SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 7 ALA A  85
GLU A  84
LEU A  86
VAL A  75
 None
 0.91A 1hk2A-2zc8A:
undetectable		 1hk2A-2zc8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 ARG A  35
LEU A  33
PRO A 342
VAL A 328
 None
 0.96A 1hrkB-2zc8A:
3.0		 1hrkB-2zc8A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 11 ALA A 264
GLY A 267
GLU A 271
TYR A  55
GLU A 293
 None
 1.40A 1n6cA-2zc8A:
undetectable		 1n6cA-2zc8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		3 / 3 ARG A 203
TYR A 170
LYS A 174
 None
 1.00A 1uujB-2zc8A:
undetectable		 1uujB-2zc8A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 12 GLY A 270
LEU A  86
VAL A 275
LEU A 273
GLY A 243
 None
 1.03A 2f8lA-2zc8A:
undetectable		 2f8lA-2zc8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 VAL A 102
ARG A  64
ILE A  10
GLY A  47
 None
 0.92A 2gssA-2zc8A:
undetectable		 2gssA-2zc8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 VAL A 102
ARG A  64
ILE A  10
GLY A  47
 None
 0.92A 2gssB-2zc8A:
undetectable		 2gssB-2zc8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 7 THR A 145
ALA A 189
TYR A 193
LEU A 204
 None
 0.98A 2hzqA-2zc8A:
undetectable		 2hzqA-2zc8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 LEU A  86
LEU A  80
ALA A 106
ALA A   6
 None
 0.76A 2vcvP-2zc8A:
undetectable		 2vcvP-2zc8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 9 ILE A  31
LEU A 332
ARG A 298
GLY A 297
ALA A 299
 None
 1.38A 2xh9B-2zc8A:
undetectable		 2xh9B-2zc8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 7 ARG A 298
PRO A 263
SER A 272
GLY A 290
 None
 1.05A 3hcnA-2zc8A:
3.1		 3hcnA-2zc8A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 ARG A 298
PRO A 263
SER A 272
GLY A 290
 None
 1.04A 3hcrA-2zc8A:
3.0		 3hcrA-2zc8A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 VAL A 102
ARG A  64
ILE A  10
GLY A  47
 None
 0.90A 3n9jA-2zc8A:
undetectable		 3n9jA-2zc8A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		3 / 3 ARG A  64
LEU A   8
THR A 360
 None
 0.87A 3oxcA-2zc8A:
undetectable		 3oxcA-2zc8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 11 ARG A  35
LEU A 351
ALA A 294
VAL A 356
ILE A 327
 None
 1.27A 3oxxB-2zc8A:
undetectable		 3oxxB-2zc8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 ARG A 117
PRO A  83
MET A   1
TRP A 111
 None
 1.29A 4f4dB-2zc8A:
2.0		 4f4dB-2zc8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 12 ALA A 264
GLY A 267
GLU A 271
TYR A  55
GLU A 293
 None
 1.20A 4jlgA-2zc8A:
undetectable		 4jlgA-2zc8A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 12 VAL A 176
ARG A 177
ILE A 164
LEU A 162
LEU A 207
 None
 1.05A 4m11B-2zc8A:
undetectable		 4m11B-2zc8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 9 ALA A 106
ILE A 327
VAL A 328
GLY A 297
VAL A 349
 None
 1.07A 4r20B-2zc8A:
undetectable		 4r20B-2zc8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 8 LEU A 266
GLY A 267
GLU A  84
ALA A  91
 None
 0.88A 4rjdA-2zc8A:
undetectable
4rjdB-2zc8A:
undetectable		 4rjdA-2zc8A:
12.05
4rjdB-2zc8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 12 LEU A  86
LEU A 103
ARG A  78
LEU A  76
MET A 366
 None
 1.08A 4x1fA-2zc8A:
undetectable		 4x1fA-2zc8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 12 LEU A  86
LEU A 103
ARG A  78
LEU A  76
MET A 366
 None
 1.05A 4x1gA-2zc8A:
undetectable		 4x1gA-2zc8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 4 LEU A 278
LEU A 241
GLY A 243
GLU A 271
 None
 1.12A 5hhjA-2zc8A:
undetectable		 5hhjA-2zc8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		4 / 7 ASP A 109
TRP A 111
ALA A 112
LEU A 115
 None
 1.06A 5nwvA-2zc8A:
undetectable		 5nwvA-2zc8A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		5 / 12 GLY A 337
PRO A 340
ALA A 129
GLU A 155
VAL A 134
 None
 1.23A 5x6yA-2zc8A:
undetectable		 5x6yA-2zc8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2zc8 N-ACYLAMINO ACID
RACEMASE
(Thermus
thermophilus) 		3 / 3 LYS A 113
VAL A 345
ASP A 109
 None
 0.70A 6fgdA-2zc8A:
3.2		 6fgdA-2zc8A:
24.03