SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 ASN A 344
ALA A 317
GLY A 319
TYR A 318
 None
 0.86A 1c8lA-2z8zA:
undetectable		 1c8lA-2z8zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 ASN A 344
ALA A 317
GLY A 319
TYR A 318
 None
 0.92A 1gfzA-2z8zA:
undetectable		 1gfzA-2z8zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 5 THR A 143
LEU A 211
GLY A 209
TYR A 175
 None
 1.32A 1gtiF-2z8zA:
undetectable		 1gtiF-2z8zA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 11 GLY A 549
GLY A 569
LEU A 568
ASP A 554
GLY A 552
 None
None
None
CA  A 627 (-2.5A)
CA  A 627 ( 4.4A)
 1.13A 1jg3A-2z8zA:
undetectable		 1jg3A-2z8zA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 ASN A 344
ALA A 317
GLY A 321
TYR A 318
 None
 1.12A 1l5qA-2z8zA:
undetectable		 1l5qA-2z8zA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 ASN A 344
ALA A 317
GLY A 321
TYR A 318
 None
 1.07A 1l7xB-2z8zA:
undetectable		 1l7xB-2z8zA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ASN A 548
ASP A 534
GLY A 529
GLY A 530
ASP A 513
 None
CA  A 625 ( 2.4A)
CA  A 625 (-4.4A)
CA  A 625 (-4.3A)
None
 1.09A 1likA-2z8zA:
undetectable		 1likA-2z8zA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 TYR A   4
GLU A 390
TYR A 252
GLY A 251
 None
 1.14A 1maaB-2z8zA:
2.7
1maaD-2z8zA:
undetectable		 1maaB-2z8zA:
23.20
1maaD-2z8zA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 5 GLY A 226
TRP A 224
VAL A 188
SER A 231
 None
 1.35A 1p6kB-2z8zA:
undetectable		 1p6kB-2z8zA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 7 LEU A 261
ASN A 160
ILE A 159
ASP A 161
 None
 0.98A 1yc2E-2z8zA:
undetectable		 1yc2E-2z8zA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 5 GLY A 226
TRP A 224
VAL A 188
SER A 231
 None
 1.37A 1zzuB-2z8zA:
undetectable		 1zzuB-2z8zA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 7 ASN A 249
THR A  25
GLY A 205
TYR A 236
 None
 1.04A 2f6dA-2z8zA:
undetectable		 2f6dA-2z8zA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ALA A 293
TYR A  40
LEU A 314
LEU A 345
SER A 346
 None
 1.35A 2nv4A-2z8zA:
undetectable		 2nv4A-2z8zA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ALA A 293
TYR A  40
LEU A 314
LEU A 345
SER A 346
 None
 1.36A 2nv4B-2z8zA:
undetectable		 2nv4B-2z8zA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 529
ALA A 531
GLY A 552
LEU A 512
LEU A 500
 CA  A 625 (-4.4A)
None
CA  A 627 ( 4.4A)
None
None
 1.03A 2nyuA-2z8zA:
undetectable		 2nyuA-2z8zA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.83A 2pxcA-2z8zA:
undetectable		 2pxcA-2z8zA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		3 / 3 ASP A 283
ASN A 284
THR A 334
 CA  A 619 ( 3.1A)
CA  A 618 (-3.3A)
None
 0.69A 2q63B-2z8zA:
undetectable		 2q63B-2z8zA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 5 ASN A 344
ALA A 317
GLY A 319
TYR A 318
 None
 0.92A 3bcrA-2z8zA:
undetectable		 3bcrA-2z8zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 ASN A 344
ALA A 317
GLY A 321
TYR A 318
 None
 1.13A 3ddsB-2z8zA:
undetectable		 3ddsB-2z8zA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 ASN A 344
ALA A 317
GLY A 321
TYR A 318
 None
 1.13A 3ddwB-2z8zA:
undetectable		 3ddwB-2z8zA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 SER A 368
THR A 369
GLY A 403
ILE A 444
VAL A 615
 None
None
CA  A 621 ( 4.7A)
None
None
 0.83A 3fzgA-2z8zA:
undetectable		 3fzgA-2z8zA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 1.01A 3gczA-2z8zA:
undetectable		 3gczA-2z8zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		3 / 3 GLU A 122
HIS A  30
THR A 108
 None
 0.87A 3hkuA-2z8zA:
undetectable		 3hkuA-2z8zA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ALA A 260
LEU A 163
ILE A 159
SER A 303
ALA A 172
 None
 1.37A 3lbdA-2z8zA:
undetectable		 3lbdA-2z8zA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.87A 3p97A-2z8zA:
undetectable		 3p97A-2z8zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.86A 3p97C-2z8zA:
undetectable		 3p97C-2z8zA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 LEU A 333
ASP A 337
VAL A   3
ILE A 285
ILE A 371
 None
CA  A 619 (-2.2A)
None
None
None
 0.97A 3so9B-2z8zA:
undetectable		 3so9B-2z8zA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 11 THR A 117
GLY A 111
THR A 143
GLY A 145
PRO A 146
 None
 1.31A 3t8nD-2z8zA:
undetectable
3t8nF-2z8zA:
undetectable		 3t8nD-2z8zA:
12.24
3t8nF-2z8zA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 11 THR A 143
GLY A 145
PRO A 146
THR A 117
GLY A 111
 None
 1.30A 3t8nD-2z8zA:
undetectable
3t8nF-2z8zA:
undetectable		 3t8nD-2z8zA:
12.24
3t8nF-2z8zA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 209
HIS A 206
ASN A 214
PRO A 239
LEU A 163
 None
 1.30A 3tm4A-2z8zA:
undetectable		 3tm4A-2z8zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 209
HIS A 206
ASN A 214
PRO A 239
LEU A 163
 None
 1.30A 3tm4B-2z8zA:
undetectable		 3tm4B-2z8zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 9 GLY A 539
GLY A 540
ASN A 562
GLY A 520
ASP A 525
 CA  A 626 ( 4.5A)
CA  A 626 (-4.2A)
CA  A 628 (-3.0A)
CA  A 626 ( 4.6A)
CA  A 624 ( 2.7A)
 1.10A 3ztvA-2z8zA:
undetectable		 3ztvA-2z8zA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
 None
 0.83A 4ax8A-2z8zA:
undetectable		 4ax8A-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
 None
 0.82A 4aztA-2z8zA:
undetectable		 4aztA-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
 None
 0.80A 4azvA-2z8zA:
undetectable		 4azvA-2z8zA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.85A 4ctjA-2z8zA:
undetectable		 4ctjA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.88A 4ctkA-2z8zA:
undetectable		 4ctkA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 7 PRO A 256
SER A 312
TRP A 310
HIS A 291
 None
 1.10A 4k7gB-2z8zA:
undetectable		 4k7gB-2z8zA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 4 ASP A  33
LEU A  32
ARG A 106
THR A 316
 None
 1.11A 4kjjA-2z8zA:
undetectable		 4kjjA-2z8zA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 11 GLY A 496
ALA A 531
GLY A 511
ILE A 614
LEU A 609
 CA  A 623 (-4.4A)
None
CA  A 623 (-4.2A)
None
None
 0.94A 4kt0A-2z8zA:
undetectable
4kt0J-2z8zA:
undetectable		 4kt0A-2z8zA:
23.45
4kt0J-2z8zA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.17A 4mm4A-2z8zA:
undetectable		 4mm4A-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.14A 4mm4B-2z8zA:
undetectable		 4mm4B-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.21A 4mm6A-2z8zA:
undetectable		 4mm6A-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 TYR A  40
GLY A 321
SER A 346
ASP A  33
THR A 316
 None
 1.21A 4mm8A-2z8zA:
undetectable		 4mm8A-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 11 ALA A 237
TYR A 236
SER A 204
GLY A 210
THR A 282
 None
 1.10A 4mmaA-2z8zA:
1.1		 4mmaA-2z8zA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 HIS A 517
VAL A 557
GLY A 541
ASP A 543
PHE A 527
 ZN  A 630 (-3.2A)
None
CA  A 626 (-4.5A)
CA  A 626 (-2.2A)
None
 1.39A 4mubA-2z8zA:
undetectable		 4mubA-2z8zA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ASN A 441
GLY A 403
ASN A 405
GLY A 382
ASP A 400
 None
CA  A 621 ( 4.7A)
CA  A 621 (-2.8A)
CA  A 621 ( 4.8A)
CA  A 621 (-2.3A)
 0.99A 4n09A-2z8zA:
undetectable		 4n09A-2z8zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ASN A 441
GLY A 403
ASN A 405
GLY A 382
ASP A 400
 None
CA  A 621 ( 4.7A)
CA  A 621 (-2.8A)
CA  A 621 ( 4.8A)
CA  A 621 (-2.3A)
 0.98A 4n09B-2z8zA:
undetectable		 4n09B-2z8zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ASN A 441
GLY A 403
ASN A 405
GLY A 382
ASP A 400
 None
CA  A 621 ( 4.7A)
CA  A 621 (-2.8A)
CA  A 621 ( 4.8A)
CA  A 621 (-2.3A)
 0.96A 4n09D-2z8zA:
undetectable		 4n09D-2z8zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		3 / 3 PRO A  50
LEU A  49
HIS A 313
 None
 0.72A 4pevA-2z8zA:
undetectable		 4pevA-2z8zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 THR A 282
SER A 280
ASP A 337
TYR A 252
GLY A 251
 None
None
CA  A 619 (-2.2A)
None
None
 1.48A 4qb9E-2z8zA:
1.9		 4qb9E-2z8zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 321
ALA A 317
ILE A 325
VAL A 342
ILE A 340
 None
 0.80A 4uw0A-2z8zA:
undetectable		 4uw0A-2z8zA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		3 / 3 GLU A 112
ILE A 138
ALA A 119
 None
 0.64A 4wnwB-2z8zA:
undetectable		 4wnwB-2z8zA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		3 / 3 ASP A 513
GLY A 532
ASP A 534
 None
CA  A 625 (-4.3A)
CA  A 625 ( 2.4A)
 0.61A 4xdtA-2z8zA:
undetectable		 4xdtA-2z8zA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 7 TYR A 331
LYS A   2
GLY A  10
SER A  14
 None
 1.21A 5bphB-2z8zA:
undetectable		 5bphB-2z8zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.86A 5e9qA-2z8zA:
undetectable		 5e9qA-2z8zA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.88A 5e9qC-2z8zA:
undetectable		 5e9qC-2z8zA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.88A 5ehgA-2z8zA:
undetectable		 5ehgA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.84A 5ehiA-2z8zA:
undetectable		 5ehiA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.96A 5ehiA-2z8zA:
undetectable		 5ehiA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.87A 5ehiC-2z8zA:
undetectable		 5ehiC-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.86A 5eifA-2z8zA:
undetectable		 5eifA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.87A 5eifC-2z8zA:
undetectable		 5eifC-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.88A 5eiwA-2z8zA:
undetectable		 5eiwA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.94A 5eiwA-2z8zA:
undetectable		 5eiwA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.86A 5ekxA-2z8zA:
undetectable		 5ekxA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 534
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 625 ( 2.4A)
None
 0.98A 5ekxA-2z8zA:
undetectable		 5ekxA-2z8zA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 VAL A  54
ASN A 344
ALA A 293
HIS A 291
ARG A 360
 None
 1.26A 5fhqA-2z8zA:
0.0		 5fhqA-2z8zA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 LEU A  97
GLN A  96
PHE A 190
LEU A 196
GLY A 137
 None
 1.44A 5i8fA-2z8zA:
undetectable		 5i8fA-2z8zA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.89A 5ikmA-2z8zA:
undetectable		 5ikmA-2z8zA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 THR A 103
GLU A 112
GLY A 111
ALA A 119
TYR A 175
 None
 1.16A 5kvaA-2z8zA:
undetectable		 5kvaA-2z8zA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 THR A 103
GLU A 112
GLY A 111
ALA A 119
TYR A 175
 None
 1.18A 5kvaB-2z8zA:
undetectable		 5kvaB-2z8zA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.89A 5njvA-2z8zA:
undetectable		 5njvA-2z8zA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 GLY A 505
GLY A 520
GLY A 523
ASP A 516
ASP A 507
 None
CA  A 626 ( 4.6A)
CA  A 624 ( 3.3A)
CA  A 623 ( 2.3A)
None
 0.88A 5njvB-2z8zA:
undetectable		 5njvB-2z8zA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 LEU A 568
GLY A 443
GLY A 403
GLY A 383
TYR A 388
 None
None
CA  A 621 ( 4.7A)
CA  A 621 (-4.4A)
None
 1.12A 6ce2B-2z8zA:
undetectable		 6ce2B-2z8zA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		4 / 6 TYR A 292
ASP A 275
VAL A 273
GLU A 253
 None
CA  A 618 (-2.2A)
None
CA  A 618 (-3.3A)
 1.11A 6djzB-2z8zA:
undetectable		 6djzB-2z8zA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 LEU A 389
GLY A 409
ASP A 375
ILE A 371
ILE A 380
 None
CA  A 622 (-4.6A)
None
None
None
 1.01A 6emuA-2z8zA:
undetectable		 6emuA-2z8zA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2z8z LIPASE
(Pseudomonas
sp.
MIS38) 		5 / 12 ILE A 138
LEU A  17
GLY A 205
PHE A 140
ILE A  24
 None
 1.45A 6qyaB-2z8zA:
undetectable		 6qyaB-2z8zA:
20.67