SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zc7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		4 / 4 ILE A  65
MET A 338
VAL A 283
GLY A 317
 None
 1.01A 1e06B-2zc7A:
undetectable		 1e06B-2zc7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		4 / 6 GLN A 120
TYR A 221
VAL A 211
GLY A 214
 None
 1.05A 1ekjC-2zc7A:
undetectable
1ekjD-2zc7A:
undetectable		 1ekjC-2zc7A:
19.78
1ekjD-2zc7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 8 GLY A  81
GLY A 251
LEU A 254
SER A 247
GLY A  74
 None
 1.32A 1jhqA-2zc7A:
undetectable		 1jhqA-2zc7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 9 GLY A  81
GLY A 251
LEU A 254
SER A 247
GLY A  74
 None
 1.30A 1jhyA-2zc7A:
undetectable		 1jhyA-2zc7A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		7 / 10 GLY A  63
LEU A 119
GLN A 120
ASN A 152
TYR A 221
THR A 316
GLY A 317
 None
 1.24A 1kvlA-2zc7A:
61.4		 1kvlA-2zc7A:
71.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 10 GLY A 317
LEU A 119
GLN A 120
TYR A 150
LYS A 315
 None
 1.10A 1kvlA-2zc7A:
61.4		 1kvlA-2zc7A:
71.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		8 / 10 LEU A 119
GLN A 120
TYR A 150
ASN A 152
TYR A 221
LYS A 315
THR A 316
GLY A 317
 None
 0.44A 1kvlA-2zc7A:
61.4		 1kvlA-2zc7A:
71.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 9 GLY A  81
GLY A 251
LEU A 254
SER A 247
GLY A  74
 None
 1.32A 1l4nA-2zc7A:
undetectable		 1l4nA-2zc7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 9 GLY A  81
GLY A 251
LEU A 254
SER A 247
GLY A  74
 None
 1.31A 1l5mA-2zc7A:
undetectable		 1l5mA-2zc7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		4 / 4 ALA A 231
VAL A 337
ALA A  31
HIS A  39
 None
 1.23A 1q23K-2zc7A:
undetectable		 1q23K-2zc7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 12 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.14A 1r30A-2zc7A:
undetectable		 1r30A-2zc7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 12 THR A  58
ASN A 341
ILE A  25
LEU A  19
VAL A  16
 None
 1.15A 1r30B-2zc7A:
undetectable		 1r30B-2zc7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		6 / 12 SER A  64
LYS A  67
ASN A 152
LYS A 315
GLY A 317
SER A 318
 None
 0.63A 1ymxB-2zc7A:
14.8		 1ymxB-2zc7A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 11 GLY A 321
SER A 343
ALA A 220
THR A  70
ILE A  65
 None
 1.14A 2nnhA-2zc7A:
undetectable		 2nnhA-2zc7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
THR A 316
GLY A 317
 None
 0.53A 3huoA-2zc7A:
14.9		 3huoA-2zc7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
GLY A 317
SER A 318
 None
 0.72A 3huoB-2zc7A:
14.7		 3huoB-2zc7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 316
GLY A 317
ARG A 349
 None
 0.80A 3mzeA-2zc7A:
14.3		 3mzeA-2zc7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		6 / 12 SER A  64
LYS A  67
THR A 316
GLY A 317
THR A 319
ARG A 349
 None
 0.97A 3mzeA-2zc7A:
14.3		 3mzeA-2zc7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		4 / 5 LEU A 107
GLN A 267
THR A 111
GLU A 300
 None
 1.34A 3n58C-2zc7A:
undetectable		 3n58C-2zc7A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 10 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.99A 3oxwC-2zc7A:
undetectable		 3oxwC-2zc7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 11 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.92A 3oxxD-2zc7A:
undetectable		 3oxxD-2zc7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_1
(BETA-LACTAMASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
GLY A 317
SER A 318
 None
 0.62A 3q07B-2zc7A:
14.6		 3q07B-2zc7A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 12 ARG A 177
GLY A  75
MET A 106
GLU A  82
ALA A 162
 None
 1.35A 3t7sC-2zc7A:
undetectable		 3t7sC-2zc7A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 9 LEU A  85
ALA A 162
GLY A 156
ILE A 155
LEU A 107
 None
 1.05A 3u7sA-2zc7A:
undetectable		 3u7sA-2zc7A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		5 / 10 ASN A 152
LYS A 315
THR A 316
GLY A 317
ARG A 349
 None
 1.21A 4fh2A-2zc7A:
13.9		 4fh2A-2zc7A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_2
(RIBOFLAVIN LYASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		4 / 4 ASN A 226
GLN A 228
ASP A 229
THR A 175
 None
 1.20A 5w4zB-2zc7A:
0.0		 5w4zB-2zc7A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		4 / 6 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 None
 1.05A 6brdB-2zc7A:
0.0		 6brdB-2zc7A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2zc7 BETA-LACTAMASE ACT-1
(Klebsiella
pneumoniae) 		3 / 3 TYR A 135
ALA A 114
LEU A 109
 None
 0.74A 6d9kF-2zc7A:
undetectable		 6d9kF-2zc7A:
19.64