SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		5 / 10 THR A 322
ASN A 319
ASP A 325
VAL A 409
MET A 414
 None
 1.46A 1ivvA-2zamA:
undetectable		 1ivvA-2zamA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		5 / 10 THR A 322
ASN A 319
ASP A 325
VAL A 409
MET A 414
 None
 1.45A 1ivvB-2zamA:
undetectable		 1ivvB-2zamA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		4 / 6 ILE A 124
VAL A 125
ILE A 298
ASP A 234
 None
 0.85A 1uwhB-2zamA:
undetectable		 1uwhB-2zamA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		3 / 3 LYS A 180
ASP A 429
ASN A 279
 None
 0.98A 2bm9A-2zamA:
undetectable		 2bm9A-2zamA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		5 / 12 LEU A 183
LEU A 146
VAL A 150
ILE A 230
PHE A 196
 None
 1.22A 2weyA-2zamA:
undetectable		 2weyA-2zamA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		4 / 8 LEU A 172
VAL A 150
ILE A 230
PHE A 196
 None
 0.96A 2weyB-2zamA:
undetectable		 2weyB-2zamA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		4 / 8 LEU A 183
VAL A 150
ILE A 230
PHE A 196
 None
 0.94A 2weyB-2zamA:
undetectable		 2weyB-2zamA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2zam VACUOLAR PROTEIN
SORTING-ASSOCIATING
PROTEIN 4B
(Mus
musculus) 		5 / 12 ILE A 344
PHE A 310
ARG A 311
LEU A 314
SER A 417
 None
 1.16A 3k2hB-2zamA:
undetectable		 3k2hB-2zamA:
21.32