SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2zc2 DNAD-LIKE
REPLICATION PROTEIN
(Streptococcus
mutans) 		4 / 7 ASP A 130
ARG A 137
LEU A 139
GLU A 143
 ZN  A 507 (-1.9A)
None
None
None
 0.90A 2cdqB-2zc2A:
undetectable		 2cdqB-2zc2A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2zc2 DNAD-LIKE
REPLICATION PROTEIN
(Streptococcus
mutans) 		4 / 8 ASN A 185
LEU A 160
ALA A 164
SER A 163
 None
 0.96A 3kp6A-2zc2A:
undetectable		 3kp6A-2zc2A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2zc2 DNAD-LIKE
REPLICATION PROTEIN
(Streptococcus
mutans) 		3 / 3 SER A 163
ASP A 153
ASP A 157
 None
 0.76A 4uckA-2zc2A:
undetectable		 4uckA-2zc2A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2zc2 DNAD-LIKE
REPLICATION PROTEIN
(Streptococcus
mutans) 		4 / 7 PHE A 131
LEU A 135
GLU A 143
THR A 150
 None
 1.05A 4wnvD-2zc2A:
undetectable		 4wnvD-2zc2A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2zc2 DNAD-LIKE
REPLICATION PROTEIN
(Streptococcus
mutans) 		4 / 7 LEU A 127
ASP A 157
THR A 156
HIS A 188
 None
 1.19A 5w97C-2zc2A:
undetectable
5w97a-2zc2A:
undetectable
5w97c-2zc2A:
undetectable		 5w97C-2zc2A:
13.60
5w97a-2zc2A:
8.28
5w97c-2zc2A:
13.60