SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		3 / 3 VAL A  75
VAL A  42
TRP A  66
 None
 0.63A 1av2A-2z8eA:
undetectable
1av2B-2z8eA:
undetectable		 1av2A-2z8eA:
2.70
1av2B-2z8eA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 11 LEU A 334
GLY A 150
VAL A 114
LEU A 120
LEU A 103
 None
 1.15A 1mx1B-2z8eA:
undetectable		 1mx1B-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 LEU A 334
GLY A 150
LEU A 111
LEU A 120
LEU A 103
 None
 1.26A 1mx1C-2z8eA:
undetectable		 1mx1C-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 LEU A 334
GLY A 150
VAL A 114
LEU A 120
LEU A 103
 None
 1.14A 1mx1C-2z8eA:
undetectable		 1mx1C-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		6 / 12 LEU A 334
GLY A 150
VAL A 114
LEU A 111
LEU A 120
LEU A 103
 None
 1.24A 1mx1D-2z8eA:
undetectable		 1mx1D-2z8eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 9 GLY A 268
PHE A 367
PHE A 167
LEU A 170
ILE A 196
 None
 1.35A 1oltA-2z8eA:
0.0		 1oltA-2z8eA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		3 / 3 VAL A  75
VAL A  42
TRP A  66
 None
 0.58A 1w5uA-2z8eA:
undetectable
1w5uB-2z8eA:
undetectable		 1w5uA-2z8eA:
2.70
1w5uB-2z8eA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		3 / 3 GLN A 347
HIS A  48
ARG A  49
 None
None
NGA  A   2 (-3.0A)
 1.08A 1zlqA-2z8eA:
1.0		 1zlqA-2z8eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 THR A 290
GLY A 291
GLY A 293
ILE A 265
PHE A 283
 None
 1.29A 2akeA-2z8eA:
undetectable		 2akeA-2z8eA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 THR A 290
GLY A 291
GLY A 293
ILE A 265
PHE A 283
 None
 1.29A 2azxA-2z8eA:
undetectable		 2azxA-2z8eA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 THR A 290
GLY A 291
GLY A 293
ILE A 265
PHE A 283
 None
 1.33A 2azxB-2z8eA:
undetectable		 2azxB-2z8eA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 5 ASN A 338
PHE A 134
VAL A 142
ALA A 317
 None
 1.16A 2cizA-2z8eA:
undetectable		 2cizA-2z8eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 GLY A 385
PHE A 304
GLY A 213
GLY A 216
PHE A 241
 None
 1.10A 2dpmA-2z8eA:
undetectable		 2dpmA-2z8eA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		3 / 3 VAL A  42
TRP A  66
VAL A  75
 None
 0.64A 2izqC-2z8eA:
undetectable
2izqD-2z8eA:
undetectable		 2izqC-2z8eA:
2.70
2izqD-2z8eA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 GLY A 210
GLY A 315
GLY A 156
GLY A 311
LEU A 349
 None
GAL  A   1 (-3.2A)
None
None
None
 0.94A 2oxtA-2z8eA:
undetectable		 2oxtA-2z8eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 6 TRP A 218
GLY A 305
GLY A 311
PHE A 418
 None
 0.94A 2qx6A-2z8eA:
undetectable
2qx6B-2z8eA:
undetectable		 2qx6A-2z8eA:
22.36
2qx6B-2z8eA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 4 LYS A 309
ALA A 214
PHE A 387
GLY A 210
 None
 1.33A 2rddA-2z8eA:
1.0		 2rddA-2z8eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 12 TYR A 162
PHE A 182
TYR A 160
ALA A 186
ALA A 189
 None
 1.34A 2x2nD-2z8eA:
undetectable		 2x2nD-2z8eA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 SER A 260
PHE A 261
ASP A 202
LEU A 282
 None
None
None
NGA  A   2 (-4.8A)
 1.08A 3jq7B-2z8eA:
undetectable		 3jq7B-2z8eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 SER A 260
PHE A 261
ASP A 202
LEU A 282
 None
None
None
NGA  A   2 (-4.8A)
 1.06A 3jq7C-2z8eA:
undetectable		 3jq7C-2z8eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 THR A 124
GLY A 146
GLY A 145
VAL A 144
 None
 0.83A 4qvvK-2z8eA:
undetectable
4qvvL-2z8eA:
undetectable		 4qvvK-2z8eA:
20.53
4qvvL-2z8eA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 THR A 124
GLY A 146
GLY A 145
VAL A 144
 None
 0.83A 4qvvY-2z8eA:
undetectable
4qvvZ-2z8eA:
undetectable		 4qvvY-2z8eA:
20.53
4qvvZ-2z8eA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 6 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.94A 5eckA-2z8eA:
undetectable		 5eckA-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 6 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.90A 5eckD-2z8eA:
undetectable		 5eckD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 6 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.84A 5eclA-2z8eA:
undetectable		 5eclA-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 6 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.81A 5eclD-2z8eA:
undetectable		 5eclD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.61A 5ecnD-2z8eA:
undetectable		 5ecnD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 7 ALA A  77
VAL A  75
VAL A 318
HIS A  48
 None
 0.76A 5ecoD-2z8eA:
undetectable		 5ecoD-2z8eA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		5 / 9 TYR A 160
ILE A 172
LEU A 170
ILE A 271
GLY A 272
 None
 0.79A 5ifuB-2z8eA:
undetectable		 5ifuB-2z8eA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Bifidobacterium
longum) 		4 / 8 LEU A 344
LEU A 151
GLY A 150
TYR A  46
 None
 0.95A 6ce2A-2z8eA:
undetectable		 6ce2A-2z8eA:
14.06