SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 7 VAL A 116
ILE A 119
HIS A 345
GLU A 282
 None
 1.06A 1j96B-2zbzA:
undetectable		 1j96B-2zbzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 LEU A 190
ASN A 194
LEU A 196
ALA A 197
SER A 236
 None
None
None
None
VDX  A 501 (-3.3A)
 1.17A 2aa5B-2zbzA:
undetectable		 2aa5B-2zbzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 LYS A 178
ASP A 145
ASN A 400
 None
 0.98A 2bm9A-2zbzA:
undetectable		 2bm9A-2zbzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 6 PRO A 166
HIS A 170
ASP A 175
TYR A 199
 None
 1.39A 2lh8A-2zbzA:
0.6		 2lh8A-2zbzA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 5 ALA A 361
ALA A 291
ALA A 294
GLN A 358
 HEM  A 413 (-3.5A)
HEM  A 413 ( 3.7A)
VDX  A 501 ( 3.8A)
None
 0.73A 2nyrB-2zbzA:
undetectable		 2nyrB-2zbzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 5 ILE A 235
LEU A 200
ASP A 195
PHE A 172
 None
 0.99A 2opxA-2zbzA:
undetectable		 2opxA-2zbzA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ILE A 258
THR A 259
LEU A 390
ASN A  19
VAL A 385
 None
 1.18A 2vn0A-2zbzA:
31.7		 2vn0A-2zbzA:
24.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ASN A 194
LEU A 240
ILE A 243
ALA A 244
THR A 248
 None
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
 0.97A 3a50A-2zbzA:
47.1		 3a50A-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ILE A  96
LEU A 240
ILE A 243
ALA A 244
THR A 248
 HEM  A 413 (-4.0A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
 0.54A 3a50A-2zbzA:
47.1		 3a50A-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 ILE A  96
LEU A 180
LEU A 240
ILE A 243
THR A 248
 HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
 0.72A 3a50B-2zbzA:
47.6		 3a50B-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 ILE A  96
LEU A 180
LEU A 240
ILE A 243
THR A 248
 HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
 0.66A 3a50C-2zbzA:
47.8		 3a50C-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		6 / 12 ILE A  96
LEU A 180
ASN A 194
ILE A 243
ALA A 244
THR A 248
 HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
None
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
 1.43A 3a50D-2zbzA:
47.7		 3a50D-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		6 / 12 ILE A  96
LEU A 180
ASN A 194
LEU A 240
ILE A 243
THR A 248
 HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
None
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
 1.37A 3a50E-2zbzA:
47.7		 3a50E-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ILE A  96
ASN A 194
LEU A 240
ILE A 243
THR A 248
 HEM  A 413 (-4.0A)
None
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
 1.12A 3a51D-2zbzA:
47.7		 3a51D-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ILE A  96
ASN A 194
ILE A 243
ALA A 244
THR A 248
 HEM  A 413 (-4.0A)
None
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
 1.07A 3a51E-2zbzA:
47.7		 3a51E-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		6 / 9 LEU A 180
ARG A 193
SER A 236
ILE A 243
ILE A 293
GLY A 295
 VDX  A 501 (-4.2A)
VDX  A 501 (-3.5A)
VDX  A 501 (-3.3A)
VDX  A 501 (-4.2A)
VDX  A 501 (-4.9A)
HEM  A 413 ( 4.4A)
 1.10A 3cv9A-2zbzA:
70.2		 3cv9A-2zbzA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		9 / 9 THR A  81
VAL A  88
SER A  91
LEU A 180
ARG A 193
SER A 236
ILE A 243
ILE A 293
GLY A 296
 VDX  A 501 (-4.4A)
VDX  A 501 ( 4.4A)
VDX  A 501 (-4.3A)
VDX  A 501 (-4.2A)
VDX  A 501 (-3.5A)
VDX  A 501 (-3.3A)
VDX  A 501 (-4.2A)
VDX  A 501 (-4.9A)
None
 0.39A 3cv9A-2zbzA:
70.2		 3cv9A-2zbzA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 ALA A 244
THR A 248
CYH A 355
 HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
HEM  A 413 (-2.3A)
 0.57A 3e4eA-2zbzA:
32.6		 3e4eA-2zbzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 ALA A 244
THR A 248
CYH A 355
 HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
HEM  A 413 (-2.3A)
 0.49A 3e4eB-2zbzA:
32.6		 3e4eB-2zbzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 9 LEU A 284
HIS A 345
GLU A 282
ILE A 290
LEU A 288
 None
None
None
HEM  A 413 ( 4.9A)
None
 1.29A 3hy7A-2zbzA:
undetectable		 3hy7A-2zbzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 9 LEU A 284
HIS A 345
GLU A 282
ILE A 290
LEU A 288
 None
None
None
HEM  A 413 ( 4.9A)
None
 1.31A 3hy7B-2zbzA:
undetectable		 3hy7B-2zbzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 ILE A 159
ARG A 193
ALA A 197
LEU A 196
ALA A 176
 None
VDX  A 501 (-3.5A)
None
None
None
 1.27A 3lw5B-2zbzA:
undetectable		 3lw5B-2zbzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 ILE A 159
PHE A 172
ALA A 197
LEU A 196
ALA A 176
 None
 1.36A 3lw5B-2zbzA:
undetectable		 3lw5B-2zbzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 6 ILE A 243
ALA A 244
THR A 248
ALA A 291
 VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
HEM  A 413 ( 3.7A)
 0.77A 3mdrB-2zbzA:
33.3		 3mdrB-2zbzA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ILE A 243
ALA A 244
GLU A 247
THR A 248
ALA A 291
 VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
None
HEM  A 413 (-3.2A)
HEM  A 413 ( 3.7A)
 0.96A 3mdvB-2zbzA:
33.5		 3mdvB-2zbzA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 LEU A 284
ASP A 292
ILE A 396
GLY A 398
VAL A 399
 None
 1.02A 3oxwC-2zbzA:
undetectable		 3oxwC-2zbzA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 LEU A 284
ASP A 292
ILE A 396
GLY A 398
VAL A 399
 None
 1.04A 3oxxA-2zbzA:
undetectable		 3oxxA-2zbzA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 LEU A 180
LEU A 240
ILE A 243
ALA A 244
THR A 248
 VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
 0.67A 3r9cA-2zbzA:
41.9		 3r9cA-2zbzA:
35.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ALA A 268
LEU A 270
LEU A 369
LEU A 261
LEU A 402
 None
 1.15A 3r9cA-2zbzA:
41.9		 3r9cA-2zbzA:
35.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 6 ALA A  51
ILE A 317
LEU A  45
ALA A  13
 None
 0.88A 3r9sA-2zbzA:
undetectable		 3r9sA-2zbzA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 8 PRO A  27
SER A 321
ILE A 322
ARG A  34
 None
 0.92A 3sfeB-2zbzA:
undetectable
3sfeC-2zbzA:
1.9		 3sfeB-2zbzA:
20.29
3sfeC-2zbzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 8 PRO A  27
SER A 321
ILE A 322
ARG A 325
 None
 1.05A 3sfeB-2zbzA:
undetectable
3sfeC-2zbzA:
1.9		 3sfeB-2zbzA:
20.29
3sfeC-2zbzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 8 PHE A  16
PRO A  14
GLY A  29
SER A  18
 None
 1.08A 3tzfB-2zbzA:
undetectable		 3tzfB-2zbzA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 5 LEU A 285
LEU A 284
LEU A 255
SER A 251
 None
 1.01A 3vhuA-2zbzA:
undetectable		 3vhuA-2zbzA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 ILE A  96
LEU A 180
LEU A 240
ILE A 243
ALA A 244
 HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
 0.63A 3vrmA-2zbzA:
47.7		 3vrmA-2zbzA:
37.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 LEU A 240
LEU A 241
LEU A 215
ILE A  96
SER A 112
 HEM  A 413 ( 4.5A)
HEM  A 413 (-4.5A)
None
HEM  A 413 (-4.0A)
None
 1.24A 4f4dB-2zbzA:
undetectable		 4f4dB-2zbzA:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.94A 4j6cA-2zbzA:
46.3		 4j6cA-2zbzA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.94A 4j6cB-2zbzA:
46.4		 4j6cB-2zbzA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.99A 4j6dA-2zbzA:
46.6		 4j6dA-2zbzA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 1.00A 4j6dB-2zbzA:
46.3		 4j6dB-2zbzA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 12 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.96A 4jbtA-2zbzA:
46.3		 4jbtA-2zbzA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 GLN A 397
ALA A 291
ALA A 289
ALA A 347
LEU A  64
 None
HEM  A 413 ( 3.7A)
None
HEM  A 413 (-4.5A)
None
 0.96A 4jbtB-2zbzA:
46.2		 4jbtB-2zbzA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 GLY A 217
ALA A 238
LEU A 163
GLY A 164
LEU A 285
 None
 1.13A 4kt0A-2zbzA:
undetectable
4kt0J-2zbzA:
undetectable		 4kt0A-2zbzA:
20.92
4kt0J-2zbzA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 THR A 237
LEU A  98
ILE A 229
MET A 109
LEU A 219
 None
 1.40A 4lhmA-2zbzA:
undetectable		 4lhmA-2zbzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 LEU A  69
LEU A  45
ALA A  80
ALA A  51
GLY A 296
 None
 1.44A 4rn6A-2zbzA:
undetectable		 4rn6A-2zbzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 ASP A 292
ARG A  73
ARG A 297
 None
VDX  A 501 ( 4.2A)
HEM  A 413 (-3.0A)
 0.98A 4x5iA-2zbzA:
undetectable		 4x5iA-2zbzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 11 LEU A 288
LEU A 369
LEU A 372
ILE A 368
LEU A 284
 None
 1.03A 4zowA-2zbzA:
undetectable		 4zowA-2zbzA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 5 SER A  70
ARG A 107
GLY A 104
THR A 110
 None
HEM  A 413 (-3.9A)
None
None
 1.05A 5btiA-2zbzA:
undetectable
5btiB-2zbzA:
undetectable		 5btiA-2zbzA:
24.11
5btiB-2zbzA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 5 SER A  70
ARG A 107
GLY A 104
THR A 110
 None
HEM  A 413 (-3.9A)
None
None
 1.03A 5btiC-2zbzA:
undetectable
5btiD-2zbzA:
undetectable		 5btiC-2zbzA:
24.11
5btiD-2zbzA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 ASP A 292
ARG A  73
ARG A 297
 None
VDX  A 501 ( 4.2A)
HEM  A 413 (-3.0A)
 0.99A 5eajB-2zbzA:
undetectable		 5eajB-2zbzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 6 LEU A 346
THR A  55
TRP A  52
GLN A 308
 None
 1.49A 5h8tA-2zbzA:
undetectable		 5h8tA-2zbzA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 VAL A 404
LEU A 288
MET A 252
 None
 0.85A 5ikrA-2zbzA:
undetectable		 5ikrA-2zbzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		4 / 7 ALA A 250
THR A 253
ILE A 368
LEU A 365
 None
 0.81A 5te8C-2zbzA:
27.8		 5te8C-2zbzA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 ASN A  72
VAL A 352
HIS A 103
 None
None
HEM  A 413 (-3.9A)
 0.57A 6a5yD-2zbzA:
undetectable		 6a5yD-2zbzA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		3 / 3 LEU A 284
ASP A 292
ILE A 396
 None
 0.62A 6dh0B-2zbzA:
undetectable		 6dh0B-2zbzA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2zbz CYTOCHROME P450-SU1
(Streptomyces
griseolus) 		5 / 10 GLY A 217
ALA A 238
LEU A 163
GLY A 164
LEU A 285
 None
 1.15A 6hqbA-2zbzA:
undetectable
6hqbJ-2zbzA:
undetectable		 6hqbA-2zbzA:
10.68
6hqbJ-2zbzA:
7.04