SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_D_THAD4_2 (LIVER CARBOXYLESTERASE I)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	3 / 3	PHE A 173 LEU A 118 MET A 144	None	0.90A	1mx1D-2z99A: undetectable	1mx1D-2z99A: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XDK_B_9CRB600_2 (RETINOIC ACID RECEPTOR, BETA)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	3 / 3	LEU A 152 PHE A 173 ARG A 124	None	0.87A	1xdkB-2z99A: undetectable	1xdkB-2z99A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYX_A_ROCA201_2 (HIV-1 PROTEASE)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	3 / 3	ARG A 150 VAL A 140 THR A 117	None	0.79A	3cyxA-2z99A: undetectable	3cyxA-2z99A: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYX_A_ROCA201_4 (HIV-1 PROTEASE)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	4 / 4	LEU A 63 ASP A 26 VAL A 31 THR A 52	None	1.28A	3cyxB-2z99A: undetectable	3cyxB-2z99A: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WAR_A_NIOA401_1 (CASEIN KINASE II SUBUNIT ALPHA)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	4 / 8	VAL A 132 VAL A 127 PHE A 167 ILE A 153	None	0.74A	3warA-2z99A: undetectable	3warA-2z99A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_B_NIOB401_1 (CASEIN KINASE II SUBUNIT ALPHA')	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	4 / 7	VAL A 132 VAL A 127 PHE A 167 ILE A 153	None	0.84A	5yf9B-2z99A: undetectable	5yf9B-2z99A: 16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNR_A_6J3A201_0 (TRANSTHYRETIN)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	4 / 4	LYS A 62 LEU A 32 ALA A 60 LEU A 48	None	1.46A	6gnrA-2z99A: undetectable	6gnrA-2z99A: 21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GNR_B_6J3B201_0 (TRANSTHYRETIN)	2z99	PUTATIVE UNCHARACTERIZED PROTEIN (Mycobacterium tuberculosis)	4 / 4	LYS A 62 LEU A 32 ALA A 60 LEU A 48	None	1.45A	6gnrB-2z99A: undetectable	6gnrB-2z99A: 21.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MX1_D_THAD4_2","LIVER CARBOXYLESTERASE I","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",3,"PHE A 173;LEU A 118;MET A 144","None","0.90A","1mx1D-2z99A:undetectable","1mx1D-2z99A:18.67"],["1XDK_B_9CRB600_2","RETINOIC ACID RECEPTOR, BETA","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",3,"LEU A 152;PHE A 173;ARG A 124","None","0.87A","1xdkB-2z99A:undetectable","1xdkB-2z99A:20.00"],["3CYX_A_ROCA201_2","HIV-1 PROTEASE","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",3,"ARG A 150;VAL A 140;THR A 117","None","0.79A","3cyxA-2z99A:undetectable","3cyxA-2z99A:19.16"],["3CYX_A_ROCA201_4","HIV-1 PROTEASE;HIV-1 PROTEASE","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",4,"LEU A  63;ASP A  26;VAL A  31;THR A  52","None","1.28A","3cyxB-2z99A:undetectable","3cyxB-2z99A:19.16"],["3WAR_A_NIOA401_1","CASEIN KINASE II SUBUNIT ALPHA","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",4,"VAL A 132;VAL A 127;PHE A 167;ILE A 153","None","0.74A","3warA-2z99A:undetectable","3warA-2z99A:20.17"],["5YF9_B_NIOB401_1","CASEIN KINASE II SUBUNIT ALPHA'","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",4,"VAL A 132;VAL A 127;PHE A 167;ILE A 153","None","0.84A","5yf9B-2z99A:undetectable","5yf9B-2z99A:16.13"],["6GNR_A_6J3A201_0","TRANSTHYRETIN","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",4,"LYS A  62;LEU A  32;ALA A  60;LEU A  48","None","1.46A","6gnrA-2z99A:undetectable","6gnrA-2z99A:21.17"],["6GNR_B_6J3B201_0","TRANSTHYRETIN","2z99","PUTATIVE UNCHARACTERIZED PROTEIN","Mycobacterium tuberculosis",4,"LYS A  62;LEU A  32;ALA A  60;LEU A  48","None","1.45A","6gnrB-2z99A:undetectable","6gnrB-2z99A:21.17"]]