SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		4 / 8 LEU C 714
PRO C 646
VAL C 663
GLY C 664
 None
 0.99A 1hrkA-2zc4C:
undetectable		 1hrkA-2zc4C:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		4 / 8 LEU C 714
PRO C 646
VAL C 663
GLY C 664
 None
 0.97A 1hrkB-2zc4C:
undetectable		 1hrkB-2zc4C:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		3 / 3 GLU C 652
LEU C 649
ASP C 648
 None
 0.43A 3ko0T-2zc4C:
undetectable		 3ko0T-2zc4C:
27.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		3 / 3 PRO C 682
SER C 634
ASN C 656
 None
 0.92A 3lslG-2zc4C:
undetectable		 3lslG-2zc4C:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		4 / 7 ALA C 707
THR C 706
GLN C 728
VAL C 727
 None
 0.93A 6cduA-2zc4C:
undetectable
6cduE-2zc4C:
undetectable		 6cduA-2zc4C:
17.85
6cduE-2zc4C:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		4 / 8 GLN C 728
VAL C 727
ALA C 707
THR C 706
 None
 0.89A 6cduD-2zc4C:
undetectable
6cduE-2zc4C:
undetectable		 6cduD-2zc4C:
17.85
6cduE-2zc4C:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		4 / 7 ALA C 707
THR C 706
GLN C 728
VAL C 727
 None
 0.92A 6cduF-2zc4C:
undetectable
6cduJ-2zc4C:
undetectable		 6cduF-2zc4C:
17.85
6cduJ-2zc4C:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zc4 PENICILLIN-BINDING
PROTEIN 2X
(Streptococcus
pneumoniae) 		4 / 7 GLN C 728
VAL C 727
ALA C 707
THR C 706
 None
 0.88A 6cduH-2zc4C:
undetectable
6cduI-2zc4C:
undetectable		 6cduH-2zc4C:
17.85
6cduI-2zc4C:
17.85