SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zae'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
5 / 8 ARG A 111
LEU A 112
VAL A  70
LEU A  51
VAL A  38
None
1.38A 2bdmA-2zaeA:
undetectable
2bdmA-2zaeA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
4 / 5 ILE A  94
SER A  93
PHE A  63
PRO A  89
None
None
GOL  A 132 ( 4.5A)
NO3  A 130 ( 4.6A)
1.17A 3bjwC-2zaeA:
undetectable
3bjwC-2zaeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
4 / 8 PHE A  63
HIS A  60
MET A  77
ILE A  80
GOL  A 132 ( 4.5A)
GOL  A 132 ( 4.4A)
None
None
1.34A 4cx7A-2zaeA:
undetectable
4cx7B-2zaeA:
undetectable
4cx7A-2zaeA:
15.21
4cx7B-2zaeA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
4 / 7 LEU A  78
ARG A 119
ILE A  43
GLY A 109
None
0.94A 4eq4A-2zaeA:
undetectable
4eq4A-2zaeA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
4 / 7 LEU A  78
ARG A 119
ILE A  43
GLY A 109
None
0.93A 4eqlA-2zaeA:
undetectable
4eqlA-2zaeA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
4 / 7 LEU A  78
ARG A 119
ILE A  43
GLY A 109
None
0.95A 4eqlB-2zaeA:
undetectable
4eqlB-2zaeA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
4 / 6 LEU A  78
ARG A 119
ILE A  43
GLY A 109
None
0.93A 4l39A-2zaeA:
undetectable
4l39A-2zaeA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)
2zae RIBONUCLEASE P
PROTEIN COMPONENT 1

(Pyrococcus
horikoshii)
5 / 12 LEU A 112
ILE A  43
ARG A  40
VAL A  70
HIS A  34
None
1.28A 5h1eA-2zaeA:
0.0
5h1eA-2zaeA:
18.70