SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zat'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 SER A 151
VAL A 152
GLY A 153
GLY A 195
SER A 218
 NAP  A1261 ( 3.4A)
None
None
None
None
 1.09A 1fduA-2zatA:
26.6		 1fduA-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 SER A 151
VAL A 152
GLY A 153
TYR A 164
GLY A 195
 NAP  A1261 ( 3.4A)
None
None
NAP  A1261 ( 4.6A)
None
 0.65A 1fduA-2zatA:
26.6		 1fduA-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 SER A 151
VAL A 152
GLY A 153
GLY A 195
SER A 218
 NAP  A1261 ( 3.4A)
None
None
None
None
 0.87A 1fduC-2zatA:
26.6		 1fduC-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 SER A 151
VAL A 152
GLY A 153
TYR A 164
GLY A 195
 NAP  A1261 ( 3.4A)
None
None
NAP  A1261 ( 4.6A)
None
 0.63A 1fduC-2zatA:
26.6		 1fduC-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 11 SER A 151
VAL A 152
GLY A 153
TYR A 164
GLY A 195
 NAP  A1261 ( 3.4A)
None
None
NAP  A1261 ( 4.6A)
None
 0.53A 1iolA-2zatA:
27.4		 1iolA-2zatA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 GLN A  59
GLY A  62
ALA A  31
ILE A  94
HIS A  89
 None
 1.26A 1kxhA-2zatA:
undetectable		 1kxhA-2zatA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		4 / 6 ALA A 231
LEU A  28
GLU A 228
LEU A  63
 None
 0.77A 1mt1D-2zatA:
undetectable
1mt1E-2zatA:
undetectable		 1mt1D-2zatA:
16.41
1mt1E-2zatA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		3 / 3 LYS A  10
PRO A  11
LEU A  12
 None
 0.72A 3tpxE-2zatA:
undetectable		 3tpxE-2zatA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		4 / 5 SER A 151
ILE A  26
TYR A 164
GLY A 195
 NAP  A1261 ( 3.4A)
NAP  A1261 ( 3.7A)
NAP  A1261 ( 4.6A)
None
 1.04A 3uboB-2zatA:
7.1		 3uboB-2zatA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 11 ILE A  30
ILE A  26
GLY A  25
VAL A 252
GLY A 225
 None
NAP  A1261 ( 3.7A)
NAP  A1261 ( 3.0A)
None
None
 1.01A 4ac9B-2zatA:
6.7
4ac9C-2zatA:
6.4		 4ac9B-2zatA:
18.88
4ac9C-2zatA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		4 / 7 GLY A 153
SER A 202
THR A 199
PHE A 201
 None
NAP  A1261 ( 3.4A)
NAP  A1261 ( 2.7A)
NAP  A1261 ( 4.9A)
 0.61A 4ac9C-2zatA:
6.4		 4ac9C-2zatA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		3 / 3 ARG A 185
TYR A 244
ASN A 190
 None
 0.93A 4ffwB-2zatA:
undetectable		 4ffwB-2zatA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 GLY A 143
GLY A 142
LEU A 147
ASP A  93
LEU A  34
 None
 1.04A 4fp9A-2zatA:
6.5		 4fp9A-2zatA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 GLY A 143
GLY A 142
LEU A 147
ASP A  93
LEU A  34
 None
 1.05A 4fp9C-2zatA:
7.1		 4fp9C-2zatA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 12 GLY A 143
GLY A 142
LEU A 147
ASP A  93
LEU A  34
 None
 1.04A 4fp9F-2zatA:
6.5		 4fp9F-2zatA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		5 / 8 SER A 151
LEU A 174
LEU A 171
SER A 150
THR A 249
 NAP  A1261 ( 3.4A)
None
None
None
None
 1.33A 4ikjA-2zatA:
undetectable
4ikjB-2zatA:
undetectable		 4ikjA-2zatA:
19.54
4ikjB-2zatA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		3 / 3 HIS A  71
SER A  97
ASN A 123
 NAP  A1261 ( 3.6A)
None
None
 0.92A 5cprB-2zatA:
undetectable		 5cprB-2zatA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		3 / 3 LYS A 125
LEU A 129
ARG A  78
 None
 0.93A 5yw0A-2zatA:
undetectable		 5yw0A-2zatA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Sus
scrofa) 		3 / 3 LEU A 237
SER A 235
PHE A 236
 None
 0.65A 6fgcA-2zatA:
2.3		 6fgcA-2zatA:
22.59