SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 PRO A  36
GLY A  14
VAL A  68
ALA A 117
ALA A 116
 FAD  A1002 (-4.2A)
FAD  A1002 (-3.6A)
None
FAD  A1002 (-3.5A)
FAD  A1002 (-4.8A)
 1.06A 1nw5A-2zbwA:
undetectable		 1nw5A-2zbwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 6 ALA A 306
ILE A 307
HIS A 311
VAL A 322
 None
 1.19A 3nneG-2zbwA:
11.9		 3nneG-2zbwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		3 / 3 LEU A 197
HIS A 201
MET A 198
 None
 0.92A 3thrD-2zbwA:
2.9		 3thrD-2zbwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 10 THR A 210
PHE A 187
LEU A 156
VAL A 244
VAL A 228
 None
 1.43A 3u9fI-2zbwA:
undetectable		 3u9fI-2zbwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 10 THR A 210
PHE A 187
LEU A 156
VAL A 244
VAL A 228
 None
 1.43A 3u9fK-2zbwA:
undetectable		 3u9fK-2zbwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 11 THR A 210
PHE A 187
LEU A 156
VAL A 244
VAL A 228
 None
 1.38A 3u9fN-2zbwA:
undetectable
3u9fO-2zbwA:
undetectable		 3u9fN-2zbwA:
18.54
3u9fO-2zbwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 9 THR A 210
PHE A 187
LEU A 156
VAL A 244
VAL A 228
 None
 1.35A 3u9fP-2zbwA:
undetectable		 3u9fP-2zbwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 THR A 210
PHE A 187
LEU A 156
VAL A 244
VAL A 228
 None
 1.39A 3u9fP-2zbwA:
undetectable
3u9fS-2zbwA:
undetectable		 3u9fP-2zbwA:
18.54
3u9fS-2zbwA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  91
GLY A  12
PHE A  33
ILE A 114
ALA A 284
 None
FAD  A1002 (-3.0A)
None
None
None
 1.05A 3uwlB-2zbwA:
undetectable		 3uwlB-2zbwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 LEU A  91
GLY A  12
PHE A  33
ILE A 114
ALA A 284
 None
FAD  A1002 (-3.0A)
None
None
None
 1.05A 3uwlD-2zbwA:
undetectable		 3uwlD-2zbwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 7 ASP A   7
SER A  30
THR A   6
PHE A  31
 None
 1.03A 4ac9C-2zbwA:
undetectable		 4ac9C-2zbwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 6 PRO A 324
ARG A  27
GLY A  25
ALA A 306
 None
 1.10A 4g0uA-2zbwA:
undetectable		 4g0uA-2zbwA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 6 LEU A 257
ALA A 121
LEU A 254
THR A 252
 None
FAD  A1002 (-3.5A)
None
None
 0.98A 4ikiB-2zbwA:
undetectable		 4ikiB-2zbwA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  12
ASP A  35
PHE A  31
ILE A  10
ALA A  20
 FAD  A1002 (-3.0A)
FAD  A1002 (-2.6A)
None
None
None
 1.10A 4wh5A-2zbwA:
undetectable		 4wh5A-2zbwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 6 LEU A 257
ALA A 121
LEU A 254
THR A 252
 None
FAD  A1002 (-3.5A)
None
None
 1.04A 5l4iA-2zbwA:
undetectable		 5l4iA-2zbwA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 10 LEU A  44
GLY A  42
LEU A  67
VAL A  72
LEU A  71
 None
FAD  A1002 (-3.2A)
None
None
None
 1.08A 5o96G-2zbwA:
undetectable
5o96H-2zbwA:
undetectable		 5o96G-2zbwA:
25.28
5o96H-2zbwA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 7 PHE A  22
GLY A  21
GLY A  17
THR A   6
 None
 0.70A 5ybbB-2zbwA:
undetectable		 5ybbB-2zbwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		5 / 9 ALA A 308
VAL A  24
ALA A  20
VAL A   8
GLY A  17
 None
 1.28A 6bklA-2zbwA:
undetectable
6bklB-2zbwA:
undetectable
6bklC-2zbwA:
undetectable
6bklD-2zbwA:
undetectable		 6bklA-2zbwA:
8.70
6bklB-2zbwA:
8.70
6bklC-2zbwA:
8.70
6bklD-2zbwA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 5 LEU A 237
LEU A 156
THR A 210
ARG A 205
 None
 0.94A 6ew0F-2zbwA:
undetectable		 6ew0F-2zbwA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2zbw THIOREDOXIN
REDUCTASE
(Thermus
thermophilus) 		4 / 6 LEU A 237
LEU A 156
THR A 210
ARG A 205
 None
 0.94A 6ew0G-2zbwA:
undetectable		 6ew0G-2zbwA:
12.84