SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 7 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
 None
 0.88A 1rqpB-2zbvA:
30.5		 1rqpB-2zbvA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		6 / 8 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
 None
 0.88A 1rqpC-2zbvA:
30.6		 1rqpC-2zbvA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		6 / 8 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
 None
 0.86A 1rqpA-2zbvA:
30.6		 1rqpA-2zbvA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		6 / 8 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
 None
 0.87A 2v7uA-2zbvA:
30.5		 2v7uA-2zbvA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 7 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
 None
 0.90A 2v7uB-2zbvA:
30.5		 2v7uB-2zbvA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1300_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		7 / 9 ASP A 178
PHE A 180
ASN A 182
PHE A 220
SER A 234
ALA A 241
ASN A 243
 None
 0.86A 2v7uC-2zbvA:
30.6		 2v7uC-2zbvA:
29.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZBU_A_ADNA501_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 4 PHE A 180
ASN A 182
PHE A 220
ASN A 243
 None
 0.15A 2zbuA-2zbvA:
42.9		 2zbuA-2zbvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZBU_B_ADNB502_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 5 ASP A   7
TRP A   8
PHE A  41
TYR A  69
VAL A  71
 ADN  A 501 (-3.0A)
ADN  A 501 (-4.6A)
ADN  A 501 (-4.3A)
None
ADN  A 501 ( 4.5A)
 0.19A 2zbuB-2zbvA:
41.8		 2zbuB-2zbvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZBU_C_ADNC503_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 4 PHE A 180
ASN A 182
PHE A 220
ASN A 243
 None
 0.10A 2zbuC-2zbvA:
42.9		 2zbuC-2zbvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		3 / 3 PHE A 180
ASN A 182
PHE A 220
 None
 0.08A 2zbuD-2zbvA:
41.5		 2zbuD-2zbvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A   2
ILE A  22
VAL A  21
VAL A  66
LEU A 139
 None
None
None
ADN  A 501 (-4.9A)
None
 1.22A 3elzC-2zbvA:
undetectable		 3elzC-2zbvA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A   5
THR A   6
GLY A 128
ALA A 133
 None
 0.81A 3jusA-2zbvA:
undetectable		 3jusA-2zbvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A   5
THR A   6
GLY A 128
ALA A 133
 None
 0.81A 3jusA-2zbvA:
undetectable		 3jusA-2zbvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A   5
THR A   6
GLY A 128
ALA A 133
 None
 0.80A 3jusB-2zbvA:
undetectable		 3jusB-2zbvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 8 THR A   6
GLY A 128
ALA A 133
ILE A  31
 None
 0.67A 3jusB-2zbvA:
undetectable		 3jusB-2zbvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A  18
ARG A 129
LYS A 119
 None
 0.98A 3kp3B-2zbvA:
undetectable		 3kp3B-2zbvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 12 GLU A 173
ILE A 259
ALA A 175
THR A 185
ILE A 240
 None
 1.16A 3ndiA-2zbvA:
undetectable		 3ndiA-2zbvA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 5 HIS A  48
SER A  47
THR A  97
ASP A  56
 None
 1.15A 3tm4A-2zbvA:
undetectable		 3tm4A-2zbvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 5 HIS A  48
SER A  47
THR A  97
ASP A  56
 None
 1.14A 3tm4B-2zbvA:
undetectable		 3tm4B-2zbvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 9 ALA A  18
ILE A  31
ALA A 136
ALA A 137
ILE A   2
 None
 1.09A 4lbgB-2zbvA:
2.7		 4lbgB-2zbvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 6 VAL A  71
ARG A 129
VAL A  66
TRP A   8
 ADN  A 501 ( 4.5A)
None
ADN  A 501 (-4.9A)
ADN  A 501 (-4.6A)
 1.44A 5adeA-2zbvA:
undetectable
5adeB-2zbvA:
undetectable		 5adeA-2zbvA:
21.51
5adeB-2zbvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 5 SER A  47
ALA A  46
HIS A  48
LEU A 158
 None
 1.43A 5dzkb-2zbvA:
undetectable
5dzkp-2zbvA:
undetectable		 5dzkb-2zbvA:
22.06
5dzkp-2zbvA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 5 SER A  47
ALA A  46
HIS A  48
LEU A 158
 None
 1.41A 5dzkc-2zbvA:
undetectable
5dzkq-2zbvA:
undetectable		 5dzkc-2zbvA:
22.06
5dzkq-2zbvA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 11 ILE A 176
ASN A  42
VAL A  67
ASP A   7
PRO A  40
 None
None
ADN  A 501 (-4.3A)
ADN  A 501 (-3.0A)
None
 1.48A 5z0kA-2zbvA:
undetectable
5z0kB-2zbvA:
undetectable		 5z0kA-2zbvA:
15.71
5z0kB-2zbvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 11 ILE A 176
ASN A  42
VAL A  67
ASP A   7
PRO A  40
 None
None
ADN  A 501 (-4.3A)
ADN  A 501 (-3.0A)
None
 1.49A 5z0lA-2zbvA:
undetectable
5z0lB-2zbvA:
undetectable		 5z0lA-2zbvA:
15.71
5z0lB-2zbvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		4 / 6 GLU A 173
ARG A  44
GLU A 255
ALA A 175
 None
 1.05A 6an0A-2zbvA:
undetectable		 6an0A-2zbvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 195
THR A 185
ASN A 186
 None
 0.56A 6baaE-2zbvA:
undetectable		 6baaE-2zbvA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 195
THR A 185
ASN A 186
 None
 0.55A 6baaF-2zbvA:
undetectable		 6baaF-2zbvA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 195
THR A 185
ASN A 186
 None
 0.56A 6baaG-2zbvA:
undetectable		 6baaG-2zbvA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 195
THR A 185
ASN A 186
 None
 0.56A 6baaH-2zbvA:
undetectable		 6baaH-2zbvA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2zbv UNCHARACTERIZED
CONSERVED PROTEIN
(Thermotoga
maritima) 		5 / 12 THR A   6
VAL A  65
VAL A  89
ASN A  93
VAL A  71
 None
None
None
None
ADN  A 501 ( 4.5A)
 1.46A 6iblA-2zbvA:
undetectable		 6iblA-2zbvA:
21.52