SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 720
PRO A 712
GLU A 715
PHE A 707
 None
 1.40A 1oniA-2zaiA:
undetectable
1oniC-2zaiA:
undetectable		 1oniA-2zaiA:
16.27
1oniC-2zaiA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 SER A 876
GLY A 877
ARG A 588
 None
 0.64A 1t9wA-2zaiA:
undetectable		 1t9wA-2zaiA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ALA A 786
ILE A 799
ILE A 732
LEU A 746
ILE A 771
 None
 1.02A 3clbA-2zaiA:
undetectable		 3clbA-2zaiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 ALA A 786
ILE A 799
ILE A 732
LEU A 746
ILE A 771
 None
 1.04A 3hbbA-2zaiA:
undetectable		 3hbbA-2zaiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 GLU A 843
LEU A 918
ILE A 896
PHE A 869
ASP A 928
 None
 1.48A 3ko0C-2zaiA:
undetectable
3ko0D-2zaiA:
undetectable
3ko0E-2zaiA:
undetectable
3ko0F-2zaiA:
undetectable		 3ko0C-2zaiA:
10.47
3ko0D-2zaiA:
10.47
3ko0E-2zaiA:
10.47
3ko0F-2zaiA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ASP A 928
PHE A 869
LEU A 918
ILE A 896
GLU A 843
 None
 1.44A 3ko0C-2zaiA:
undetectable
3ko0D-2zaiA:
undetectable
3ko0E-2zaiA:
undetectable
3ko0F-2zaiA:
undetectable		 3ko0C-2zaiA:
10.47
3ko0D-2zaiA:
10.47
3ko0E-2zaiA:
10.47
3ko0F-2zaiA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ASP A 763
LEU A 815
ILE A 757
PHE A 724
ASP A 556
 None
 0.95A 3ko0G-2zaiA:
undetectable
3ko0H-2zaiA:
undetectable
3ko0I-2zaiA:
undetectable
3ko0J-2zaiA:
undetectable		 3ko0G-2zaiA:
10.47
3ko0H-2zaiA:
10.47
3ko0I-2zaiA:
10.47
3ko0J-2zaiA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LEU A 918
ILE A 896
GLU A 843
PHE A 869
ASP A 928
 None
 1.45A 3ko0O-2zaiA:
undetectable
3ko0P-2zaiA:
undetectable
3ko0Q-2zaiA:
undetectable
3ko0R-2zaiA:
undetectable		 3ko0O-2zaiA:
10.47
3ko0P-2zaiA:
10.47
3ko0Q-2zaiA:
10.47
3ko0R-2zaiA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 ASP A 928
PHE A 869
GLU A 843
LEU A 918
ILE A 896
 None
 1.43A 3ko0Q-2zaiA:
undetectable
3ko0R-2zaiA:
undetectable
3ko0S-2zaiA:
undetectable
3ko0T-2zaiA:
undetectable		 3ko0Q-2zaiA:
10.47
3ko0R-2zaiA:
10.47
3ko0S-2zaiA:
10.47
3ko0T-2zaiA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 ARG A 941
ILE A 870
LEU A 930
ARG A 874
GLY A 935
 None
 1.45A 3nxuB-2zaiA:
undetectable		 3nxuB-2zaiA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 TRP A 511
GLY A 582
ALA A 547
PHE A 565
 None
 1.29A 3wqwA-2zaiA:
undetectable		 3wqwA-2zaiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLN A 817
ILE A 764
GLY A 761
ASN A 709
 None
 0.99A 4fgjA-2zaiA:
undetectable
4fgjB-2zaiA:
undetectable		 4fgjA-2zaiA:
18.11
4fgjB-2zaiA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 PHE A 727
TYR A 955
THR A 768
ILE A 764
 None
 1.00A 4jx1E-2zaiA:
undetectable		 4jx1E-2zaiA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 LEU A 865
ILE A 870
MET A 891
TRP A 560
 None
 1.37A 5ljeA-2zaiA:
undetectable		 5ljeA-2zaiA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 GLU A 952
PHE A 727
TYR A 955
ARG A 762
 None
None
None
CL  A   5 (-3.6A)
 1.39A 5oajD-2zaiA:
0.0
5oajE-2zaiA:
0.0		 5oajD-2zaiA:
18.31
5oajE-2zaiA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 4 SER A 628
THR A 632
ASP A 635
ASP A 639
 None
 1.42A 5vimA-2zaiA:
undetectable		 5vimA-2zaiA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 4 SER A 628
THR A 632
ASP A 635
ASP A 639
 None
 1.39A 5vimB-2zaiA:
undetectable		 5vimB-2zaiA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 PHE A 565
PHE A 710
LEU A 706
PHE A 702
 None
 1.35A 5wauC-2zaiA:
undetectable
5wauJ-2zaiA:
undetectable		 5wauC-2zaiA:
17.76
5wauJ-2zaiA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 PHE A 565
PHE A 710
LEU A 706
PHE A 702
 None
 1.35A 5wauc-2zaiA:
undetectable
5wauj-2zaiA:
undetectable		 5wauc-2zaiA:
17.76
5wauj-2zaiA:
8.05