SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 LEU A 362
PHE A 364
LEU A 392
LEU A 389
 None
 0.88A 1e7cA-2z81A:
undetectable		 1e7cA-2z81A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 TRP A 434
PRO A 435
LEU A 415
LEU A 392
ALA A 381
 None
 1.46A 1hk3A-2z81A:
undetectable		 1hk3A-2z81A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 PHE A 120
SER A 116
TRP A 119
ALA A  95
GLY A 121
 None
None
None
None
NAG  A 821 ( 4.9A)
 1.46A 1jb0A-2z81A:
undetectable		 1jb0A-2z81A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 LEU A 367
VAL A 343
ILE A 341
LEU A 412
LEU A 389
 None
PCJ  A   1 (-4.8A)
PCJ  A   1 ( 4.6A)
None
None
 1.21A 1mrqA-2z81A:
undetectable		 1mrqA-2z81A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 525
PHE A 519
SER A 485
ILE A 506
LEU A 492
 None
 1.02A 1rx3A-2z81A:
undetectable		 1rx3A-2z81A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 269
LEU A 272
MET A 251
LEU A 229
LEU A 227
 None
 1.12A 1sqnB-2z81A:
undetectable		 1sqnB-2z81A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		3 / 3 ASP A  58
ARG A  39
ASP A 106
 None
 0.68A 1vptA-2z81A:
undetectable		 1vptA-2z81A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 PHE A 162
LEU A 139
LEU A 154
LEU A 179
 None
 0.94A 2bfpB-2z81A:
undetectable		 2bfpB-2z81A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 PHE A 162
LEU A 139
LEU A 154
LEU A 179
 None
 1.00A 2bfpC-2z81A:
undetectable		 2bfpC-2z81A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 TYR A 128
ASP A 106
SER A 108
TYR A 136
 None
 1.30A 2bteA-2z81A:
undetectable		 2bteA-2z81A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 LEU A  59
ARG A  41
PHE A  43
LEU A  57
LEU A  50
 None
 1.09A 2bxeA-2z81A:
undetectable		 2bxeA-2z81A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 811 ( 4.3A)
None
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.02A 2cmlA-2z81A:
undetectable		 2cmlA-2z81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 811 ( 4.3A)
None
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 0.91A 2cmlB-2z81A:
undetectable		 2cmlB-2z81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 811 ( 4.3A)
None
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.01A 2cmlC-2z81A:
undetectable		 2cmlC-2z81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 811 ( 4.3A)
None
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.08A 2cmlD-2z81A:
undetectable		 2cmlD-2z81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 ILE A 165
LEU A 186
GLY A 157
ASN A 158
ILE A 156
 None
 1.32A 2e7fB-2z81A:
undetectable		 2e7fB-2z81A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 6 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 0.94A 2einN-2z81A:
undetectable
2einW-2z81A:
undetectable		 2einN-2z81A:
19.70
2einW-2z81A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 LEU A 525
LEU A 522
ILE A 518
LEU A 530
ILE A 528
 None
 1.24A 2f78B-2z81A:
undetectable		 2f78B-2z81A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 LEU A 154
LEU A 179
ILE A 181
PHE A 170
LEU A 139
 None
 1.23A 2f7aB-2z81A:
undetectable		 2f7aB-2z81A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 5 LEU A 179
ASP A 169
LEU A 227
HIS A 206
 None
 1.27A 2jfaA-2z81A:
undetectable		 2jfaA-2z81A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A  72
PHE A  96
LEU A  78
ILE A  88
SER A  56
 None
 1.31A 2pnjB-2z81A:
undetectable		 2pnjB-2z81A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 LEU A 362
LEU A 389
LEU A 412
ILE A 341
VAL A 351
 None
None
None
PCJ  A   1 ( 4.6A)
PCJ  A   1 ( 4.0A)
 1.06A 2qd3A-2z81A:
undetectable		 2qd3A-2z81A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 5 LEU A 179
ASP A 169
LEU A 227
HIS A 206
 None
 1.31A 2qxsA-2z81A:
undetectable		 2qxsA-2z81A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 5 LEU A 179
ASP A 169
LEU A 227
HIS A 206
 None
 1.31A 2qxsB-2z81A:
undetectable		 2qxsB-2z81A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 5 TYR A 189
ILE A 165
LEU A 207
LEU A 205
 None
 1.06A 2zb7A-2z81A:
undetectable		 2zb7A-2z81A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 6 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 0.85A 3ag1N-2z81A:
undetectable
3ag1W-2z81A:
undetectable		 3ag1N-2z81A:
19.70
3ag1W-2z81A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 LEU A 377
LEU A 392
SER A 395
ASN A 397
 None
None
NAG  A 811 ( 4.1A)
None
 0.98A 3lm8B-2z81A:
undetectable
3lm8D-2z81A:
undetectable		 3lm8B-2z81A:
18.74
3lm8D-2z81A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 LEU A  57
LEU A  81
LEU A  59
ASN A  62
SER A  86
 None
 1.39A 3ndvC-2z81A:
undetectable
3ndvD-2z81A:
undetectable		 3ndvC-2z81A:
22.20
3ndvD-2z81A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 8 ASP A 245
VAL A 247
ILE A 197
PRO A 250
 None
 0.75A 3nu9A-2z81A:
undetectable		 3nu9A-2z81A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.95A 3p50A-2z81A:
undetectable		 3p50A-2z81A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.95A 3p50B-2z81A:
undetectable		 3p50B-2z81A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.96A 3p50C-2z81A:
undetectable		 3p50C-2z81A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.96A 3p50D-2z81A:
undetectable		 3p50D-2z81A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.96A 3p50E-2z81A:
undetectable		 3p50E-2z81A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 PHE A 120
SER A 116
TRP A 119
ALA A  95
GLY A 121
 None
None
None
None
NAG  A 821 ( 4.9A)
 1.46A 3pcqA-2z81A:
undetectable		 3pcqA-2z81A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 5 GLY A 258
ASP A 286
ARG A 257
MET A 132
 None
 1.05A 3qx3B-2z81A:
undetectable		 3qx3B-2z81A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		3 / 3 GLN A 152
GLU A 103
LYS A 127
 None
 1.08A 3su9A-2z81A:
undetectable		 3su9A-2z81A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 TYR A 128
ASP A 106
SER A 108
TYR A 136
 None
 1.23A 4arcA-2z81A:
undetectable		 4arcA-2z81A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 PHE A 120
ASP A 169
LEU A 186
GLY A 157
ILE A 156
 None
 1.49A 4djeA-2z81A:
undetectable		 4djeA-2z81A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 10 PHE A 120
SER A 116
TRP A 119
ALA A  95
GLY A 121
 None
None
None
None
NAG  A 821 ( 4.9A)
 1.48A 4fe1A-2z81A:
undetectable
4fe1J-2z81A:
undetectable		 4fe1A-2z81A:
20.18
4fe1J-2z81A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		3 / 3 ASP A 231
ARG A 230
ASP A 286
 None
 0.80A 4fp9D-2z81A:
undetectable		 4fp9D-2z81A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		3 / 3 ASP A  58
ARG A  39
ASP A 106
 None
 0.81A 4fzvA-2z81A:
undetectable		 4fzvA-2z81A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 SER A 249
LEU A 221
VAL A 224
ILE A 220
LEU A 205
 None
 1.14A 4k36A-2z81A:
undetectable		 4k36A-2z81A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 SER A 249
LEU A 221
VAL A 224
ILE A 220
LEU A 205
 None
 1.10A 4k37A-2z81A:
undetectable		 4k37A-2z81A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 11 SER A 249
LEU A 221
VAL A 224
ILE A 220
LEU A 205
 None
 1.07A 4k37B-2z81A:
undetectable		 4k37B-2z81A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 SER A 249
LEU A 221
VAL A 224
ILE A 220
LEU A 205
 None
 1.21A 4k38A-2z81A:
undetectable
4k38D-2z81A:
undetectable		 4k38A-2z81A:
21.94
4k38D-2z81A:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 VAL A  35
LEU A  50
LEU A 102
LEU A 126
LYS A 127
 None
 1.34A 4rtbA-2z81A:
undetectable		 4rtbA-2z81A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 PHE A 120
ILE A 181
LEU A 115
LEU A 139
TYR A 136
 None
 1.10A 4xumA-2z81A:
undetectable		 4xumA-2z81A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 PHE A 120
SER A 116
TRP A 119
ALA A  95
GLY A 121
 None
None
None
None
NAG  A 821 ( 4.9A)
 1.48A 4y28A-2z81A:
undetectable
4y28J-2z81A:
0.0		 4y28A-2z81A:
21.50
4y28J-2z81A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 10 SER A  60
LEU A  72
SER A 108
LEU A 107
LEU A 123
 None
 1.21A 4yiaA-2z81A:
undetectable		 4yiaA-2z81A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 367
VAL A 343
ILE A 341
LEU A 412
LEU A 389
 None
PCJ  A   1 (-4.8A)
PCJ  A   1 ( 4.6A)
None
None
 1.16A 4yvpB-2z81A:
undetectable		 4yvpB-2z81A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		6 / 12 ASP A  71
GLY A  70
ASP A  94
ILE A  91
ILE A  64
ILE A  67
 None
 1.45A 5e5kB-2z81A:
undetectable		 5e5kB-2z81A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 165
ILE A 220
PHE A 170
LEU A 213
 None
 0.63A 5fukA-2z81A:
undetectable
5fukB-2z81A:
undetectable		 5fukA-2z81A:
19.20
5fukB-2z81A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 PHE A 256
LEU A 273
LEU A 270
PHE A 284
LEU A 335
 None
None
None
PCJ  A   1 (-3.9A)
None
 1.12A 5iepA-2z81A:
undetectable		 5iepA-2z81A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 6 TYR A 136
ASP A 109
ILE A  88
TYR A 128
 None
 1.29A 5igyA-2z81A:
undetectable		 5igyA-2z81A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 6 TYR A 136
ASP A 109
ILE A  88
TYR A 128
 None
 1.25A 5ih0A-2z81A:
undetectable		 5ih0A-2z81A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 VAL A 464
LEU A 469
LEU A 482
LEU A 479
 None
 0.62A 5jq7A-2z81A:
undetectable		 5jq7A-2z81A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 4 ASN A 397
LEU A 399
SER A 395
LEU A 418
 None
None
NAG  A 811 ( 4.1A)
None
 1.38A 5kb5A-2z81A:
undetectable		 5kb5A-2z81A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 4 ASN A 397
LEU A 399
SER A 421
LEU A 418
 None
None
NAG  A 811 (-3.4A)
None
 1.21A 5kb5A-2z81A:
undetectable		 5kb5A-2z81A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 PHE A 120
SER A 116
TRP A 119
ALA A  95
GLY A 121
 None
None
None
None
NAG  A 821 ( 4.9A)
 1.47A 5l8rA-2z81A:
undetectable		 5l8rA-2z81A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 269
LEU A 272
MET A 251
LEU A 221
LEU A 227
 None
 1.05A 5mwyA-2z81A:
undetectable		 5mwyA-2z81A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A 269
LEU A 272
MET A 251
SER A 249
LEU A 227
 None
 1.04A 5mwyA-2z81A:
undetectable		 5mwyA-2z81A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 LEU A 270
VAL A 331
LEU A 334
ILE A 314
LEU A 261
 None
None
None
None
PCJ  A   1 ( 4.5A)
 1.26A 5og9A-2z81A:
undetectable		 5og9A-2z81A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 0.95A 5xdqA-2z81A:
undetectable
5xdqJ-2z81A:
undetectable		 5xdqA-2z81A:
19.70
5xdqJ-2z81A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 0.95A 5xdqN-2z81A:
undetectable
5xdqW-2z81A:
undetectable		 5xdqN-2z81A:
19.70
5xdqW-2z81A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 10 PHE A 120
SER A 116
TRP A 119
ILE A  67
ALA A  95
 None
 1.47A 5zjiA-2z81A:
undetectable
5zjiJ-2z81A:
undetectable		 5zjiA-2z81A:
8.04
5zjiJ-2z81A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_B_6T0B913_0
(TOLL-LIKE RECEPTOR 7)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 9 TYR A 544
VAL A 514
PHE A 519
LEU A 549
ILE A 528
 None
 1.30A 5zsfA-2z81A:
16.6
5zsfB-2z81A:
17.5		 5zsfA-2z81A:
9.26
5zsfB-2z81A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		5 / 12 LEU A  83
ALA A  95
PRO A 122
GLY A 100
LEU A 123
 None
 1.09A 6b0iB-2z81A:
undetectable		 6b0iB-2z81A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 LEU A 194
LEU A 179
LEU A 176
LEU A 139
 None
 0.71A 6g9bA-2z81A:
undetectable
6g9bB-2z81A:
undetectable		 6g9bA-2z81A:
8.93
6g9bB-2z81A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 LEU A 497
VAL A 451
LEU A 489
LEU A 462
 None
 0.73A 6g9bA-2z81A:
undetectable
6g9bB-2z81A:
undetectable		 6g9bA-2z81A:
8.93
6g9bB-2z81A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Mus
musculus) 		4 / 7 ILE A 420
MET A 438
THR A 416
LEU A 415
 None
 0.80A 6nmpA-2z81A:
undetectable
6nmpJ-2z81A:
undetectable		 6nmpA-2z81A:
19.70
6nmpJ-2z81A:
8.19