SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		5 / 12 ALA A 240
PHE A 244
SER A 171
ILE A 169
LEU A 167
 None
 1.24A 1dreA-2zbkA:
undetectable		 1dreA-2zbkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 8 ALA B 335
GLY B 360
ALA B 357
ILE B 362
 None
 0.74A 1gtnI-2zbkB:
undetectable
1gtnJ-2zbkB:
undetectable		 1gtnI-2zbkB:
11.13
1gtnJ-2zbkB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		4 / 4 GLY A 296
ASP A 386
GLY A 304
THR A 352
 None
 1.06A 1hxbB-2zbkA:
undetectable		 1hxbB-2zbkA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ASN B  42
SER B  43
ASP B  45
ASP B  76
THR B 170
 RDC  B 531 ( 4.1A)
RDC  B 531 (-3.2A)
None
RDC  B 531 (-2.9A)
RDC  B 531 (-2.5A)
 0.69A 1s14A-2zbkB:
15.0		 1s14A-2zbkB:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		5 / 12 PRO A 379
ILE A 258
THR A 260
SER A 298
PHE A 270
 None
 1.04A 1sg9A-2zbkA:
undetectable		 1sg9A-2zbkA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 MET B 412
ALA B 354
VAL B 316
GLY B 355
ILE B 322
 None
 1.28A 2dcfA-2zbkB:
undetectable		 2dcfA-2zbkB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 10 TYR B 373
ILE B 377
ARG B  37
ILE B 430
ILE B 420
 None
 1.16A 2dm6A-2zbkB:
undetectable
2dm6B-2zbkB:
undetectable		 2dm6A-2zbkB:
20.30
2dm6B-2zbkB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		3 / 3 VAL B 387
TRP B 389
VAL B 392
 None
 0.91A 2izqA-2zbkB:
undetectable
2izqB-2zbkB:
undetectable		 2izqA-2zbkB:
2.39
2izqB-2zbkB:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 TYR B  33
ARG B  30
GLY B 106
ASN B 375
LEU B 415
 None
 0.99A 2nyrB-2zbkB:
undetectable		 2nyrB-2zbkB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		4 / 6 LEU A 178
LEU A 167
ILE A 176
ARG A 168
 None
 0.85A 2rlfC-2zbkA:
undetectable
2rlfD-2zbkA:
undetectable		 2rlfC-2zbkA:
8.36
2rlfD-2zbkA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		5 / 12 ALA A 187
ARG A 242
PHE A 244
ILE A 229
LEU A 248
 None
 1.11A 2w3bA-2zbkA:
undetectable		 2w3bA-2zbkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		5 / 10 ILE A 195
LEU A 252
ILE A 169
ILE A 229
PHE A 244
 None
 1.20A 2w9sC-2zbkA:
undetectable		 2w9sC-2zbkA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 6 ILE B  56
SER B  43
LEU B  44
THR B  47
 None
RDC  B 531 (-3.2A)
None
None
 0.79A 3deuB-2zbkB:
undetectable		 3deuB-2zbkB:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		5 / 12 ALA A 240
PHE A 244
SER A 171
ILE A 169
LEU A 167
 None
 1.21A 3ia4C-2zbkA:
undetectable		 3ia4C-2zbkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 ASN B  42
SER B  43
ASP B  45
ASP B  76
THR B 170
 RDC  B 531 ( 4.1A)
RDC  B 531 (-3.2A)
None
RDC  B 531 (-2.9A)
RDC  B 531 (-2.5A)
 0.67A 3lpsA-2zbkB:
19.9		 3lpsA-2zbkB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		4 / 7 PHE A 273
ASP A 238
ILE A 231
VAL A 205
 None
 0.96A 3p6hA-2zbkA:
undetectable		 3p6hA-2zbkA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		4 / 7 ILE A 229
ILE A 231
VAL A 245
LEU A 248
 None
 0.50A 3r9vA-2zbkA:
undetectable
3r9vB-2zbkA:
undetectable		 3r9vA-2zbkA:
20.96
3r9vB-2zbkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		3 / 3 ARG A 242
ASP A 136
GLN A 132
 None
 0.91A 4azsA-2zbkA:
undetectable		 4azsA-2zbkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		3 / 3 ARG B  18
LYS B  14
LYS B  17
 None
 1.39A 4k50E-2zbkB:
undetectable		 4k50E-2zbkB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 5 TYR B 190
LEU B  32
GLU B  38
VAL B 116
 None
 1.30A 4nkvA-2zbkB:
undetectable		 4nkvA-2zbkB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 6 MET B 107
ILE B  56
ILE B  58
VAL B  74
 None
 0.88A 4olmA-2zbkB:
undetectable		 4olmA-2zbkB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		4 / 8 LEU A 248
VAL A 163
VAL A 207
LEU A 167
 None
 1.09A 4pwdC-2zbkA:
undetectable		 4pwdC-2zbkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ASN B  42
SER B  43
ASP B  45
ASP B  76
THR B 170
 RDC  B 531 ( 4.1A)
RDC  B 531 (-3.2A)
None
RDC  B 531 (-2.9A)
RDC  B 531 (-2.5A)
 0.67A 4urnA-2zbkB:
16.1		 4urnA-2zbkB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ASN B  42
SER B  43
ASP B  45
ASP B  76
THR B 170
 RDC  B 531 ( 4.1A)
RDC  B 531 (-3.2A)
None
RDC  B 531 (-2.9A)
RDC  B 531 (-2.5A)
 0.70A 4urnB-2zbkB:
16.0		 4urnB-2zbkB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 11 ASN B  42
SER B  43
ASP B  45
ASP B  76
THR B 170
 RDC  B 531 ( 4.1A)
RDC  B 531 (-3.2A)
None
RDC  B 531 (-2.9A)
RDC  B 531 (-2.5A)
 0.65A 4urnC-2zbkB:
16.3		 4urnC-2zbkB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		5 / 12 SER B  43
ASP B  76
ILE B  81
PRO B  82
THR B 170
 RDC  B 531 (-3.2A)
RDC  B 531 (-2.9A)
RDC  B 531 (-4.3A)
None
RDC  B 531 (-2.5A)
 0.87A 4uroD-2zbkB:
16.4		 4uroD-2zbkB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 7 ARG B 372
ASP B 386
ILE B 430
TYR B 422
 None
 1.33A 5a06B-2zbkB:
undetectable		 5a06B-2zbkB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		6 / 12 ALA A 185
THR A 241
ARG A 247
LEU A 248
ILE A 231
THR A 181
 None
 1.49A 5eajA-2zbkA:
undetectable		 5eajA-2zbkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		3 / 3 ASP B 386
ARG B 186
ARG B 193
 None
 0.73A 5eajB-2zbkB:
undetectable		 5eajB-2zbkB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 6 GLU B 439
PHE B 350
GLU B 434
VAL B 433
 None
 1.24A 5h4dA-2zbkB:
undetectable		 5h4dA-2zbkB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 6 VAL B 236
TYR B  99
GLN B 263
HIS B 348
 None
 1.16A 5kkzA-2zbkB:
undetectable
5kkzG-2zbkB:
undetectable		 5kkzA-2zbkB:
21.89
5kkzG-2zbkB:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 7 HIS B 348
VAL B 236
TYR B  99
GLN B 263
 None
 1.16A 5kkzC-2zbkB:
undetectable
5kkzE-2zbkB:
undetectable		 5kkzC-2zbkB:
16.50
5kkzE-2zbkB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 7 HIS B 348
VAL B 236
TYR B  99
GLN B 263
 None
 1.13A 5kkzM-2zbkB:
undetectable
5kkzO-2zbkB:
undetectable		 5kkzM-2zbkB:
16.50
5kkzO-2zbkB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B
(Sulfolobus
shibatae) 		4 / 8 GLY B  78
ILE B  79
ASP B  48
PRO B 225
 None
 1.01A 6ag0C-2zbkB:
undetectable		 6ag0C-2zbkB:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2zbk TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A
(Sulfolobus
shibatae) 		5 / 12 ILE A 378
VAL A 207
LEU A 373
PHE A 222
SER A 228
 None
 1.11A 6b52A-2zbkA:
undetectable		 6b52A-2zbkA:
21.57