SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 TYR A 308
LEU A 249
LEU A  54
PRO A  50
TYR A 290
 None
 1.32A 1p33B-2zc0A:
undetectable		 1p33B-2zc0A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 TYR A 308
LEU A 249
LEU A  54
PRO A  50
TYR A 290
 None
 1.30A 1p33C-2zc0A:
undetectable		 1p33C-2zc0A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 109
ALA A 110
ILE A 212
GLY A 115
ILE A 258
 None
 0.89A 1sdtB-2zc0A:
undetectable		 1sdtB-2zc0A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 109
ALA A 110
ILE A 212
GLY A 115
ILE A 258
 None
 0.84A 2avsB-2zc0A:
undetectable		 2avsB-2zc0A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 109
ALA A 110
ILE A 212
GLY A 115
ILE A 258
 None
 0.89A 2avvE-2zc0A:
undetectable		 2avvE-2zc0A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 107
GLY A 109
ALA A 242
THR A 215
ALA A 216
 PMP  A 409 (-3.7A)
None
None
None
PMP  A 409 ( 3.7A)
 1.05A 2gluB-2zc0A:
undetectable		 2gluB-2zc0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 243
ALA A 242
ASP A 214
ILE A 105
VAL A 268
 None
None
PMP  A 409 (-2.7A)
None
None
 0.95A 2ieoA-2zc0A:
undetectable		 2ieoA-2zc0A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		3 / 3 GLY A  42
ASP A  43
SER A 383
 None
 0.55A 2qhfA-2zc0A:
undetectable		 2qhfA-2zc0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 7 TYR A 179
GLY A 109
ALA A 110
LEU A 114
 None
 0.78A 2wekB-2zc0A:
3.6		 2wekB-2zc0A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.44A 2y00A-2zc0A:
undetectable		 2y00A-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 11 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.41A 2y04A-2zc0A:
undetectable		 2y04A-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 THR A 183
ILE A 227
LEU A 291
ASN A 218
PHE A  87
 None
 1.08A 2y7hB-2zc0A:
2.3		 2y7hB-2zc0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 THR A 183
ILE A 227
LEU A 291
ASN A 218
PHE A  87
 None
 1.08A 2y7hC-2zc0A:
2.1		 2y7hC-2zc0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 243
ALA A 242
ASP A 214
ILE A 105
VAL A 268
 None
None
PMP  A 409 (-2.7A)
None
None
 1.00A 2z54A-2zc0A:
undetectable		 2z54A-2zc0A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 11 GLY A 109
ALA A 110
ILE A 212
GLY A 115
ILE A 258
 None
 0.89A 3em4A-2zc0A:
undetectable		 3em4A-2zc0A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 11 GLY A 109
ALA A 110
ILE A 212
GLY A 115
ILE A 258
 None
 0.93A 3em4U-2zc0A:
undetectable		 3em4U-2zc0A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 LEU A 114
GLY A 115
LEU A 118
ILE A 240
PHE A 139
 None
 1.09A 3gwwA-2zc0A:
undetectable		 3gwwA-2zc0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 4 GLY A  76
VAL A 102
GLY A 106
THR A 108
 None
None
PMP  A 409 (-2.8A)
PMP  A 409 (-3.6A)
 0.93A 3ib2A-2zc0A:
undetectable		 3ib2A-2zc0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 109
ALA A 110
ILE A 212
GLY A 115
ILE A 258
 None
 0.90A 3nduD-2zc0A:
undetectable		 3nduD-2zc0A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		6 / 11 GLY A 243
ALA A 242
ASP A 214
ILE A 105
VAL A 268
ILE A 258
 None
None
PMP  A 409 (-2.7A)
None
None
None
 1.49A 3ndxB-2zc0A:
undetectable		 3ndxB-2zc0A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		3 / 3 GLU A  79
LEU A 288
LEU A  62
 None
 0.73A 3ohtA-2zc0A:
undetectable		 3ohtA-2zc0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		3 / 3 GLU A  79
LEU A 288
LEU A  62
 None
 0.71A 3ohtB-2zc0A:
undetectable		 3ohtB-2zc0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 5 ILE A  77
GLN A 284
ILE A 282
TYR A 285
 None
 1.03A 4a99D-2zc0A:
undetectable		 4a99D-2zc0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.34A 4amjA-2zc0A:
undetectable		 4amjA-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 SER A  38
PHE A 336
ASN A 381
ASN A 186
TYR A 132
 None
None
None
PMP  A 409 (-3.7A)
PMP  A 409 (-3.7A)
 1.36A 4amjB-2zc0A:
undetectable		 4amjB-2zc0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 4 LEU A  94
ALA A  85
ILE A 101
LYS A 231
 None
 1.45A 4eixA-2zc0A:
undetectable		 4eixA-2zc0A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		3 / 3 LYS A 171
LEU A 168
ALA A 170
 None
 0.59A 4ikiA-2zc0A:
undetectable		 4ikiA-2zc0A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 TYR A 290
THR A 244
GLY A 250
ALA A 287
HIS A 300
 None
PMP  A 409 (-2.8A)
None
None
None
 1.06A 4rvgA-2zc0A:
4.2		 4rvgA-2zc0A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 THR A 135
LEU A 137
ALA A 138
LEU A 142
GLY A 106
 None
IMD  A 410 (-4.6A)
None
None
PMP  A 409 (-2.8A)
 0.96A 4xi3C-2zc0A:
undetectable		 4xi3C-2zc0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 6 LYS A 330
PRO A 331
LEU A 319
GLU A 320
 None
 0.81A 4z4cA-2zc0A:
2.4		 4z4cA-2zc0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 7 LYS A 330
PRO A 331
LEU A 319
GLU A 320
 None
 0.80A 4z4fA-2zc0A:
2.3		 4z4fA-2zc0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 8 LEU A 291
PHE A 296
PHE A 219
PRO A  50
 None
 0.72A 5m0oC-2zc0A:
undetectable		 5m0oC-2zc0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 VAL A 241
GLU A 213
LEU A 291
PHE A 219
PRO A 229
 None
 1.32A 5nd2B-2zc0A:
undetectable		 5nd2B-2zc0A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		4 / 7 LYS A 330
PRO A 331
LEU A 319
GLU A 320
 None
 0.72A 5t7bA-2zc0A:
2.2		 5t7bA-2zc0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2zc0 ALANINE GLYOXYLATE
TRANSAMINASE
(Thermococcus
litoralis) 		5 / 12 LEU A 113
GLY A 107
GLY A 109
ILE A 255
SER A 246
 None
PMP  A 409 (-3.7A)
None
None
PMP  A 409 (-3.1A)
 1.04A 6ectA-2zc0A:
undetectable		 6ectA-2zc0A:
22.48