SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 8 LEU A 178
SER A 128
PHE A 131
GLY A 132
 NDP  A1001 (-4.9A)
None
None
None
 0.73A 1fapB-2z95A:
undetectable		 1fapB-2z95A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 8 VAL A  90
SER A  91
ASP A 102
LYS A 155
 None
None
None
NDP  A1001 (-2.9A)
 1.21A 1hwiB-2z95A:
undetectable		 1hwiB-2z95A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 8 VAL A  90
SER A  91
ASP A 102
LYS A 155
 None
None
None
NDP  A1001 (-2.9A)
 1.22A 1hwkA-2z95A:
undetectable		 1hwkA-2z95A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 8 VAL A  90
SER A  91
ASP A 102
LYS A 155
 None
None
None
NDP  A1001 (-2.9A)
 1.21A 1hwkC-2z95A:
undetectable		 1hwkC-2z95A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 8 VAL A  90
SER A  91
ASP A 102
LYS A 155
 None
None
None
NDP  A1001 (-2.9A)
 1.22A 1hwkD-2z95A:
undetectable		 1hwkD-2z95A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		3 / 3 GLU A 229
TRP A 232
LYS A 336
 None
 1.37A 1qu2A-2z95A:
1.9		 1qu2A-2z95A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 12 GLY A  16
GLY A  32
ALA A  33
LEU A  22
LEU A  23
 None
 0.94A 2nyuA-2z95A:
7.6		 2nyuA-2z95A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 7 ALA A 224
TYR A  18
TYR A 223
MET A 330
 None
 1.37A 2pncA-2z95A:
undetectable		 2pncA-2z95A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 10 PHE A 145
GLU A 141
ILE A 177
ASP A 220
GLY A 306
 None
 1.49A 2tsrC-2z95A:
undetectable		 2tsrC-2z95A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 11 ILE A   8
ALA A   6
PHE A 122
THR A  70
ILE A  67
 None
 1.23A 2w3aA-2z95A:
undetectable		 2w3aA-2z95A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		6 / 10 ILE A   8
ALA A   6
PHE A 122
THR A  70
ILE A  67
LEU A  61
 None
None
None
None
None
NDP  A1001 (-3.5A)
 1.32A 2w3aB-2z95A:
undetectable		 2w3aB-2z95A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 8 SER A 183
LEU A 185
TYR A 223
LEU A  48
 None
 0.90A 3i45A-2z95A:
2.4		 3i45A-2z95A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 11 ALA A   6
VAL A  54
GLY A  32
ALA A  33
LEU A  24
 None
 0.83A 3sm2B-2z95A:
undetectable		 3sm2B-2z95A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 7 ILE A   8
LEU A  82
GLY A  13
GLY A  16
 None
NDP  A1001 (-4.2A)
NDP  A1001 (-3.4A)
None
 0.86A 5a06A-2z95A:
7.1		 5a06A-2z95A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 7 ILE A   8
LEU A  82
GLY A  13
GLY A  16
 None
NDP  A1001 (-4.2A)
NDP  A1001 (-3.4A)
None
 0.85A 5a06B-2z95A:
7.1		 5a06B-2z95A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 7 ILE A   8
LEU A  82
GLY A  13
GLY A  16
 None
NDP  A1001 (-4.2A)
NDP  A1001 (-3.4A)
None
 0.85A 5a06E-2z95A:
7.2		 5a06E-2z95A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 12 ILE A 202
VAL A 257
GLY A 265
MET A 331
LEU A 335
 None
 0.99A 5byjA-2z95A:
1.7		 5byjA-2z95A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 5 PHE A 266
GLY A 205
ASP A 281
ILE A 288
 None
 0.98A 5ik1A-2z95A:
undetectable		 5ik1A-2z95A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 12 ILE A 288
LEU A 199
GLU A 269
ARG A 254
GLY A 279
 None
 1.23A 5il1A-2z95A:
undetectable		 5il1A-2z95A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2z95 GDP-D-MANNOSE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 12 ILE A 288
LEU A 199
GLU A 269
ARG A 254
GLY A 279
 None
 1.35A 5k7uA-2z95A:
undetectable		 5k7uA-2z95A:
21.73