SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		3 / 3 GLU A  92
LYS A  84
VAL A  85
 None
MPD  A 903 (-2.9A)
None
 0.93A 1l2iA-2zbtA:
undetectable		 1l2iA-2zbtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		4 / 7 ILE A  69
ILE A  95
LEU A  96
ILE A  99
 None
 0.89A 2q83A-2zbtA:
undetectable		 2q83A-2zbtA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		3 / 3 LEU A 208
PRO A 209
ARG A 141
 None
 0.59A 2qd4B-2zbtA:
2.0		 2qd4B-2zbtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		4 / 7 GLU A  49
ARG A  63
GLU A  92
PRO A  67
 None
 1.20A 3ql6A-2zbtA:
undetectable		 3ql6A-2zbtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		5 / 12 VAL A  45
ASP A 102
ILE A 104
VAL A 101
ILE A  99
 None
 1.25A 4eb6B-2zbtA:
undetectable
4eb6C-2zbtA:
undetectable		 4eb6B-2zbtA:
21.12
4eb6C-2zbtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		4 / 8 THR A 151
GLY A 216
GLY A 217
VAL A 160
 None
MPD  A 903 (-3.6A)
None
None
 0.83A 4qvvK-2zbtA:
undetectable
4qvvL-2zbtA:
undetectable		 4qvvK-2zbtA:
23.86
4qvvL-2zbtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		4 / 8 THR A 151
GLY A 216
GLY A 217
VAL A 160
 None
MPD  A 903 (-3.6A)
None
None
 0.82A 4qvvY-2zbtA:
undetectable
4qvvZ-2zbtA:
undetectable		 4qvvY-2zbtA:
23.86
4qvvZ-2zbtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		4 / 6 ARG A 256
ASP A 273
LEU A 274
ASP A 246
 None
 1.17A 5tdzA-2zbtA:
undetectable		 5tdzA-2zbtA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		4 / 8 ALA A 259
VAL A 258
PHE A 213
GLY A  22
 None
 0.98A 5v0vA-2zbtA:
undetectable		 5v0vA-2zbtA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2zbt PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Thermus
thermophilus) 		5 / 11 GLU A  39
ALA A  42
ALA A 251
ILE A 241
VAL A 237
 None
None
None
None
MPD  A 903 (-4.9A)
 1.05A 5yk2A-2zbtA:
undetectable		 5yk2A-2zbtA:
24.36