SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 8 VAL A 601
HIS A 268
GLU A 491
ASP A 598
 None
 1.22A 1s3zA-2z83A:
undetectable
1s3zB-2z83A:
undetectable		 1s3zA-2z83A:
18.59
1s3zB-2z83A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		5 / 11 TYR A 473
GLY A 476
ARG A 427
THR A 479
ILE A 450
 None
 1.48A 2f9wA-2z83A:
undetectable
2f9wB-2z83A:
2.0		 2f9wA-2z83A:
20.48
2f9wB-2z83A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		5 / 8 TYR A 473
GLY A 476
ARG A 427
THR A 479
ILE A 450
 None
 1.48A 2f9wA-2z83A:
undetectable
2f9wB-2z83A:
2.4		 2f9wA-2z83A:
20.48
2f9wB-2z83A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		3 / 3 LYS A 399
TYR A 395
PRO A 396
 None
 1.48A 2j9cC-2z83A:
undetectable		 2j9cC-2z83A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		5 / 12 ILE A 204
LEU A 194
ILE A 208
PRO A 319
VAL A 260
 None
 0.98A 2ygqA-2z83A:
undetectable		 2ygqA-2z83A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 7 VAL A 221
ILE A 301
MET A 495
ARG A 242
 None
 1.30A 3ms9B-2z83A:
undetectable		 3ms9B-2z83A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 5 VAL A 221
ILE A 301
MET A 495
ARG A 242
 None
 1.34A 3oezA-2z83A:
undetectable		 3oezA-2z83A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 5 VAL A 221
ILE A 301
MET A 495
ARG A 242
 None
 1.26A 3pyyB-2z83A:
undetectable		 3pyyB-2z83A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 7 THR A 408
VAL A 423
ASP A 425
VAL A 360
 None
 0.98A 4cp4A-2z83A:
undetectable		 4cp4A-2z83A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 5 LEU A 222
ASP A 291
GLU A 286
VAL A 227
 None
 1.14A 4nkvA-2z83A:
undetectable		 4nkvA-2z83A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		3 / 3 PRO A 512
ARG A 514
GLU A 513
 None
 0.98A 5j6hA-2z83A:
undetectable		 5j6hA-2z83A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		5 / 10 VAL A 406
ILE A 384
GLY A 419
ALA A 420
PHE A 418
 None
 1.06A 5mxbA-2z83A:
undetectable		 5mxbA-2z83A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE
(Japanese
encephalitis
virus) 		4 / 8 TRP A 546
GLU A 439
TRP A 563
ASN A 554
 None
 1.21A 6c71B-2z83A:
undetectable		 6c71B-2z83A:
12.22