SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RHM_D_BEZD194_0 (PUTATIVE KINASE)	2zay	RESPONSE REGULATOR RECEIVER PROTEIN (Desulfuromonas acetoxidans)	4 / 5	ILE A 109 ARG A 117 ARG A 121 ASP A 107	None	1.27A	2rhmD-2zayA: 3.4	2rhmD-2zayA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WX2_B_TPFB1460_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	2zay	RESPONSE REGULATOR RECEIVER PROTEIN (Desulfuromonas acetoxidans)	4 / 8	MET A 103 PHE A 105 ALA A 87 ALA A 60	None	0.96A	2wx2B-2zayA: undetectable	2wx2B-2zayA: 14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V5W_A_8PRA701_2 (G-PROTEIN COUPLED RECEPTOR KINASE 2)	2zay	RESPONSE REGULATOR RECEIVER PROTEIN (Desulfuromonas acetoxidans)	3 / 3	LEU A 55 MET A 12 ASP A 15	None	0.88A	3v5wA-2zayA: undetectable	3v5wA-2zayA: 11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0R_A_PX9A201_0 (BETA-LACTOGLOBULIN)	2zay	RESPONSE REGULATOR RECEIVER PROTEIN (Desulfuromonas acetoxidans)	5 / 12	LEU A 13 ILE A 57 ILE A 86 ILE A 109 VAL A 113	None	0.84A	4y0rA-2zayA: undetectable	4y0rA-2zayA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0R_A_PX9A201_0 (BETA-LACTOGLOBULIN)	2zay	RESPONSE REGULATOR RECEIVER PROTEIN (Desulfuromonas acetoxidans)	5 / 12	LEU A 13 ILE A 57 LEU A 55 ILE A 86 ILE A 109	None	1.06A	4y0rA-2zayA: undetectable	4y0rA-2zayA: 23.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2RHM_D_BEZD194_0","PUTATIVE KINASE","2zay","RESPONSE REGULATOR RECEIVER PROTEIN","Desulfuromonas acetoxidans",4,"ILE A 109;ARG A 117;ARG A 121;ASP A 107","None","1.27A","2rhmD-2zayA:3.4","2rhmD-2zayA:19.79"],["2WX2_B_TPFB1460_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","2zay","RESPONSE REGULATOR RECEIVER PROTEIN","Desulfuromonas acetoxidans",4,"MET A 103;PHE A 105;ALA A  87;ALA A  60","None","0.96A","2wx2B-2zayA:undetectable","2wx2B-2zayA:14.80"],["3V5W_A_8PRA701_2","G-PROTEIN COUPLED RECEPTOR KINASE 2","2zay","RESPONSE REGULATOR RECEIVER PROTEIN","Desulfuromonas acetoxidans",3,"LEU A  55;MET A  12;ASP A  15","None","0.88A","3v5wA-2zayA:undetectable","3v5wA-2zayA:11.18"],["4Y0R_A_PX9A201_0","BETA-LACTOGLOBULIN","2zay","RESPONSE REGULATOR RECEIVER PROTEIN","Desulfuromonas acetoxidans",5,"LEU A  13;ILE A  57;ILE A  86;ILE A 109;VAL A 113","None","0.84A","4y0rA-2zayA:undetectable","4y0rA-2zayA:23.08"],["4Y0R_A_PX9A201_0","BETA-LACTOGLOBULIN","2zay","RESPONSE REGULATOR RECEIVER PROTEIN","Desulfuromonas acetoxidans",5,"LEU A  13;ILE A  57;LEU A  55;ILE A  86;ILE A 109","None","1.06A","4y0rA-2zayA:undetectable","4y0rA-2zayA:23.08"]]