SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 7 LEU A  34
LEU A  30
LEU A 109
GLN A  38
 None
 1.11A 1kt3A-2zb3A:
undetectable		 1kt3A-2zb3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 SER A 257
ASN A 207
VAL A 213
ALA A 214
VAL A 159
 None
 1.30A 2nniA-2zb3A:
undetectable		 2nniA-2zb3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 LEU A 196
GLY A 201
ALA A 204
ALA A 205
VAL A 206
 None
 0.87A 2oc8A-2zb3A:
undetectable		 2oc8A-2zb3A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		7 / 10 TYR A  51
TYR A  64
PHE A  99
TYR A 259
TYR A 265
VAL A 289
LEU A 290
 None
None
None
NDP  A 900 (-4.5A)
None
NDP  A 900 (-3.7A)
None
 0.59A 2w98A-2zb3A:
34.0		 2w98A-2zb3A:
85.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 7 TYR A  64
TYR A 100
LEU A 290
ASN A 291
 None
 0.64A 2w98A-2zb3A:
34.0
2w98B-2zb3A:
34.4		 2w98A-2zb3A:
85.07
2w98B-2zb3A:
85.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		7 / 9 THR A  97
PHE A  99
GLU A 115
VAL A 117
PHE A 296
GLU A 297
ILE A 300
 None
 0.97A 2w98A-2zb3A:
34.0		 2w98A-2zb3A:
85.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		7 / 9 THR A  97
PHE A  99
VAL A 117
GLY A 134
PHE A 296
GLU A 297
ILE A 300
 None
 0.77A 2w98A-2zb3A:
34.0		 2w98A-2zb3A:
85.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		6 / 8 TYR A  51
PHE A  99
TYR A 259
TYR A 265
VAL A 289
LEU A 290
 None
None
NDP  A 900 (-4.5A)
None
NDP  A 900 (-3.7A)
None
 0.37A 2w98B-2zb3A:
34.4		 2w98B-2zb3A:
85.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 6 THR A  97
GLU A 115
LYS A 293
ILE A 300
 None
 1.38A 2w98B-2zb3A:
34.4		 2w98B-2zb3A:
85.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 6 THR A  97
GLU A 115
PHE A 296
ILE A 300
 None
 0.88A 2w98B-2zb3A:
34.4		 2w98B-2zb3A:
85.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 6 LEU A 217
ARG A 280
MET A 244
VAL A 263
 None
 1.04A 2ygoA-2zb3A:
undetectable		 2ygoA-2zb3A:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 9 TYR A  51
THR A  60
TYR A 259
VAL A 289
LEU A 290
 None
None
NDP  A 900 (-4.5A)
NDP  A 900 (-3.7A)
None
 0.94A 2zb8A-2zb3A:
55.2		 2zb8A-2zb3A:
84.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 9 TYR A  51
TYR A 100
TYR A 259
VAL A 289
LEU A 290
 None
None
NDP  A 900 (-4.5A)
NDP  A 900 (-3.7A)
None
 0.45A 2zb8A-2zb3A:
55.2		 2zb8A-2zb3A:
84.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 11 ILE A 342
LEU A 126
LEU A 130
ILE A  79
THR A  43
 None
 1.35A 3a50B-2zb3A:
undetectable		 3a50B-2zb3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 10 PHE A 202
ILE A 186
ALA A 220
VAL A 160
LEU A 196
 None
 1.06A 3ay0A-2zb3A:
8.5		 3ay0A-2zb3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 5 VAL A 183
VAL A 184
GLN A 243
PHE A 229
 None
 1.27A 3bjwB-2zb3A:
undetectable		 3bjwB-2zb3A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 SER A 161
GLY A 233
GLY A 254
 None
None
NDP  A 900 (-3.4A)
 0.44A 3bogA-2zb3A:
undetectable
3bogC-2zb3A:
undetectable		 3bogA-2zb3A:
undetectable
3bogC-2zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 4 SER A 161
GLY A 162
GLY A 233
GLY A 254
 None
NDP  A 900 ( 4.8A)
None
NDP  A 900 (-3.4A)
 0.72A 3bogB-2zb3A:
undetectable
3bogD-2zb3A:
undetectable		 3bogB-2zb3A:
undetectable
3bogD-2zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		3 / 3 GLU A 316
SER A  47
VAL A  48
 None
 0.76A 3eeoA-2zb3A:
undetectable		 3eeoA-2zb3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 7 VAL A 183
ILE A 251
THR A 139
GLY A 172
 None
None
NDP  A 900 (-3.1A)
None
 0.96A 3gssA-2zb3A:
undetectable		 3gssA-2zb3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		4 / 7 VAL A 183
ILE A 251
THR A 139
GLY A 172
 None
None
NDP  A 900 (-3.1A)
None
 0.91A 3gssB-2zb3A:
undetectable		 3gssB-2zb3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 SER A 140
ASP A 230
CYH A 167
ASP A  49
TYR A 265
 None
None
NDP  A 900 (-3.5A)
None
None
 1.48A 3havC-2zb3A:
0.1		 3havC-2zb3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 VAL A 314
GLY A 165
ALA A 166
SER A 169
LEU A 170
 None
NDP  A 900 (-3.1A)
NDP  A 900 (-3.4A)
None
None
 1.06A 3n8zB-2zb3A:
undetectable		 3n8zB-2zb3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 11 GLN A 145
LEU A 303
PHE A 229
VAL A 160
ILE A 251
 None
 1.45A 4claA-2zb3A:
undetectable		 4claA-2zb3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 10 VAL A 314
GLY A 165
ALA A 166
SER A 169
LEU A 170
 None
NDP  A 900 (-3.1A)
NDP  A 900 (-3.4A)
None
None
 1.12A 4ph9B-2zb3A:
undetectable		 4ph9B-2zb3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 ALA A 164
GLY A 185
GLY A 201
PHE A 202
GLU A 199
 None
 1.20A 4r29C-2zb3A:
undetectable		 4r29C-2zb3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2zb3 PROSTAGLANDIN
REDUCTASE 2
(Mus
musculus) 		5 / 12 GLY A 137
GLY A 131
ALA A 166
ALA A 171
ILE A 174
 None
None
NDP  A 900 (-3.4A)
None
None
 1.11A 5bw4B-2zb3A:
4.8		 5bw4B-2zb3A:
19.35