SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 12 PHE A  62
ALA A 175
LEU A  55
GLY A 315
LEU A 146
 None
 1.23A 1qabF-2zbaA:
undetectable		 1qabF-2zbaA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 7 PHE A 398
TYR A  36
LEU A  34
TYR A 396
 None
 1.26A 1rmtB-2zbaA:
undetectable		 1rmtB-2zbaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 8 PHE A 400
LEU A 150
LEU A  55
LEU A 180
 None
 1.00A 2bfpC-2zbaA:
undetectable		 2bfpC-2zbaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 12 LEU A 252
LEU A 335
THR A 257
THR A 269
ALA A 272
 None
None
None
COA  A 462 (-3.7A)
None
 0.78A 2egvA-2zbaA:
undetectable		 2egvA-2zbaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 12 LEU A 252
LEU A 335
THR A 257
THR A 269
ALA A 272
 None
None
None
COA  A 462 (-3.7A)
None
 0.77A 2egvB-2zbaA:
undetectable		 2egvB-2zbaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 8 ARG A 201
SER A 386
GLY A 172
MET A 170
 None
COA  A 462 ( 2.6A)
None
None
 1.13A 2qd3A-2zbaA:
undetectable		 2qd3A-2zbaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 7 ILE A  18
GLN A 220
LEU A 217
LEU A 365
GLY A 364
 None
 1.31A 2qqcD-2zbaA:
0.0
2qqcE-2zbaA:
undetectable		 2qqcD-2zbaA:
15.92
2qqcE-2zbaA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 8 ILE A  18
GLN A 220
LEU A 217
LEU A 365
GLY A 364
 None
 1.28A 2qqcH-2zbaA:
0.0
2qqcK-2zbaA:
undetectable		 2qqcH-2zbaA:
15.92
2qqcK-2zbaA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 5 SER A  59
PRO A  86
GLY A  67
TRP A  64
 None
 1.29A 2y7kB-2zbaA:
undetectable		 2y7kB-2zbaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 6 SER A  59
PRO A  86
GLY A  67
TRP A  64
 None
 1.11A 2y7pA-2zbaA:
undetectable		 2y7pA-2zbaA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		3 / 3 PRO A 334
LEU A 335
GLN A 279
 None
 0.64A 3hznG-2zbaA:
undetectable
3hznH-2zbaA:
0.6		 3hznG-2zbaA:
20.39
3hznH-2zbaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 7 ARG A  57
SER A  49
ILE A  47
PHE A 400
 None
 1.04A 3ln1C-2zbaA:
undetectable		 3ln1C-2zbaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 12 LEU A  25
ALA A 359
VAL A 371
LEU A 373
GLY A 364
 ZBA  A 463 (-4.3A)
None
None
ZBA  A 463 ( 4.6A)
None
 1.07A 3uq6B-2zbaA:
undetectable		 3uq6B-2zbaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		3 / 3 LEU A 385
MET A 320
ASP A 169
 None
ZBA  A 463 (-3.8A)
None
 0.84A 3v5wA-2zbaA:
undetectable		 3v5wA-2zbaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 12 LEU A  25
ALA A 359
VAL A 371
LEU A 373
GLY A 364
 ZBA  A 463 (-4.3A)
None
None
ZBA  A 463 ( 4.6A)
None
 1.08A 3vaqB-2zbaA:
undetectable		 3vaqB-2zbaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		5 / 12 ALA A 455
LEU A 252
ALA A 248
ILE A 383
LEU A 445
 None
 1.04A 4nqaH-2zbaA:
undetectable		 4nqaH-2zbaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		3 / 3 ARG A 444
ASP A 448
ARG A 283
 None
 0.57A 4wq4B-2zbaA:
undetectable		 4wq4B-2zbaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		4 / 7 LEU A 273
THR A 281
MET A 442
MET A 420
 None
 1.46A 5ljcA-2zbaA:
undetectable		 5ljcA-2zbaA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		3 / 3 LEU A 317
ASP A 174
ILE A 176
 None
 0.62A 6dh0B-2zbaA:
undetectable		 6dh0B-2zbaA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E
(Fusarium
sporotrichioides) 		3 / 3 TRP A  64
ILE A 176
GLU A 193
 None
 0.87A 6hcxA-2zbaA:
undetectable		 6hcxA-2zbaA:
11.34