SER B 406
SER B 432
 None
None
None
NAG  A 831 (-3.0A)
NAG  A 833 ( 3.9A)
 1.20A 3bjwH-2z7xB:
undetectable		 3bjwH-2z7xB:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 VAL B 156
LEU B 129
ILE B  86
LEU B 121
LEU B 100
 None
 0.97A 3cjtC-2z7xB:
undetectable		 3cjtC-2z7xB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 522
LEU A 492
VAL A 514
ILE A 528
LEU A 530
 None
 1.13A 3datA-2z7xA:
undetectable		 3datA-2z7xA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 TYR A 109
ASP A 160
HIS A 206
 None
 0.65A 3e23A-2z7xA:
undetectable		 3e23A-2z7xA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 ALA A 495
LEU A 501
ILE A 528
LEU A 530
PHE A 519
 None
 1.25A 3fl9D-2z7xA:
undetectable		 3fl9D-2z7xA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 MET A 428
LEU A 402
GLY A 406
MET A 438
LEU A 459
 None
 1.21A 3h52A-2z7xA:
undetectable		 3h52A-2z7xA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 10 LEU A 522
LEU A 492
VAL A 514
ILE A 528
LEU A 530
 None
 1.17A 3jw5B-2z7xA:
undetectable		 3jw5B-2z7xA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 ARG A 447
THR A 452
THR A 405
 None
 0.51A 3k2hB-2z7xA:
undetectable		 3k2hB-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ASN A 110
LEU A  83
ASP A 106
SER A  85
 None
 1.39A 3lslA-2z7xA:
undetectable
3lslD-2z7xA:
undetectable		 3lslA-2z7xA:
19.20
3lslD-2z7xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.99A 3p50A-2z7xA:
undetectable		 3p50A-2z7xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 SER A 108
TYR A 136
LEU A 112
ILE A  67
PHE A 120
 None
 1.39A 3qt0A-2z7xA:
undetectable		 3qt0A-2z7xA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 ILE B 278
SER B 279
THR B 250
SER B 219
GLU B 217
 None
 1.50A 3r75A-2z7xB:
undetectable		 3r75A-2z7xB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 PRO B  40
LEU B  68
LEU B  71
ILE B  52
 None
 0.96A 3u5jA-2z7xB:
undetectable		 3u5jA-2z7xB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 PRO B  40
LEU B  68
LEU B  71
ILE B  52
 None
 0.91A 3u5kA-2z7xB:
undetectable		 3u5kA-2z7xB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 SER B 507
ASP B 485
ASP B 489
ILE B 487
 None
 1.25A 3uj7B-2z7xB:
undetectable		 3uj7B-2z7xB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 SER A 538
ASP A 516
ASP A 520
ILE A 518
 None
 1.36A 3uj7B-2z7xA:
undetectable		 3uj7B-2z7xA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 ILE B 262
LEU B 265
TYR B 294
MET B 326
 None
 1.19A 3wg7A-2z7xB:
undetectable
3wg7J-2z7xB:
undetectable		 3wg7A-2z7xB:
23.01
3wg7J-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU B  95
LEU B  71
LEU B  50
ILE B  76
ILE B  65
 None
 1.14A 4a7aB-2z7xB:
undetectable		 4a7aB-2z7xB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 THR B 332
ASN B 382
LEU B 360
PHE B 331
 None
 1.34A 4awuA-2z7xB:
undetectable		 4awuA-2z7xB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 LEU B 425
ILE B 405
ALA B 391
MET B 430
 None
 0.97A 4dc3B-2z7xB:
undetectable		 4dc3B-2z7xB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 VAL B 273
PHE B 276
PHE B 261
LEU B 251
THR B 297
 None
 1.18A 4eckB-2z7xB:
undetectable		 4eckB-2z7xB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 MET B 397
LEU B 400
PRO B 344
SER B 348
 None
 1.23A 4kmmB-2z7xB:
undetectable		 4kmmB-2z7xB:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 6 THR A 411
LEU A 354
ASN A 379
LEU A 350
 None
 1.13A 4nc3A-2z7xA:
undetectable		 4nc3A-2z7xA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 LEU A 282
THR A 232
VAL A 269
PHE A 217
LEU A 213
 None
 1.37A 4wnvA-2z7xA:
undetectable		 4wnvA-2z7xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE A 120
ILE A 181
LEU A 115
LEU A 139
TYR A 136
 None
 1.16A 4xumA-2z7xA:
undetectable		 4xumA-2z7xA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 LEU A 367
VAL A 343
ILE A 341
LEU A 412
LEU A 389
 None
 1.15A 4yvpB-2z7xA:
undetectable		 4yvpB-2z7xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU A 377
THR A 411
LEU A 412
THR A 408
 None
 0.96A 4z91F-2z7xA:
undetectable
4z91G-2z7xA:
undetectable
4z91H-2z7xA:
undetectable
4z91I-2z7xA:
undetectable
4z91J-2z7xA:
undetectable		 4z91F-2z7xA:
20.11
4z91G-2z7xA:
20.11
4z91H-2z7xA:
20.11
4z91I-2z7xA:
20.11
4z91J-2z7xA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 1.00A 5b1bA-2z7xB:
undetectable
5b1bJ-2z7xB:
undetectable		 5b1bA-2z7xB:
23.01
5b1bJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		3 / 3 ARG B 441
LYS B 415
GLU B 414
 None
 0.73A 5d0yA-2z7xB:
undetectable		 5d0yA-2z7xB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 9 LEU A 399
THR A 405
LEU A 409
ILE A 418
PRO A 456
 None
 1.37A 5g48B-2z7xA:
undetectable		 5g48B-2z7xA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 LEU A 282
LEU A 331
PHE A 284
LEU A 266
 None
 1.02A 5gtrA-2z7xA:
undetectable		 5gtrA-2z7xA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 LEU A 282
LEU A 334
PHE A 284
LEU A 266
 None
 1.05A 5gtrA-2z7xA:
undetectable		 5gtrA-2z7xA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.95A 5iy5A-2z7xB:
undetectable
5iy5J-2z7xB:
undetectable		 5iy5A-2z7xB:
23.01
5iy5J-2z7xB:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 428
GLU B 472
ASN B 455
ILE B 457
 None
 1.03A 5jh7C-2z7xB:
undetectable		 5jh7C-2z7xB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 VAL A 464
LEU A 469
LEU A 482
LEU A 479
 None
 0.66A 5jq7A-2z7xA:
undetectable		 5jq7A-2z7xA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 ASN B 382
LEU B 384
SER B 406
LEU B 403
 None
None
NAG  A 831 (-3.0A)
None
 1.18A 5kb5A-2z7xB:
undetectable		 5kb5A-2z7xB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 ASN B 433
LEU B 435
SER B 431
LEU B 450
 None
None
NAG  A 831 (-3.6A)
None
 1.35A 5kb5A-2z7xB:
undetectable		 5kb5A-2z7xB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 ASN A 467
LEU A 469
SER A 465
LEU A 482
 None
 1.39A 5kb5A-2z7xA:
undetectable		 5kb5A-2z7xA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 4 ASN A 467
LEU A 469
SER A 485
LEU A 482
 None
 1.15A 5kb5A-2z7xA:
undetectable		 5kb5A-2z7xA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 LEU B 121
VAL B  88
TYR B  83
SER B  87
 None
 1.29A 5umwA-2z7xB:
undetectable
5umwF-2z7xB:
undetectable		 5umwA-2z7xB:
9.13
5umwF-2z7xB:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		5 / 12 PHE B 233
LEU B 171
PHE B 202
LEU B 251
LEU B 216
 None
 1.36A 5y2oA-2z7xB:
undetectable		 5y2oA-2z7xB:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 8 ASP A 419
ARG A 395
LYS A 422
VAL A 451
 NAG  A 921 ( 3.9A)
None
None
None
 1.04A 6fbvD-2z7xA:
undetectable		 6fbvD-2z7xA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 7 ILE B 447
LEU B 450
THR B 492
LEU B 491
 None
 0.92A 6nmpA-2z7xB:
undetectable
6nmpJ-2z7xB:
undetectable		 6nmpA-2z7xB:
23.01
6nmpJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens) 		4 / 5 ILE B 447
LEU B 450
THR B 492
LEU B 491
 None
 0.92A 6nmpN-2z7xB:
undetectable
6nmpW-2z7xB:
undetectable		 6nmpN-2z7xB:
23.01
6nmpW-2z7xB:
8.05