SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 7 SER A 143
PHE A 284
ARG A 146
GLN A 286
 None
LGU  A 403 ( 3.8A)
LGU  A 403 (-3.1A)
None
 1.30A 2c8aA-2zabA:
undetectable		 2c8aA-2zabA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 5 LEU A 237
ALA A 295
ASN A 283
ILE A 185
 None
 1.16A 4y03B-2zabA:
undetectable		 4y03B-2zabA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 8 ILE A 245
LYS A 205
VAL A 254
GLN A 216
 None
 0.92A 5dqyA-2zabA:
undetectable		 5dqyA-2zabA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		5 / 9 PHE A  89
THR A 122
PRO A  85
TYR A 115
LEU A 111
 GOL  A 601 ( 4.6A)
None
None
None
None
 1.49A 5j2tB-2zabA:
0.0		 5j2tB-2zabA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 8 THR A 169
SER A 305
THR A 167
SER A 307
 None
 0.73A 5l4eA-2zabA:
undetectable
5l4eB-2zabA:
undetectable
5l4eC-2zabA:
undetectable
5l4eD-2zabA:
undetectable
5l4eE-2zabA:
undetectable		 5l4eA-2zabA:
19.88
5l4eB-2zabA:
19.88
5l4eC-2zabA:
19.88
5l4eD-2zabA:
19.88
5l4eE-2zabA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2zab ALGINATE LYASE
(Sphingomonas
sp.
A1) 		4 / 7 HIS A 306
ARG A 150
HIS A 191
GLU A 151
 None
LGU  A 401 (-3.8A)
LGU  A 403 (-3.7A)
None
 1.31A 6mn4F-2zabA:
undetectable		 6mn4F-2zabA:
22.76