SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z87'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 6 TYR A 665
TRP A 114
ILE A 110
LEU A 610
 None
 1.31A 1j96A-2z87A:
undetectable		 1j96A-2z87A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 237
ASP A 239
GLY A 336
GLY A 335
LEU A 227
 None
UD2  A 683 (-3.4A)
UD2  A 683 (-3.5A)
UD2  A 683 ( 4.8A)
None
 0.83A 1liiA-2z87A:
undetectable		 1liiA-2z87A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 GLY A 335
ALA A 236
PHE A 333
LEU A 369
PHE A 351
 UD2  A 683 ( 4.8A)
None
None
None
None
 1.27A 1nw3A-2z87A:
undetectable		 1nw3A-2z87A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 6 LEU A 573
THR A 548
TYR A 546
TYR A 606
 None
 0.85A 1qvuA-2z87A:
undetectable		 1qvuA-2z87A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 TYR A 417
GLY A 359
GLY A 360
GLU A 361
LEU A 219
 None
UD2  A 683 ( 4.3A)
None
UD2  A 683 (-3.6A)
UD2  A 683 (-3.7A)
 1.05A 1qzzA-2z87A:
3.0		 1qzzA-2z87A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		3 / 3 GLN A 517
ILE A 438
TYR A 437
 None
 0.76A 1vifA-2z87A:
undetectable		 1vifA-2z87A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 7 TYR A 415
SER A 541
THR A 127
ASN A 327
 None
 1.02A 2i91A-2z87A:
undetectable		 2i91A-2z87A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 7 TYR A 415
SER A 541
THR A 127
ASN A 327
 None
 1.02A 2i91B-2z87A:
undetectable		 2i91B-2z87A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 474
TYR A 483
SER A 444
CYH A 443
 None
 1.15A 2xz5C-2z87A:
undetectable
2xz5D-2z87A:
undetectable		 2xz5C-2z87A:
16.75
2xz5D-2z87A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A 585
ASP A 607
ILE A 600
GLY A 500
ASN A 504
 None
 0.97A 2ycjA-2z87A:
undetectable		 2ycjA-2z87A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		3 / 3 GLU A 463
VAL A 489
CYH A 465
 None
 0.96A 3fbxA-2z87A:
undetectable		 3fbxA-2z87A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 168
ILE A 154
VAL A 185
LYS A 208
ILE A 207
 None
 1.40A 3ijdA-2z87A:
1.7		 3ijdA-2z87A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A 282
LEU A 204
CYH A 173
ASN A 174
 None
 1.00A 3lm8A-2z87A:
undetectable
3lm8C-2z87A:
2.7		 3lm8A-2z87A:
17.52
3lm8C-2z87A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 8 LEU A 282
LEU A 204
CYH A 173
ASN A 174
 None
 1.03A 3lm8B-2z87A:
2.2
3lm8D-2z87A:
undetectable		 3lm8B-2z87A:
17.52
3lm8D-2z87A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 6 ARG A 583
GLN A 517
PHE A 585
LEU A 612
 None
 1.37A 3tgvB-2z87A:
undetectable		 3tgvB-2z87A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 11 VAL A 183
ASN A 337
PRO A 244
TYR A 385
LEU A 172
 None
 1.22A 3v8vB-2z87A:
2.1		 3v8vB-2z87A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 165
LEU A 172
CYH A 173
ILE A 207
ILE A 156
 None
 0.90A 4a79A-2z87A:
undetectable		 4a79A-2z87A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 165
LEU A 172
CYH A 173
ILE A 207
ILE A 156
 None
 0.89A 4a79B-2z87A:
undetectable		 4a79B-2z87A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A 165
LEU A 172
CYH A 173
ILE A 207
ILE A 156
 None
 0.92A 4a7aA-2z87A:
undetectable		 4a7aA-2z87A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 165
LEU A 172
CYH A 173
ILE A 207
ILE A 156
 None
 0.90A 4a7aB-2z87A:
undetectable		 4a7aB-2z87A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 5 PHE A 340
PHE A 351
ILE A 237
GLY A 335
 None
None
None
UD2  A 683 ( 4.8A)
 0.99A 4ejjC-2z87A:
undetectable		 4ejjC-2z87A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 8 ASP A 239
VAL A 338
PHE A 351
LEU A 227
 UD2  A 683 (-3.4A)
None
None
None
 1.09A 4f8hB-2z87A:
undetectable
4f8hC-2z87A:
undetectable		 4f8hB-2z87A:
20.52
4f8hC-2z87A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 550
GLU A 100
ASN A 561
 None
 0.64A 4imaD-2z87A:
4.7		 4imaD-2z87A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		3 / 3 ARG A 550
GLU A 100
ASN A 561
 None
 0.71A 4ip7D-2z87A:
4.5		 4ip7D-2z87A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 10 LEU A 219
PHE A 333
GLU A 361
PHE A 340
LEU A 227
 UD2  A 683 (-3.7A)
None
UD2  A 683 (-3.6A)
None
None
 1.39A 4la0A-2z87A:
undetectable		 4la0A-2z87A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 11 LEU A 238
ASP A 187
VAL A 185
ILE A 167
ILE A 156
 None
 1.00A 4njtA-2z87A:
undetectable		 4njtA-2z87A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 7 PRO A 432
THR A  67
ILE A  63
ASP A  64
 None
 1.03A 4pcuA-2z87A:
3.1		 4pcuA-2z87A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 8 VAL A 107
HIS A 620
HIS A 580
ASN A 564
 None
 0.86A 5a5zA-2z87A:
undetectable		 5a5zA-2z87A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 246
ILE A 265
SER A 286
 None
 0.73A 5fsaA-2z87A:
undetectable		 5fsaA-2z87A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		4 / 4 PHE A 340
ASP A 260
LEU A 345
LYS A 343
 None
 1.15A 6awvA-2z87A:
undetectable		 6awvA-2z87A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 12 ILE A 660
SER A 575
TYR A 677
LEU A 658
LEU A 610
 None
 1.35A 6chgC-2z87A:
undetectable		 6chgC-2z87A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2z87 CHONDROITIN SYNTHASE
(Escherichia
coli) 		5 / 9 LEU A 479
THR A 475
ILE A 447
VAL A 451
ILE A 466
 None
 1.25A 6ef6A-2z87A:
undetectable		 6ef6A-2z87A:
20.78