SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		5 / 11 GLU A  85
ILE A  88
ASN A  25
ASP A  31
PHE A  45
 None
 1.24A 1hvyC-2z8hA:
undetectable		 1hvyC-2z8hA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 7 ILE A  88
ARG A  44
THR A  74
LEU A  75
 None
 1.01A 1v54N-2z8hA:
undetectable
1v54W-2z8hA:
undetectable		 1v54N-2z8hA:
13.03
1v54W-2z8hA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 6 LEU A  98
VAL A  51
VAL A 115
ILE A  88
 None
 1.11A 3k5vA-2z8hA:
undetectable		 3k5vA-2z8hA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 6 LEU A  98
VAL A  51
VAL A 115
ILE A  88
 None
 1.12A 3k5vB-2z8hA:
undetectable		 3k5vB-2z8hA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 6 ILE A  88
ARG A  44
THR A  74
LEU A  75
 None
 0.96A 3wg7N-2z8hA:
undetectable
3wg7W-2z8hA:
undetectable		 3wg7N-2z8hA:
13.03
3wg7W-2z8hA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 6 ILE A  88
ARG A  44
THR A  74
LEU A  75
 None
 1.03A 5z86N-2z8hA:
undetectable
5z86W-2z8hA:
undetectable		 5z86N-2z8hA:
13.03
5z86W-2z8hA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 6 ILE A  88
ARG A  44
THR A  74
LEU A  75
 None
 1.02A 5zcoN-2z8hA:
undetectable
5zcoW-2z8hA:
undetectable		 5zcoN-2z8hA:
13.03
5zcoW-2z8hA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2z8h TRANSCRIPTION
REGULATOR PROTEIN
BACH1
(Mus
musculus) 		4 / 5 PHE A  45
VAL A 115
PRO A  86
VAL A  81
 None
 1.36A 6ekzA-2z8hA:
undetectable		 6ekzA-2z8hA:
15.94