SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 8 ILE A 412
LEU A 308
MET A 247
ALA A 299
MET A 251
 None
 1.09A 1a29A-2zciA:
undetectable		 1a29A-2zciA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 11 ALA A 291
LEU A 301
LEU A 252
GLY A 295
ALA A 269
 None
 1.04A 1b02A-2zciA:
undetectable		 1b02A-2zciA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 ASP A 140
TRP A 246
GLY A 245
GLU A 244
GLU A 243
 None
 1.18A 1gahA-2zciA:
undetectable		 1gahA-2zciA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 8 LEU A 279
VAL A 499
GLY A 418
LEU A 522
 None
 0.95A 1jlbA-2zciA:
undetectable		 1jlbA-2zciA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		3 / 3 TRP A 246
LEU A 303
LYS A 488
 None
 0.94A 1yajK-2zciA:
undetectable		 1yajK-2zciA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		3 / 3 ALA A 332
THR A 324
PHE A 317
 None
 0.61A 2c6nB-2zciA:
undetectable		 2c6nB-2zciA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 8 LYS A 229
LYS A 230
HIS A 250
ASP A 297
ARG A 389
 None
 0.53A 2rk8A-2zciA:
49.5		 2rk8A-2zciA:
48.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 7 LYS A 229
LYS A 230
HIS A 250
ASP A 297
ARG A 389
 None
 0.37A 2rk8B-2zciA:
50.6		 2rk8B-2zciA:
48.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 THR A 285
GLY A 514
GLY A 516
LEU A 279
PHE A 510
 None
 1.19A 2yvlD-2zciA:
undetectable		 2yvlD-2zciA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 7 ASP A  79
SER A 219
SER A 183
TRP A 197
 None
 1.30A 3bc9A-2zciA:
undetectable		 3bc9A-2zciA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		3 / 3 SER A 216
GLY A 218
GLY A 220
 None
 0.49A 3bogA-2zciA:
undetectable
3bogC-2zciA:
undetectable		 3bogA-2zciA:
undetectable
3bogC-2zciA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 8 GLU A 357
SER A 379
LEU A 367
ALA A 384
 None
 0.91A 3ns1L-2zciA:
undetectable		 3ns1L-2zciA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 10 ALA A 445
LEU A 498
ALA A 567
THR A 538
THR A 431
 None
 1.46A 3r9cA-2zciA:
undetectable		 3r9cA-2zciA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 LEU A 252
ALA A 269
LEU A 416
ALA A 414
ILE A 412
 None
 0.96A 3ut5B-2zciA:
undetectable		 3ut5B-2zciA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 7 VAL A 533
VAL A 428
PHE A 497
ILE A 529
 None
 0.94A 3zjqA-2zciA:
undetectable		 3zjqA-2zciA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 7 VAL A 533
VAL A 428
PHE A 497
ILE A 529
 None
 0.93A 3zjqB-2zciA:
undetectable		 3zjqB-2zciA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 LEU A 252
ALA A 269
LEU A 416
ALA A 414
ILE A 412
 None
 1.07A 4o2bB-2zciA:
2.2		 4o2bB-2zciA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 7 LEU A 308
MET A 493
MET A 247
ALA A 299
MET A 251
 None
 1.39A 4rjdB-2zciA:
undetectable		 4rjdB-2zciA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 6 LEU A 444
ALA A 269
MET A 251
MET A 467
 None
 0.79A 4wboC-2zciA:
undetectable		 4wboC-2zciA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 ASP A 297
ASP A 296
PHE A 470
ILE A 298
ALA A 233
 None
 1.25A 4wh5A-2zciA:
undetectable		 4wh5A-2zciA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 11 ILE A  60
LEU A 367
ASP A 353
LEU A  62
GLY A 352
 None
 1.37A 5fctA-2zciA:
undetectable		 5fctA-2zciA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 8 ASN A 101
GLU A 249
HIS A 250
THR A 206
 None
 1.37A 5hqaA-2zciA:
undetectable		 5hqaA-2zciA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 LEU A 252
ALA A 269
LEU A 416
ALA A 414
ILE A 412
 None
 1.06A 5mioB-2zciA:
undetectable		 5mioB-2zciA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 PHE A  38
GLY A 175
GLY A 164
PHE A 177
VAL A 145
 None
 0.82A 5w4zA-2zciA:
undetectable		 5w4zA-2zciA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 PHE A  38
GLY A 175
GLY A 164
PHE A 177
VAL A 145
 None
 0.89A 5w4zB-2zciA:
undetectable		 5w4zB-2zciA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 6 ALA A 400
GLN A 292
LYS A 255
ASP A 406
 None
 1.39A 5y9aA-2zciA:
undetectable		 5y9aA-2zciA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		4 / 6 SER A 120
TYR A 217
GLN A  32
THR A 202
 None
 1.38A 6djzA-2zciA:
undetectable		 6djzA-2zciA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 12 GLY A 223
ILE A 226
ILE A 236
VAL A 178
ILE A 214
 None
 0.94A 6emuA-2zciA:
undetectable		 6emuA-2zciA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 10 ILE A  60
LEU A 367
ASP A 353
LEU A  62
GLY A 352
 None
 1.33A 6r2eB-2zciA:
undetectable		 6r2eB-2zciA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 10 ILE A  60
LEU A 367
ASP A 353
LEU A  62
GLY A 352
 None
 1.28A 6r2eC-2zciA:
undetectable		 6r2eC-2zciA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 10 ILE A  60
LEU A 367
ASP A 353
LEU A  62
GLY A 352
 None
 1.36A 6r2eD-2zciA:
undetectable		 6r2eD-2zciA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 11 ILE A  60
LEU A 367
ASP A 353
LEU A  62
GLY A 352
 None
 1.33A 6r2eF-2zciA:
undetectable		 6r2eF-2zciA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Corynebacterium
glutamicum) 		5 / 11 ILE A  60
LEU A 367
ASP A 353
LEU A  62
GLY A 352
 None
 1.35A 6r2eG-2zciA:
undetectable		 6r2eG-2zciA:
19.66