SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2za1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 LEU A 222
PHE A 239
TYR A 251
VAL A 190
 None
 1.23A 1ibgH-2za1A:
undetectable		 1ibgH-2za1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 8 THR A 163
PHE A 239
MET A 217
LEU A 173
 OMP  A 500 ( 4.2A)
None
None
None
 1.09A 1lhvA-2za1A:
undetectable		 1lhvA-2za1A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		3 / 3 LYS A 193
ILE A 261
THR A 163
 None
None
OMP  A 500 ( 4.2A)
 0.65A 1rx3A-2za1A:
undetectable		 1rx3A-2za1A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		5 / 12 MET A 172
ILE A 139
VAL A 146
CYH A 162
LEU A 191
 None
 1.28A 1wsvB-2za1A:
undetectable		 1wsvB-2za1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 LEU A  18
TYR A 309
ILE A 296
GLY A 265
 None
 0.92A 2du8A-2za1A:
undetectable		 2du8A-2za1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 LEU A  18
TYR A 309
ILE A 296
GLY A 265
 None
 0.92A 2du8B-2za1A:
undetectable		 2du8B-2za1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 7 ASP A  25
PHE A 107
PRO A  24
THR A 297
 None
 1.38A 2q6kA-2za1A:
undetectable		 2q6kA-2za1A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 ASP A  25
PHE A 107
PRO A  24
THR A 297
 None
 1.45A 2q6oB-2za1A:
undetectable		 2q6oB-2za1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		5 / 11 PHE A 236
SER A 187
ILE A 134
PHE A 189
VAL A   5
 None
 1.15A 3a9eB-2za1A:
undetectable		 3a9eB-2za1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 5 PHE A  79
ILE A  62
MET A  33
ASN A  31
 None
 1.37A 3octA-2za1A:
undetectable		 3octA-2za1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 7 LEU A 191
GLY A 238
ALA A 188
PHE A 236
 None
 0.97A 3tehB-2za1A:
undetectable		 3tehB-2za1A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		5 / 9 LEU A   7
ILE A 316
LEU A 273
ILE A 266
ILE A 292
 None
 1.18A 3zosB-2za1A:
undetectable		 3zosB-2za1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		3 / 3 LYS A 193
ILE A 261
THR A 163
 None
None
OMP  A 500 ( 4.2A)
 0.65A 4gh8A-2za1A:
undetectable		 4gh8A-2za1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 4 ILE A 139
ASN A 140
ILE A 166
VAL A 190
 None
 1.31A 4uy87-2za1A:
undetectable		 4uy87-2za1A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.16A 4w5qA-2za1A:
undetectable		 4w5qA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.21A 4w5tA-2za1A:
undetectable		 4w5tA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.20A 4z4dA-2za1A:
undetectable		 4z4dA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 7 ILE A 296
GLY A 293
PHE A  88
ASP A  28
 None
OMP  A 500 (-3.6A)
None
None
 1.01A 5hieA-2za1A:
undetectable		 5hieA-2za1A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		3 / 3 ASN A  15
TYR A 310
CYH A  17
 None
 0.81A 5lsuB-2za1A:
undetectable		 5lsuB-2za1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Plasmodium
falciparum) 		4 / 6 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.16A 6cbdA-2za1A:
undetectable		 6cbdA-2za1A:
14.80