SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 12 ALA A 163
GLY A 165
GLY A 339
ILE A 206
ASP A 211
 None
NAP  A 500 (-3.2A)
None
None
None
 0.95A 1sqfA-2zb4A:
7.5		 1sqfA-2zb4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		3 / 3 PHE A  23
VAL A  74
TRP A 103
 None
 0.88A 2cc8A-2zb4A:
undetectable		 2cc8A-2zb4A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		3 / 3 PHE A  23
VAL A  74
TRP A 103
 None
 0.89A 2ccbA-2zb4A:
undetectable		 2ccbA-2zb4A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 12 LEU A 252
ILE A 251
PHE A 229
SER A 161
LEU A 290
 None
None
None
None
5OP  A 600 (-3.7A)
 1.26A 2lbdA-2zb4A:
undetectable		 2lbdA-2zb4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 12 SER A 257
ASN A 207
VAL A 213
ALA A 214
VAL A 159
 NAP  A 500 (-4.9A)
None
None
None
None
 1.16A 2nniA-2zb4A:
undetectable		 2nniA-2zb4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		3 / 3 PHE A  23
VAL A  74
TRP A 103
 None
 0.88A 2vx9A-2zb4A:
undetectable		 2vx9A-2zb4A:
12.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		7 / 10 TYR A  51
ILE A  65
TYR A 259
TYR A 265
LEU A 288
VAL A 289
LEU A 290
 5OP  A 600 (-3.4A)
5OP  A 600 ( 4.6A)
NAP  A 500 (-4.4A)
None
NAP  A 500 (-4.7A)
NAP  A 500 ( 3.6A)
5OP  A 600 (-3.7A)
 0.87A 2w98A-2zb4A:
57.6		 2w98A-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 9 THR A  97
GLU A 115
VAL A 117
GLY A 134
ILE A 300
 None
 0.61A 2w98A-2zb4A:
57.6		 2w98A-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 9 THR A  97
VAL A 117
GLY A 134
PHE A 296
ILE A 300
 None
 0.73A 2w98A-2zb4A:
57.6		 2w98A-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 8 TYR A  51
ILE A  65
TYR A 259
TYR A 265
LEU A 288
 5OP  A 600 (-3.4A)
5OP  A 600 ( 4.6A)
NAP  A 500 (-4.4A)
None
NAP  A 500 (-4.7A)
 0.61A 2w98B-2zb4A:
57.9		 2w98B-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		6 / 8 TYR A  51
TYR A 259
TYR A 265
LEU A 288
VAL A 289
LEU A 290
 5OP  A 600 (-3.4A)
NAP  A 500 (-4.4A)
None
NAP  A 500 (-4.7A)
NAP  A 500 ( 3.6A)
5OP  A 600 (-3.7A)
 0.52A 2w98B-2zb4A:
57.9		 2w98B-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 6 LEU A 288
ASN A 291
LYS A 293
ASP A 294
 NAP  A 500 (-4.7A)
None
None
None
 0.57A 2w98A-2zb4A:
57.6
2w98B-2zb4A:
57.9		 2w98A-2zb4A:
97.49
2w98B-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 6 THR A  97
GLU A 115
LYS A 293
PHE A 296
ILE A 300
 None
 0.64A 2w98B-2zb4A:
57.9		 2w98B-2zb4A:
97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 5 TYR A  51
ILE A  65
MET A 135
LEU A 288
LEU A 290
 5OP  A 600 (-3.4A)
5OP  A 600 ( 4.6A)
5OP  A 600 ( 2.7A)
NAP  A 500 (-4.7A)
5OP  A 600 (-3.7A)
 0.45A 2zb7A-2zb4A:
60.2		 2zb7A-2zb4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		8 / 9 TYR A  51
CYH A  54
PHE A  99
TYR A 100
TYR A 259
LEU A 288
VAL A 289
LEU A 290
 5OP  A 600 (-3.4A)
None
5OP  A 600 (-4.5A)
5OP  A 600 (-4.9A)
NAP  A 500 (-4.4A)
NAP  A 500 (-4.7A)
NAP  A 500 ( 3.6A)
5OP  A 600 (-3.7A)
 0.59A 2zb8A-2zb4A:
56.8		 2zb8A-2zb4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		6 / 9 TYR A  51
CYH A  54
THR A  60
TYR A 259
LEU A 288
VAL A 289
 5OP  A 600 (-3.4A)
None
None
NAP  A 500 (-4.4A)
NAP  A 500 (-4.7A)
NAP  A 500 ( 3.6A)
 1.01A 2zb8A-2zb4A:
56.8		 2zb8A-2zb4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 6 VAL A   6
VAL A   7
PHE A 329
ARG A   5
 None
 1.19A 3bjwF-2zb4A:
undetectable		 3bjwF-2zb4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 5 VAL A 183
VAL A 184
GLN A 243
PHE A 229
 None
 1.33A 3bjwB-2zb4A:
undetectable		 3bjwB-2zb4A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		3 / 3 SER A 161
GLY A 233
GLY A 254
 None
None
NAP  A 500 (-3.1A)
 0.49A 3bogA-2zb4A:
undetectable
3bogC-2zb4A:
undetectable		 3bogA-2zb4A:
undetectable
3bogC-2zb4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 4 SER A 161
GLY A 162
GLY A 233
GLY A 254
 None
NAP  A 500 ( 4.7A)
None
NAP  A 500 (-3.1A)
 0.73A 3bogB-2zb4A:
undetectable
3bogD-2zb4A:
undetectable		 3bogB-2zb4A:
undetectable
3bogD-2zb4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 7 VAL A 183
ILE A 251
THR A 139
GLY A 172
 None
None
NAP  A 500 (-3.0A)
None
 1.01A 3gssA-2zb4A:
undetectable		 3gssA-2zb4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 7 VAL A 183
ILE A 251
THR A 139
GLY A 172
 None
None
NAP  A 500 (-3.0A)
None
 0.95A 3gssB-2zb4A:
undetectable		 3gssB-2zb4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 12 SER A 140
ASP A 230
CYH A 167
ASP A  49
TYR A 265
 None
None
NAP  A 500 (-3.6A)
None
None
 1.44A 3havC-2zb4A:
0.0		 3havC-2zb4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		5 / 11 GLN A 145
LEU A 303
PHE A 229
VAL A 160
ILE A 251
 None
 1.47A 4claA-2zb4A:
undetectable		 4claA-2zb4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		3 / 3 ASN A 212
ALA A 214
ARG A 218
 None
 0.51A 5cvtB-2zb4A:
2.0		 5cvtB-2zb4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 4 LEU A 109
ILE A 108
GLY A 111
ILE A  34
 None
 0.88A 5dzk3-2zb4A:
undetectable
5dzkm-2zb4A:
undetectable		 5dzk3-2zb4A:
0.56
5dzkm-2zb4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 8 GLU A 348
GLY A  93
THR A  97
TYR A  45
 None
SO4  A2003 ( 4.0A)
None
None
 0.86A 5flcB-2zb4A:
undetectable		 5flcB-2zb4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 8 GLU A 348
GLY A  93
THR A  97
TYR A  45
 None
SO4  A2003 ( 4.0A)
None
None
 0.86A 5flcF-2zb4A:
undetectable		 5flcF-2zb4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 6 VAL A 240
VAL A 225
TYR A 228
ILE A 206
 None
 0.86A 5pbeA-2zb4A:
undetectable		 5pbeA-2zb4A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens) 		4 / 6 GLY A 234
ASN A 235
ASP A 238
SER A 270
 None
SO4  A2005 (-3.9A)
None
None
 0.87A 6dwdA-2zb4A:
undetectable
6dwdC-2zb4A:
undetectable		 6dwdA-2zb4A:
18.78
6dwdC-2zb4A:
18.78