SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GJ5_A_VD3A163_1 (BETA-LACTOGLOBULIN)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	5 / 12	LEU A 157 VAL A 142 LEU A 137 ILE A 170 ALA A 105	None	1.08A	2gj5A-2z8uA: undetectable	2gj5A-2z8uA: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_A_SAMA302_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	5 / 12	GLY A 132 GLY A 150 GLY A 148 ILE A 109 LEU A 171	None	0.76A	2nxeA-2z8uA: undetectable	2nxeA-2z8uA: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NXE_B_SAMB303_0 (RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	5 / 12	GLY A 132 GLY A 150 GLY A 148 ILE A 109 LEU A 171	None	0.79A	2nxeB-2z8uA: undetectable	2nxeB-2z8uA: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYR_B_SVRB401_3 (NAD-DEPENDENT DEACETYLASE SIRTUIN-5)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	5 / 12	PHE A 147 GLY A 148 ASN A 112 VAL A 134 TYR A 125	None	1.43A	2nyrB-2z8uA: undetectable	2nyrB-2z8uA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q5K_A_AB1A201_1 (PROTEASE)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	5 / 9	ALA A 163 ASP A 162 ILE A 170 PRO A 3 ILE A 5	None	1.08A	2q5kA-2z8uA: undetectable	2q5kA-2z8uA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9J_C_TYLC1184_1 (BROMODOMAIN CONTAINING 2)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	4 / 5	VAL A 25 LEU A 42 LEU A 22 ILE A 16	None	0.94A	4a9jC-2z8uA: undetectable	4a9jC-2z8uA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LZR_A_LOCA201_1 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	4 / 8	VAL A 25 LEU A 42 LEU A 22 ILE A 16	None	0.88A	4lzrA-2z8uA: undetectable	4lzrA-2z8uA: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_B_SAMB901_0 (MRNA CAPPING ENZYME P5)	2z8u	TATA-BOX-BINDING PROTEIN (Methanocaldococc us jannaschii)	5 / 10	VAL A 51 GLY A 65 ALA A 75 LEU A 53 ASN A 62	None	0.96A	5x6yB-2z8uA: undetectable	5x6yB-2z8uA: 12.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2GJ5_A_VD3A163_1","BETA-LACTOGLOBULIN","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",5,"LEU A 157;VAL A 142;LEU A 137;ILE A 170;ALA A 105","None","1.08A","2gj5A-2z8uA:undetectable","2gj5A-2z8uA:23.50"],["2NXE_A_SAMA302_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",5,"GLY A 132;GLY A 150;GLY A 148;ILE A 109;LEU A 171","None","0.76A","2nxeA-2z8uA:undetectable","2nxeA-2z8uA:21.91"],["2NXE_B_SAMB303_0","RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",5,"GLY A 132;GLY A 150;GLY A 148;ILE A 109;LEU A 171","None","0.79A","2nxeB-2z8uA:undetectable","2nxeB-2z8uA:21.91"],["2NYR_B_SVRB401_3","NAD-DEPENDENT DEACETYLASE SIRTUIN-5","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",5,"PHE A 147;GLY A 148;ASN A 112;VAL A 134;TYR A 125","None","1.43A","2nyrB-2z8uA:undetectable","2nyrB-2z8uA:20.00"],["2Q5K_A_AB1A201_1","PROTEASE","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",5,"ALA A 163;ASP A 162;ILE A 170;PRO A   3;ILE A   5","None","1.08A","2q5kA-2z8uA:undetectable","2q5kA-2z8uA:20.00"],["4A9J_C_TYLC1184_1","BROMODOMAIN CONTAINING 2","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",4,"VAL A  25;LEU A  42;LEU A  22;ILE A  16","None","0.94A","4a9jC-2z8uA:undetectable","4a9jC-2z8uA:23.71"],["4LZR_A_LOCA201_1","BROMODOMAIN-CONTAINING PROTEIN 4","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",4,"VAL A  25;LEU A  42;LEU A  22;ILE A  16","None","0.88A","4lzrA-2z8uA:undetectable","4lzrA-2z8uA:19.90"],["5X6Y_B_SAMB901_0","MRNA CAPPING ENZYME P5","2z8u","TATA-BOX-BINDING PROTEIN","Methanocaldococcus jannaschii",5,"VAL A  51;GLY A  65;ALA A  75;LEU A  53;ASN A  62","None","0.96A","5x6yB-2z8uA:undetectable","5x6yB-2z8uA:12.73"]]