SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zal'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 10 ALA A   7
SER A  48
LEU B 191
ALA B 192
ILE B 280
 None
 1.08A 1g5yC-2zalA:
undetectable		 1g5yC-2zalA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		4 / 7 SER B 211
GLY B 275
THR B 292
ILE A  15
 ASP  B 501 ( 3.8A)
None
None
None
 1.06A 2bdmA-2zalB:
undetectable		 2bdmA-2zalB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 ILE A  15
GLY B 276
THR B 230
HIS A   9
GLY A  13
 None
None
ASP  B 501 ( 3.8A)
None
None
 1.18A 2fn1A-2zalA:
undetectable		 2fn1A-2zalA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 ILE A  15
GLY B 276
THR B 230
HIS A   9
GLY A  13
 None
None
ASP  B 501 ( 3.8A)
None
None
 1.20A 2fn1B-2zalA:
undetectable		 2fn1B-2zalA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 12 GLY B 276
GLY B 233
GLY B 231
LEU B 268
LEU B 213
 None
ASP  B 501 ( 3.0A)
ASP  B 501 ( 3.8A)
None
None
 0.95A 2nxeB-2zalB:
undetectable		 2nxeB-2zalB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 ALA B 216
ALA B 241
GLY B 231
GLY B 209
ILE B 237
 None
None
ASP  B 501 ( 3.8A)
ASP  B 501 ( 4.0A)
None
 1.11A 2x1lA-2zalB:
undetectable		 2x1lA-2zalB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 ALA B 216
ALA B 241
GLY B 231
GLY B 209
ILE B 237
 None
None
ASP  B 501 ( 3.8A)
ASP  B 501 ( 4.0A)
None
 1.07A 2x1lC-2zalB:
undetectable		 2x1lC-2zalB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		4 / 4 GLY A  39
VAL A  52
GLY B 181
THR B 195
 None
 0.85A 3ib2A-2zalA:
undetectable		 3ib2A-2zalA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 LEU A  60
ILE A   8
ALA A  34
ALA B 298
THR B 308
 None
 1.05A 3mdtB-2zalA:
undetectable		 3mdtB-2zalA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 THR B 230
THR B 195
ALA A  84
GLY A  10
SER B 228
 ASP  B 501 ( 3.8A)
None
None
None
None
 1.18A 3mg0N-2zalB:
5.2		 3mg0N-2zalB:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 12 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A 800 ( 4.4A)
None
None
 1.18A 3qxyA-2zalA:
undetectable		 3qxyA-2zalA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A 800 ( 4.4A)
None
None
 1.16A 3qxyB-2zalA:
undetectable
3qxyQ-2zalA:
undetectable		 3qxyB-2zalA:
16.83
3qxyQ-2zalA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 11 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A 800 ( 4.4A)
None
None
 1.18A 3rc0A-2zalA:
undetectable		 3rc0A-2zalA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 12 VAL A  73
ALA A  72
GLY A  71
ALA A  84
ASN A  67
 None
None
NA  A 800 ( 4.4A)
None
None
 1.16A 3rc0B-2zalA:
undetectable		 3rc0B-2zalA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 12 VAL A 113
GLY B 181
ALA B 194
ARG A 111
THR A  54
 None
 1.05A 3sugA-2zalA:
undetectable		 3sugA-2zalA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		4 / 8 ASN B 221
ALA B 223
SER B 224
TYR B 251
 None
 1.02A 4ijiF-2zalB:
undetectable		 4ijiF-2zalB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		4 / 6 TYR A  28
ARG A 149
GLY A  71
LEU A 148
 None
None
NA  A 800 ( 4.4A)
None
 1.04A 5bphA-2zalA:
undetectable		 5bphA-2zalA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 2zal L-ASPARAGINASE
L-ASPARAGINASE
(Escherichia
coli;
Escherichia
coli) 		3 / 3 ARG B 207
THR B 197
ASP A  83
 ASP  B 501 ( 2.8A)
ASP  B 501 ( 3.9A)
None
 0.94A 5g5gA-2zalB:
undetectable
5g5gB-2zalB:
undetectable		 5g5gA-2zalB:
20.52
5g5gB-2zalB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 12 VAL B 214
ALA A  96
MET A 121
VAL A 120
GLY A  99
 None
 1.25A 5igiA-2zalB:
undetectable		 5igiA-2zalB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 10 ALA B 194
THR B 195
ALA A  94
GLY A  95
ALA A 110
 None
 1.19A 5lf3H-2zalB:
5.3
5lf3I-2zalB:
4.6		 5lf3H-2zalB:
25.36
5lf3I-2zalB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		5 / 10 ALA B 194
THR B 195
ALA A  94
GLY A  95
ALA A 110
 None
 1.20A 5lf3V-2zalB:
3.7
5lf3W-2zalB:
4.6		 5lf3V-2zalB:
25.36
5lf3W-2zalB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2zal L-ASPARAGINASE
(Escherichia
coli) 		4 / 8 LYS B 179
PHE B 236
THR B 197
GLY B 276
 None
None
ASP  B 501 ( 3.9A)
None
 0.96A 5v0vA-2zalB:
undetectable		 5v0vA-2zalB:
13.77