SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z9v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 8 LEU A  90
VAL A 161
GLY A 158
LEU A  88
 None
 0.86A 1jlbA-2z9vA:
2.3		 1jlbA-2z9vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 8 LEU A  90
VAL A 161
GLY A 158
LEU A  88
 None
 0.88A 1s1xA-2z9vA:
2.5		 1s1xA-2z9vA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 5 LEU A 362
PRO A 355
ALA A 358
ILE A 359
 None
 0.91A 2aofB-2z9vA:
undetectable		 2aofB-2z9vA:
13.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		10 / 11 GLU A  68
PRO A  69
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
ASN A 196
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
None
 0.38A 2z9wA-2z9vA:
70.8		 2z9wA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		6 / 11 TYR A  95
CYH A 142
THR A 146
SER A 174
ASN A 196
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 ( 3.7A)
None
SO4  A1601 (-2.7A)
 0.77A 2z9wA-2z9vA:
70.8		 2z9wA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		10 / 11 GLU A  68
PRO A  69
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
ASN A 196
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
None
 0.38A 2z9wB-2z9vA:
69.7		 2z9wB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		8 / 11 GLU A  68
PRO A  69
TYR A  95
CYH A 142
THR A 146
SER A 174
ASN A 196
LYS A 197
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 ( 3.7A)
None
SO4  A1601 (-2.7A)
 0.71A 2z9wB-2z9vA:
69.7		 2z9wB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		9 / 10 GLU A  68
PRO A  69
VAL A  70
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 (-4.1A)
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
 0.24A 2z9xA-2z9vA:
70.2		 2z9xA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		5 / 10 TYR A  95
CYH A 142
ASP A 171
SER A 174
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 3.7A)
SO4  A1601 (-2.7A)
 1.01A 2z9xA-2z9vA:
70.2		 2z9xA-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		10 / 11 GLU A  68
PRO A  69
VAL A  70
LEU A  73
TYR A  95
CYH A 142
THR A 146
ASP A 171
VAL A 173
SER A 174
 PXM  A1501 (-3.2A)
PXM  A1501 (-3.8A)
PXM  A1501 (-4.1A)
None
PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 ( 3.3A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 4.4A)
PXM  A1501 ( 3.7A)
 0.31A 2z9xB-2z9vA:
69.1		 2z9xB-2z9vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		5 / 11 TYR A  95
CYH A 142
ASP A 171
SER A 174
LYS A 197
 PXM  A1501 ( 3.6A)
PXM  A1501 ( 3.8A)
PXM  A1501 (-2.7A)
PXM  A1501 ( 3.7A)
SO4  A1601 (-2.7A)
 1.02A 2z9xB-2z9vA:
69.1		 2z9xB-2z9vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		3 / 3 LYS A  61
LYS A  47
VAL A  49
 None
 1.05A 3brfA-2z9vA:
undetectable		 3brfA-2z9vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		5 / 12 GLU A 112
GLY A  98
GLY A  93
ALA A  91
GLY A 100
 None
GOL  A 955 (-3.6A)
None
None
None
 1.06A 3tegA-2z9vA:
2.4		 3tegA-2z9vA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		3 / 3 LYS A  51
ARG A  31
LEU A  44
 None
 1.43A 3v4tE-2z9vA:
undetectable		 3v4tE-2z9vA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 6 GLY A 200
PRO A 202
GLY A 204
GLU A  68
 None
None
None
PXM  A1501 (-3.2A)
 0.86A 4dxuA-2z9vA:
undetectable		 4dxuA-2z9vA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		3 / 3 PHE A  99
VAL A 126
ILE A 121
 None
 0.54A 4emaA-2z9vA:
undetectable		 4emaA-2z9vA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 7 LEU A  14
THR A 344
THR A 307
VAL A 309
 None
 0.90A 4ik7A-2z9vA:
undetectable		 4ik7A-2z9vA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		3 / 3 LYS A  54
ARG A  57
HIS A 182
 None
 1.20A 4zbrA-2z9vA:
undetectable		 4zbrA-2z9vA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		6 / 12 LEU A 261
ALA A  55
GLU A 270
GLY A 194
PRO A 195
GLY A 178
 None
 1.46A 5vcvA-2z9vA:
undetectable		 5vcvA-2z9vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2z9v ASPARTATE
AMINOTRANSFERASE
(Mesorhizobium
loti) 		4 / 6 LEU A 292
LEU A 320
THR A 363
ARG A   3
 None
 1.10A 6ew0G-2z9vA:
undetectable		 6ew0G-2z9vA:
12.54