SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 7 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.97A 1dvxB-2zchH:
undetectable		 1dvxB-2zchH:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 6 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.76A 1ictB-2zchH:
undetectable		 1ictB-2zchH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.44A 2y03A-2zchH:
undetectable		 2y03A-2zchH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.48A 2y03B-2zchH:
undetectable		 2y03B-2zchH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 7 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.90A 3cfqA-2zchH:
3.8
3cfqB-2zchH:
3.6		 3cfqA-2zchH:
21.10
3cfqB-2zchH:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 7 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.91A 3d2tA-2zchH:
undetectable		 3d2tA-2zchH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 6 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.85A 3d2tB-2zchH:
3.9		 3d2tB-2zchH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.42A 3nyaA-2zchH:
undetectable		 3nyaA-2zchH:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 7 LYS H 205
ALA H 198
SER H 149
THR H 151
 None
 0.85A 4d7bA-2zchH:
undetectable		 4d7bA-2zchH:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		3 / 3 ASP H  10
TRP H  36
SER H   7
 None
 1.00A 4lrhB-2zchH:
undetectable		 4lrhB-2zchH:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.30A 4m7kH-2zchH:
26.7		 4m7kH-2zchH:
64.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2zch MONOCLONAL ANTIBODY
8G8F5 FAB
(Mus
musculus) 		4 / 6 ASN H  76
ALA H  24
PRO H  52
TYR H  27
 None
 1.03A 5umd2-2zchH:
undetectable
5umdF-2zchH:
undetectable		 5umd2-2zchH:
16.51
5umdF-2zchH:
13.97